The Cut-off Values of Triglycerides and Glucose Index for Metabolic Syndrome in American and Korean Adolescents

Moon, Shinje; Park, Joon Sung; Ahn, Yonghan

doi:10.3346/jkms.2017.32.3.427

Cited by 90 publications

(82 citation statements)

References 39 publications

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“…Limited data are reported in pediatric age, in which the TyG index has been described as a useful predictor of metabolic abnormalities in Asian, Mexican American, Non-Hispanic White adolescents (15)(16)(17)(18)(19)(20)(21). Untill now there is no consensus for reference criteria in Caucasian children, besides no pediatric study has been conducted on this topic.…”

Section: U N C O R R E C T E D P R O O Fmentioning

confidence: 99%

Triglyceride Glucose Index as a Surrogate Measure of Insulin Sensitivity in a Caucasian Pediatric Population

Calcaterra¹,

Montalbano²,

Silvestri³

et al. 2024

Jcrpe

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The triglyceride and glucose (TyG) index has been proposed as a simple surrogate of insulin resistance (IR) with high sensitivity as an IR index besides the well known homeostasis model assessment of IR (HOMA-IR). Limited data are reported in children. We investigated the sensitivity and specificity of TyG index in a pediatric Caucasian population, as a surrogate measure of IR and compared the results with HOMA-IR. Methods: We enrolled 541 children (11.7±2.71 yrs). According to body mass index (BMI) chart, the subjects were divided into three groups: normal weight BMI<75th percentile, overweight BMI 75th-95th percentile, and obese>95 th percentile. TyG index was calculated as (ln[fasting triglycerides(mg/dl)×fasting plasma glucose(mg/dl)/2]) and considered pathological when exceeding 7.88. HOMA-IR was calculated as (insulin×glucose)/22.5 and defined pathological whenever exceeding 97.5th percentile for age and sex. Results: In children with overweight/obesity TyG index was higher compared to normal weight subjects (p<0.001). TyG index was correlated with BMI (p<0.001); WHtR (p<0.001), total and HDL cholesterol (p<0.001); ALT (p<0.001), blood pressure (p<0.001). A correlation between TyG index and HOMAIR (p<0.001) as well as high TyG index and pathological HOMA-IR (p<0.001) were noted. The optimal cutoff for IR was considered 7.98 (sensitivity 60%; specificity 78%; AUC 0.69). Conclusions: TyG index is a useful and cost-effective index of IR among children and adolescents. The cutoff 7.98 may be used for IR risk screening in childhood obesity, but we recommend caution when used in other populations.

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Section: U N C O R R E C T E D P R O O Fmentioning

confidence: 99%

Triglyceride Glucose Index as a Surrogate Measure of Insulin Sensitivity in a Caucasian Pediatric Population

Calcaterra¹,

Montalbano²,

Silvestri³

et al. 2024

Jcrpe

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“…indicated that TyG index performed better than HOMA to estimate insulin resistance with hyperglycemic clamp in Brazilian subjects 14 . Additionally, the TyG had been demonstrated to be strongly associated with diabetes, obesity, NAFLD and even metabolic syndrome, all of which were risk factors of hypogonadism 15 – 18 . To the best of our knowledge, no study has investigated the application of TyG in male hypogonadism.…”

Section: Introductionmentioning

confidence: 99%

The Triglycerides and Glucose Index rather than HOMA-IR is more associated with Hypogonadism in Chinese men

Zhang

Chen

Liu

et al. 2017

Sci Rep

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Previous studies have reported that insulin resistant and low testosterone are related. The triglyceride and glucose index (TyG) well mirrors insulin sensitivity. No study investigated the application of TyG in male hypogonadism. We aimed to explore whether TyG was associated with hypogonadism, and also evaluate the ability of TyG compared to HOMA-IR as a possible hypogonadism predictor. A total of 4299 male subjects were enrolled from 22 sites in East China. Hypogonadism was defined as total testosterone <11.3 nmol/L. 695 (16.2%) hypogonadal men had significantly higher TyG index. The prevalence of hypogonadism stepwise increased across increasing TyG quartiles (P < 0.01). TyG was negatively associated with sex hormones and hypogonadism after adjustment for age, current smoking status, hypertension and overweight/obesity (all P for trend <0.01). The full-adjusted odds ratio was 6.1 for the highest quartile compared with the lowest quartile of TyG (95% CI 4.51, 8.25, P < 0.001). On ROC curve analysis, a larger area under the curve was found for TyG (0.71, 95% CI 0.69,0.73) than for HOMA-IR (0.68, 95% CI 0.66,0.70). Thus, the TyG was significantly associated with a higher prevalence of hypogonadism in Chinese men. TyG had a better predictive power for hypogonadism than HOMA-IR.

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“…100 . and adolescents that do not consider pubertal status (42,43) . The lack of a consensus for cut-off points to diagnose dyslipidaemia, hypertension, hyperglycaemia and overweight status results in the adoption of country-specific references for clinical studies.…”

mentioning

confidence: 99%

Dietary patterns and cardiometabolic risk factors among adolescents: systematic review and meta-analysis

et al. 2018

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This study systematised and synthesised the results of observational studies that were aimed at supporting the association between dietary patterns and cardiometabolic risk (CMR) factors among adolescents. Relevant scientific articles were searched in PUBMED, EMBASE, SCIENCE DIRECT, LILACS, WEB OF SCIENCE and SCOPUS. Observational studies that included the measurement of any CMR factor in healthy adolescents and dietary patterns were included. The search strategy retained nineteen articles for qualitative analysis. Among retained articles, the effects of dietary pattern on the means of BMI (n 18), waist circumference (WC) (n 9), systolic blood pressure (n 7), diastolic blood pressure (n 6), blood glucose (n 5) and lipid profile (n 5) were examined. Systematised evidence showed that an unhealthy dietary pattern appears to be associated with poor mean values of CMR factors among adolescents. However, evidence of a protective effect of healthier dietary patterns in this group remains unclear. Considering the number of studies with available information, a meta-analysis of anthropometric measures showed that dietary patterns characterised by the highest intake of unhealthy foods resulted in a higher mean BMI (0·57 kg/m²; 95 % CI 0·51, 0·63) and WC (0·57 cm; 95 % CI 0·47, 0·67) compared with low intake of unhealthy foods. Controversially, patterns characterised by a low intake of healthy foods were associated with a lower mean BMI (-0·41 kg/m²; 95 % CI -0·46,-0·36) and WC (-0·43 cm; 95 % CI -0·52,-0·33). An unhealthy dietary pattern may influence markers of CMR among adolescents, but considering the small number and limitations of the studies included, further studies are warranted to strengthen the evidence of this relation.

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The Cut-off Values of Triglycerides and Glucose Index for Metabolic Syndrome in American and Korean Adolescents

Cited by 90 publications

References 39 publications

Triglyceride Glucose Index as a Surrogate Measure of Insulin Sensitivity in a Caucasian Pediatric Population

Triglyceride Glucose Index as a Surrogate Measure of Insulin Sensitivity in a Caucasian Pediatric Population

The Triglycerides and Glucose Index rather than HOMA-IR is more associated with Hypogonadism in Chinese men

Dietary patterns and cardiometabolic risk factors among adolescents: systematic review and meta-analysis

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