Application of totarol as natural antibacterial coating on dental implants for prevention of peri-implantitis

Xu, Zeqian; Krajewski, Stefanie; Weindl, Tobias; Loeffler, Ronny; Li, Ping; Han, Xingting; Geis-Gerstorfer, J; Wendel, Hans-Peter; Scheideler, Lutz; Rupp, Frank

doi:10.1016/j.msec.2020.110701

Cited by 26 publications

(18 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Due to a transoral surgical approach, postoperative oral infections usually involve multiple species of bacteria, including streptococci, anaerobic Gram-negative rods and anaerobic Gram-positive cocci [ 47 , 73 ]. S. gordonii plays a critical role in initial colonization through the formation of biofilm in the oral environment to which other colonizers can adhere [ 46 , 74 ]. In the present study, the antibacterial properties of ZnCuFe (0.2 wt%) alloys were investigated after exposure to S. gordonii and mixed oral bacteria which may colonialize membranes during GBR applications in the oral cavity.…”

Section: Discussionmentioning

confidence: 99%

“…Considering the later GBR application, the Streptococcus gordonii strain DL1 ( S. gordonii ) and mixed oral bacteria were used. These species, mainly involved in postoperative infections after transoral surgeries, are proposed to reflect the oral environment [ [46] , [47] , [48] ]. Furthermore, S. gordonii and mixed oral bacteria were incubated and collected, as we previously reported in detail [ 46 , 49 ].…”

Section: Methodsmentioning

confidence: 99%

“…Bacteria concentration was quantified by absorption spectroscopy at a wavelength of 620 nm. Bacteria suspension was adjusted to OD value 0.54 at 620 nm, approximately equivalent to 1 × 10 8 bacteria mL −1 [ 46 ]. Furthermore, three samples per group were inoculated with 3 mL diluted bacteria suspension (1 × 10 6 bacteria mL −1 ) in 12-well plates for 12 h at 37 °C and 120 rpm.…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Appropriately adapted properties of hot-extruded Zn–0.5Cu–xFe alloys aimed for biodegradable guided bone regeneration membrane application

Zhang

Li²,

Shen

et al. 2021

Bioactive Materials

Self Cite

View full text Add to dashboard Cite

Appropriately adapted comprehensive mechanical properties, degradation behavior and biocompatibility are prerequisites for the application of Zn-based biodegradable implants. In this study, hot-extruded Zn–0.5Cu–xFe (x = 0.1, 0.2 and 0.4 wt%) alloys were fabricated as candidates for biodegradable materials for guided bone regeneration (GBR) membranes. The hot-extrusion process and Cu alloying were expected mostly to enhance the mechanical properties, and the Fe alloying was added mainly for regulating the degradation. The microstructure, mechanical properties and in vitro degradation behavior were systematically investigated. The ZnCuFe alloys were composed of a Zn matrix and FeZn 13 phase. With increasing Fe content, a higher FeZn 13 phase precipitation with larger particles was observed. Since elongation declined significantly until fracture with increasing Fe content up to 0.4 wt%, the ZnCuFe (0.2 wt%) alloy achieved a good balance between mechanical strength and ductility, with an ultimate tensile strength of 202.3 MPa and elongation at fracture of 41.2%. Moreover, the addition of Fe successfully accelerated the degradation of ZnCuFe alloys. The ZnCuFe (0.2 wt%) alloy showed relatively uniform corrosion in the long-term degradation test. Furthermore, extracts of the ZnCuFe (0.2 wt%) alloy showed no apparent cytotoxic effects against L929 fibroblasts, Saos-2 osteoblasts or TAg periosteal cells. The ZnCuFe (0.2 wt%) alloy exhibited the potential to inhibit bacterial adhesion of Streptococcus gordonii and mixed oral bacteria. Our study provides evidence that the ZnCuFe (0.2 wt%) alloy can represent a promising material for the application as a suitable GBR membrane.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Appropriately adapted properties of hot-extruded Zn–0.5Cu–xFe alloys aimed for biodegradable guided bone regeneration membrane application

Zhang

Li²,

Shen

et al. 2021

Bioactive Materials

Self Cite

View full text Add to dashboard Cite

show abstract

“…Totarol (a natural plant-derived preservative) known for those molecules, can be also used in prophylactic. This substance extracted from Podocarpus totara and placed as a coating agent on a titanium dental implant surface showed significant contact killing and growth-inhibiting effects in the oral bacterial microenvironment after 4, 8, 24 and 48 h of incubation [ 58 ]. Some researchers tried to compare different coating agents amongst themselves.…”

Section: Methods Of Application Of Bioactive Substances Into Surrounding Tissues Of Dental Implantsmentioning

confidence: 99%

Methods of Topical Administration of Drugs and Biological Active Substances for Dental Implants—A Narrative Review

et al. 2021

View full text Add to dashboard Cite

Dental implants are, nowadays, established surgical devices for the restoration of lost teeth. Considered as an alternative for traditional prosthetic appliances, dental implants surpass them in reliability and patient feedback. Local drug delivery around the implants promotes osseointegration and reduces peri-implantitis. However, there are currently no methods of a multiple, precise topical administration of drugs to the implant area. Engineering coatings on the implants, drug application on carriers during implantation, or gingival pockets do not meet all requirements of dental surgeons. Therefore, there is a need to create porous implants and other medical devices that will allow a multiple drug delivery at a controlled dose and release profile without traumatic treatment. Due to the growing demand for the use of biologically active agents to support dental implant treatment at its various stages (implant placement, long-term use of dental superstructures, treatment of the peri-implant conditions) and due to the proven effectiveness of the topical application of pharmacological biologically active agents to the implant area, the authors would like to present a review and show the methods and devices that can be used by clinicians for local drug administration to facilitate dental implant treatment. Our review concludes that there is a need for research in the field of inventions such as new medical devices or implants with gradient solid–porous structures. These devices, in the future, will enable to perform repeatable, controllable, atraumatic, and repeatable injections of active factors that may affect the improvement of osteointegration and the longer survival of implants, as well as the treatment of peri-implantitis.

show abstract

“…The balance will always be key to determining the potential of a coating [ 13 ]. An ideal implant should have both osseointegration and antimicrobial properties [ 4 , 14 ]. There are numerous coatings developed throughout the years with promising results enhancing antimicrobial properties, achieved by either physical or chemical modification or even a combination of both, and we will discuss the most relevant ones.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial and Antibiofilm Coating of Dental Implants—Past and New Perspectives

Esteves

Resende

et al. 2022

Antibiotics

View full text Add to dashboard Cite

Regarded as one of the best solutions to replace missing teeth in the oral cavity, dental implants have been the focus of plenty of studies and research in the past few years. Antimicrobial coatings are a promising solution to control and prevent bacterial infections that compromise the success of dental implants. In the last few years, new materials that prevent biofilm adhesion to the surface of titanium implants have been reported, ranging from improved methods to already established coating surfaces. The purpose of this review is to present the developed antimicrobial and antibiofilm coatings that may have the potential to reduce bacterial infections and improve the success rate of titanium dental implants. All referred coating surfaces showed high antimicrobial properties with effectiveness in biofilm control, while maintaining implant biocompatibility. We expect that by combining the use of oligonucleotide probes as a covering material with novel peri-implant adjuvant therapies, we will be able to avoid the downsides of other covering materials (such as antibiotic resistance), prevent bacterial infections, and raise the success rate of dental implants. The existing knowledge on the optimal coating material for dental implants is limited, and further research is needed before more definitive conclusions can be drawn.

show abstract

Application of totarol as natural antibacterial coating on dental implants for prevention of peri-implantitis

Cited by 26 publications

References 49 publications

Appropriately adapted properties of hot-extruded Zn–0.5Cu–xFe alloys aimed for biodegradable guided bone regeneration membrane application

Appropriately adapted properties of hot-extruded Zn–0.5Cu–xFe alloys aimed for biodegradable guided bone regeneration membrane application

Methods of Topical Administration of Drugs and Biological Active Substances for Dental Implants—A Narrative Review

Antimicrobial and Antibiofilm Coating of Dental Implants—Past and New Perspectives

Contact Info

Product

Resources

About