Application of the ratio spectra derivative spectrophotometry to the analysis of cephradine and clavulanic acid in binary mixtures

Electrochemical determination of Cephalothin antibiotic by adsorptive stripping voltammetric technique

“…Such remarkable enhancement for the sensitivity, clearly demonstrates the superiority of this electroanalysis approach over conventional spectrophotometric method which only succeeded to achieve 0.29 g ml −1 [27] or 1.0 g ml −1 [13] concentration levels.…”

“…It is a ␤-lactam antibiotic which is active against a wide variety of bacterial infections [11,12]. Its structure is shown in Scheme 1 and it has been analysed in pharmaceutical formulations and biological samples by various analytical methods such as spectrophotometry [13,14], chemiluminescence [15], fluorescence [16], chromatography [17,18], and various electroanalytical techniques such as potentiometry [19] polarography [20], coulometry and cyclic voltammetry [21] and square-wave voltammetry [22].…”

Simultaneous Determination of Cyproterone Acetate and Ethinylestradiol in Tablets by Derivative Spectrophotometry

“…Derivative spectrophotometry, based on a mathematical transformation of the zero-order curve into the derivative spectra can overcome this problem. 5,6) In this investigation the spectrophotometric parameters were optimized through derivative spectra of cyproterone acetate and ethinylestradiol at different orders and Dl values. The third-order derivative spectra traced with Dlϭ1.4 nm (nϭ2) was used to resolve the spectral overlapping.…”

“…Application of derivative technique of spectrophotometry offers a powerful tool for quantitative analysis of multi-component mixtures. [5][6][7][8][9] In the last decades, this technique has rapidly gained application in the field of pharmaceutical analysis to overcome the problem of interference, due to substances other than analytes, commonly present in pharmaceutical formulations or for combination of two or more drug substances. [10][11][12][13][14][15][16][17] Lack of any published method for simultaneous spectrophotometric determination of cyproterone acetate and ethinylestradiol, therefore, provoked us to investigate the application of derivative spectrophotometry for simultaneous determination of these compounds in pharmaceutical dosage forms using zero-crossing method.…”

Spectrophotometric Methods as Solutions to Pharmaceutical Analysis of β-Lactam Antibiotics

“… a separation and determination of carbapenem and degradant (e.g., the determination of ertapenem and its degradant) when the substraction technique was used [24-25]  a separation and determination of penam and cephem analogs (e.g., the determination of penicillin-G, penicillin-G procain in the presence of dihydrostreptomycin sulphate salts or the determination of cefotaxime and cefadroxil), cephem analog and inhibitor of -lactamases (e.g., the determination of cephradine and clavulanic acid) and carbapenem analog and degradation products (e.g., the determination of meropenem and its degradant) when ratio spectra of derivative with all orders were used [26][27][28][29]  a separation and determination of carbapenem and degradation products (e.g., the determination of ertapenem) when the substraction technique was used [30]  a separation and determination of carbapenem and degradation products (e.g., the determination of ertapenem) when the Kraise's method was used [31]  a separation and determination of penam analogs (e.g., the determination of ampicillin and flucloxacillin) when multivariate methods (classical least squares and principle component regression) were used.…”