Application of the microRNA‐302/367 cluster in cancer therapy

Liu, Jiajia; Wang, Ying; Ji, Ping; Jin, Xin

doi:10.1111/cas.14317

Cited by 22 publications

(17 citation statements)

References 78 publications

(133 reference statements)

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“…We found both miR-302 and miR-367 as prognostic markers from the shared ceRNA network. The miR-302/367 cluster has been previously identified in PRAD-, BRCA-, COAD-, READ-, and UCEC-associated pathways, supporting our findings [41].…”

Section: Discussionsupporting

confidence: 91%

Identifying Complex lncRNA/Pseudogene–miRNA–mRNA Crosstalk in Hormone-Dependent Cancers

Jayarathna

Rentería

Sauret

et al. 2021

Biology

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The discovery of microRNAs (miRNAs) has fundamentally transformed our understanding of gene regulation. The competing endogenous RNA (ceRNA) hypothesis postulates that messenger RNAs and other RNA transcripts, such as long non-coding RNAs and pseudogenes, can act as natural miRNA sponges. These RNAs influence each other’s expression levels by competing for the same pool of miRNAs through miRNA response elements on their target transcripts, thereby modulating gene expression and protein activity. In recent years, these ceRNA regulatory networks have gained considerable attention in cancer research. Several studies have identified cancer-specific ceRNA networks. Nevertheless, prior bioinformatic analyses have focused on long-non-coding RNA-associated ceRNA networks. Here, we identify an extended ceRNA network (including both long non-coding RNAs and pseudogenes) shared across a group of five hormone-dependent (HD) cancers, i.e., prostate, breast, colon, rectal, and endometrial cancers, using data from The Cancer Genome Atlas (TCGA). We performed a functional enrichment analysis for differentially expressed genes in the shared ceRNA network of HD cancers, followed by a survival analysis to determine their prognostic ability. We identified two long non-coding RNAs, nine genes, and seventy-four miRNAs in the shared ceRNA network across five HD cancers. Among them, two genes and forty-one miRNAs were associated with at least one HD cancer survival. This study is the first to investigate pseudogene-associated ceRNAs across a group of related cancers and highlights the value of this approach to understanding the shared molecular pathogenesis in a group of related diseases.

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Section: Discussionsupporting

confidence: 91%

Identifying Complex lncRNA/Pseudogene–miRNA–mRNA Crosstalk in Hormone-Dependent Cancers

Jayarathna

Rentería

Sauret

et al. 2021

Biology

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show abstract

“…We found both miR-302 and miR-367 as prognostic markers from the shared ceRNA network. The miR-302/367 cluster has been previously identified in PRAD, BRCA, COLCA, and UCEC associated pathways supporting our findings [41].…”

Section: Discussionsupporting

confidence: 91%

Identifying Complex lncRNA/Pseudogene-miRNA-mRNA Crosstalk in Hormone-Dependent Cancers

Jayarathna¹,

Rentería²,

Sauret³

et al. 2021

Preprint

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The discovery of microRNAs (miRNAs) has fundamentally transformed our understanding of gene regulation. The competing endogenous RNA (ceRNA) hypothesis postulates that not only messenger RNAs but also other RNA transcripts, such as long non-coding RNAs and pseudogenes, can act as natural miRNA sponges. These RNAs influence each other’s expression levels by competing for the same pool of miRNAs through miRNA response elements on their target transcripts, thereby modulating gene expression and protein activity. In recent years, these ceRNA regulatory networks have gained considerable attention in cancer research. Several studies have identified cancer-specific ceRNA networks. Nevertheless, prior bioinformatic analyses have focused on long non-coding RNAs-associated ceRNA networks. Here, we identify an extended-ceRNA network (including both long non-coding RNAs and pseudogenes) shared across a group of four hormone-dependent (HD) cancers, i.e., prostate, breast, colorectal, and endometrial cancers, using data from The Cancer Genome Atlas (TCGA). We performed a functional enrichment analysis for differentially expressed genes in the shared ceRNA network of HD cancers, followed by a survival analysis to determine their prognostic ability. We identified two long non-coding RNAs, nine genes, and seventy-four miRNAs in the shared ceRNA network across four HD cancers. Among them, two genes and forty-one miRNAs were associated with at least one HD cancer survival. This study is the first to investigate pseudogene associated ceRNAs across a group of related cancers and highlights the value of this approach to understanding shared molecular pathogenesis in a group of related diseases.

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“…So, miRs are recognized as reliable biomarkers of prognosis and treatment of tumors. [ 12 ] Strongly expressed miR-367 was conducive to the elevation of the sensitivity to therapeutic drug in ovarian cancer. [ 17 ] In this study, we were inspired to explore the possible association of miR-367 in biological processes of BC, and found that previous studies have indicated that several miRNAs such as miR-15a, miR-21, miR-205, miR-342-3p, and miR-520a-5p were associated with a few molecular and clinicopathologic features and poor prognosis in BC patients.…”

Section: Discussionmentioning

confidence: 99%

“…[ 11 ] As a key member of the miR-302/367 cluster, miR-367 can play a role in a number of cancers as it prevents cell senescence and death, maintains proliferation signal activation, sabotages growth inhibitors, and modulates cellular biological activities as well as angiogenesis. [ 12 ] Kaid and her colleagues discovered that miR-367 may be a medical target, which can be used as a marker in aggressive embryonal central nervous system tumor and facilitates prognosis and early diagnosis. [ 13 ] Furthermore, miR-367-3p expression levels are closely correlated with International Federation of Gynecology and Obstetrics (FIGO) stage and lymph node metastasis, and high expression of miR-367-3p allows to a high survival rate, oppresses cancer cell metastasis, and quenches the malignant behaviors of tumor in endometrial cancer.…”

Section: Introductionmentioning

confidence: 99%

Correlation of microRNA-367 in the clinicopathologic features and prognosis of breast cancer patients

Liu¹,

Pan²,

Fu³

2021

Medicine

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Breast cancer (BC) is a malignant tumor originating from cells of the breast. Notably, microRNAs have been recognized as biomarkers of BC metastasis. The present study is designed to evaluate the association between microRNA (miR)-367 expression and BC with the variance of clinicopathologic features and prognosis. Initially, 63 BC patients were allocated in the BC group, while the other 40 healthy volunteers were recruited as the control group. miR-367 expression in the serum of patients and healthy controls was detected using real-time polymerase chain reaction. Furthermore, the relation between miR-367 in serum and clinicopathologic features and prognosis of BC patients was accessed. miR-367 expression in serum of the BC group was evidently lower than that in the control group (all P < .001). Besides, miR-367 underexpression in the BC group was closely associated with the variance in tumor nodes metastasis advanced stage, tumor diameter, and lymph node metastasis of BC (all P < .001). In addition, compared with the control group, poorly expressed miR-367 BC group had short period of disease-free survival and overall survival (all P < .001). Our study demonstrated that miR-367 expression is associated with BC clinicopathologic features and prognosis. This investigation may offer new insight for BC treatment.

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Application of the microRNA‐302/367 cluster in cancer therapy

Cited by 22 publications

References 78 publications

Identifying Complex lncRNA/Pseudogene–miRNA–mRNA Crosstalk in Hormone-Dependent Cancers

Identifying Complex lncRNA/Pseudogene–miRNA–mRNA Crosstalk in Hormone-Dependent Cancers

Identifying Complex lncRNA/Pseudogene-miRNA-mRNA Crosstalk in Hormone-Dependent Cancers

Correlation of microRNA-367 in the clinicopathologic features and prognosis of breast cancer patients

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