Application of the Oral Minimal Model to Korean Subjects with Normal Glucose Tolerance and Type 2 Diabetes Mellitus

Abstract

BackgroundThe oral minimal model is a simple, useful tool for the assessment of β-cell function and insulin sensitivity across the spectrum of glucose tolerance, including normal glucose tolerance (NGT), prediabetes, and type 2 diabetes mellitus (T2DM) in humans.MethodsPlasma glucose, insulin, and C-peptide levels were measured during a 180-minute, 75-g oral glucose tolerance test in 24 Korean subjects with NGT (n=10) and T2DM (n=14). The parameters in the computational model were estimated, and the indexes for insulin sensitivity and β-cell function were compared between the NGT and T2DM groups.ResultsThe insulin sensitivity index was lower in the T2DM group than the NGT group. The basal index of β-cell responsivity, basal hepatic insulin extraction ratio, and post-glucose challenge hepatic insulin extraction ratio were not different between the NGT and T2DM groups. The dynamic, static, and total β-cell responsivity indexes were significantly lower in the T2DM group than the NGT group. The dynamic, static, and total disposition indexes were also significantly lower in the T2DM group than the NGT group.ConclusionThe oral minimal model can be reproducibly applied to evaluate β-cell function and insulin sensitivity in Koreans.

The Cut-off Values of Triglycerides and Glucose Index for Metabolic Syndrome in American and Korean Adolescents

“…Insulin resistance can be measured directly using the pancreatic suppression test, the hyperinsulinemic-euglycemic clamp technique, or the minimal model approximation of the metabolism of glucose ( 1 2 3 4 ). These tests are invasive, complicated, and cost-intensive procedures; therefore, simpler, indirect methods have been proposed for use in epidemiological and clinical studies.…”

Fimasartan increases glucose‐stimulated insulin secretion in patients with type 2 diabetes and hypertension compared with amlodipine

“…25 In addition, some mathematical models were used to evaluate β-cell function from plasma glucose and C-peptide levels during the OGTT. The oral minimal model, 26 which has been reported to be useful in Korean people, 27 was applied using MATLAB software (Mathworks, Inc., Natick, MA, USA). Another model, developed by Mari et al 28,29 includes dose response (slope = glucose sensitivity), early response (rate sensitivity), and potentiation (time-related secretion increase).…”

Neck Circumference Is Better Associated Than Waist Circumference at Insulin Resistance in Bantu Population from Brazzaville in Republic of Congo

“…Insulin resistance (IR) is considered as a major cardiometabolic risk factor. IR can be evaluated directly by invasive methods, including the hyperinsulinemiceuglycemic clamp technique [1][2][3][4]. These techniques are not accessible in current medical practice due to their invasiveness and their high cost for the vast majority of patients.…”