Application of the quinolone antibiotic ciprofloxacin to dacron utilizing textile dyeing technology

Phaneuf, Matthew D.; Ozaki, C. Keith; Bide, Martin; Quist, William C.; Alessi, Jean M.; Tannenbaum, Gary A.; LoGerfo, Frank W.

doi:10.1002/jbm.820270213

Cited by 22 publications

(26 citation statements)

References 21 publications

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“…23,[42][43][44] No other previous studies involved such a direct material/antibiotic interaction. Dye-fiber interactions provided the model for this means of generating infection resistance without exogenous binders.…”

Section: Discussionmentioning

confidence: 99%

“…37 This sustained release is comparable to that observed with the pad-heating processes on unmodified Dacron. 42 The reduced heat involved in this pad/autoclave technique also preserves the functional groups on the material surface, thereby permitting subsequent protein binding using crosslinkers. This study demonstrated that dyeing of Cipro into C-EDA segments followed by autoclaving results in a surface with significant antimicrobial activity and no loss of functional groups.…”

Section: Discussionmentioning

confidence: 99%

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Development of an infection‐resistant, bioactive wound dressing surface

Phaneuf

Bide

Hannel

et al. 2005

J Biomedical Materials Res

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Trauma, whether caused by an accident or in an intentional manner, results in significant morbidity and mortality. The goal of this study was to develop a novel biomaterial surface in vitro and ex vivo that provides both localized infection resistance nd hemostatic properties. Our hypothesis is that a combination of specific surface characteristics can be successfully incorporated into a single biomaterial. Functional groups were created with woven Dacron (Cntrl) material via exposure to ethylenediamine (C-EDA). The antibiotic ciprofloxacin (Cipro) was then applied to the C-EDA material using pad/autoclave technique (C-EDA-AB) followed by surface immobilization of the coagulation cascade enzyme thrombin (C-EDA-AB-Thrombin). Antimicrobial activity by the C-EDA-AB surface persisted for 5 days compared with Cntrl and dipped controls, which lasted <1 h. C-EDA-AB-Thrombin surfaces had 2.6- and 105-fold greater surface thrombin activity compared with nonspecifically bound thrombin and Cipro-dyed surfaces, respectively. Surface thrombus formation ex vivo was evident after 1 min of exposure, with thrombus organization evident by 2.5 min. In contrast, C-EDA-AB and Cntrl segments showed only blood protein adsorption on the fibers. Thus, this study demonstrated that Cipro and thrombin can be simultaneously incorporated onto a biomaterial surface while maintaining their respective biological activities.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Development of an infection‐resistant, bioactive wound dressing surface

Phaneuf

Bide

Hannel

et al. 2005

J Biomedical Materials Res

Self Cite

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“…Ciprofloxacin (Cipro), a quinolone antibiotic, can be directly incorporated into the polymer-using textile by dyeing technology, resulting in a sustained release of antibiotic over a period of time [26,27].…”

Section: Incorporation Of Antibioticsmentioning

confidence: 99%

Recent Developments in Finishing of Synthetic Fibers for Medical Applications

El-Ola

2008

Designed Monomers and Polymers

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Demand for antimicrobial fabrics has grown significantly in recent years because of public awareness of the potential threat of spreading diseases and there will be an increasing role for medical textiles in the future world market. The number of applications of polymeric materials for medical purposes is growing very fast. Polymers have found applications in such diverse biomedical fields as tissue engineering, implantation of medical devices and artificial organs, prostheses, ophthalmology, dentistry, bone repair and many other medical fields. Polymer-based delivery systems enable controlled release of drugs into the body. The aim of the present review is to clarify the antimicrobial agents and their mechanism of action, test methods, and the recent developments in antimicrobial functional finishing of synthetic fibers for medical applications (commercially available bioactive fibers).

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“…Presently, polyester (Dacron, InterVascular Inc., Montvale, NJ) is frequently used to construct the sewing ring. We have previously described a methodology for coating polyester with ciprofloxacin by exploiting its dye-like characteristics [5,6]. Ciprofloxacin exhibits broad-spectrum antimicrobial activity and would be an ideal agent for the prevention of prosthetic valve endocarditis given the microbiology of its causative organisms [7].…”

Section: Introductionmentioning

confidence: 99%