Application of Traditional Chinese Medical Herbs in Prevention and Treatment of Respiratory Syncytial Virus

Lin, Li; Shan, Jinjun; Xie, Ting; Xu, Jian Ya; Shen, Cun Si; Liu, Di; Chen, Jia Bin; Wang, Shou Chuan

doi:10.1155/2016/6082729

Cited by 31 publications

(26 citation statements)

References 54 publications

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“…Dysregulated or misdirected inflammation is a detrimental factor for pathogenesis of many diseases [ 40 ]. The complementary and alternative approaches have attracted wide concerns for their protective effects against inflammatory responses in many diseases [ 41 ]. In the present study, we explored whether vaccaria hypaphorine exerted a protection from LPS-mediated inflammation in RAW264.7 cells and investigated the underlying mechanism of vaccaria hypaphorine.…”

Section: Discussionmentioning

confidence: 99%

Vaccaria hypaphorine alleviates lipopolysaccharide-induced inflammation via inactivation of NFκB and ERK pathways in Raw 264.7 cells

Sun

Cai

Wang

et al. 2017

BMC Complement Altern Med

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BackgroundActivation of macrophage is involved in many inflammation diseases. Lipopolysaccharide (LPS) is a powerful inflammatory signal contributing to monocytes/macrophages activation associated with increased proinflammatory cytokines expressions. We recently identified that vaccarin was expected to protect endothelial cells from injury. Hypaphorine was abundantly found in vaccaria semen. However, the potential roles and underlying mechanisms of vaccaria hypaphorine on macrophage inflammation have been poorly defined.MethodsThis study was designed to determine the effects of vaccaria hypaphorine on LPS-mediated inflammation in RAW 264.7 cells.ResultsIn this study, we demonstrated that vaccaria hypaphorine dramatically ameliorated LPS-induced nitric oxide (NO) release and productions of proinflammatory cytokines including tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), IL-6, IL-10, monocyte chemoattractant protein 1 (MCP-1) and prostaglandin E2 (PGE2) in RAW 264.7 cells. LPS-stimulated expressions of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) were down-regulated by vaccaria hypaphorine. Furthermore, vaccaria hypaphorine retarded LPS-induced phosphorylation of ERK, nuclear factor kappa beta (NFκB), NFκB inhibitor IκBα, and IKKβ. Immunofluorescence staining revealed that vaccaria hypaphorine eliminated the nuclear translocation of NFκB in LPS-treated RAW 264.7 cells.ConclusionIt was seen that vaccaria hypaphorine counteracted inflammation via inhibition of ERK or/and NFκB signaling pathways. Collectively, we concluded that vaccaria hypaphorine can be served as an anti-inflammatory candidate.Electronic supplementary materialThe online version of this article (doi:10.1186/s12906-017-1635-1) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Vaccaria hypaphorine alleviates lipopolysaccharide-induced inflammation via inactivation of NFκB and ERK pathways in Raw 264.7 cells

Sun

Cai

Wang

et al. 2017

BMC Complement Altern Med

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“…Other herbs like Andrographis paniculata present in south Asia have the strong treating capacity of viral respiratory infection in ayurveda and other medicinal systems (Lin, 2016). Other plants like Sambucus ebulus have been known to inhibit the activity of enveloped viruses and can also be used to ight against novel coronavirus (Ganjhu et al, 2015).…”

Section: Ayurvedamentioning

confidence: 99%

Alternative Medicine Suggestions for Treatment of Covid - 19 -A Review

Jeyashree

Somasundaram

Ganesh

et al. 2020

ijrps

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The health crisis that presently threatens the whole world is COVID-19. The spread of the disease has increased with the number of individuals affected increasing day by day. Currently, many drugs are used all over the world to fight against the disease. Drugs like remdesivir, chloroquine and hydroxychloroquine are used all over the world. Scientists all over the world especially in India are trying to find alternative medicines with minimal side effects to treat this disease. The main aim of this study is to bring alternative medicines for the treatment of COVID - 19 as a consideration to the general public.

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“…Most herbal formulations with viral infection benefits are dedicated to respiratory diseases. Traditional Chinese herbal medicine (TCHM) formulas are by far the most used and play an important role in virus infectious diseases like respiratory syncytial virus infections [34]. TCHM formulas contain a long list of plants and its underlying mechanism is not yet elucidated.…”

Section: Phytotherapy In Viral Infectionsmentioning

confidence: 99%

Are Herbal Products an Alternative to Antibiotics?

Ionescu¹

2018

Bacterial Pathogenesis and Antibacterial Control

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Medicinal plants have been widely used in the management of infectious diseases and by now, many of the ancient remedies have proven their value through scientific methodologies. Although the mechanisms underlying most plant-derived remedies are not well understood, the success of herbal medicine in curing infectious diseases shows that many plants have beneficial effects in various bacterial, fungal, viral or parasitic infections. The modern methodologies in the isolation, purification and characterization of the active compounds, has been a great impact for advancing in vitro and in vivo research, this step being crucial for further application in clinical trials. Many plant-derived compounds, for example, quinine and artemisinin, have been already successfully used in healing lifethreatening infectious disease. The main limitations of plant medicine healing are lack of standardization and reproducibility of plant-derived products. Despite the paucity of clinical trials evaluating their efficacy, phytotherapy, adult plant uses and gemmotherapy, the use of embryonic stem cells should be reconsidered as valuable resources in finding new active compounds with sustained antimicrobial activity.

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Application of Traditional Chinese Medical Herbs in Prevention and Treatment of Respiratory Syncytial Virus

Cited by 31 publications

References 54 publications

Vaccaria hypaphorine alleviates lipopolysaccharide-induced inflammation via inactivation of NFκB and ERK pathways in Raw 264.7 cells

Vaccaria hypaphorine alleviates lipopolysaccharide-induced inflammation via inactivation of NFκB and ERK pathways in Raw 264.7 cells

Alternative Medicine Suggestions for Treatment of Covid - 19 -A Review

Are Herbal Products an Alternative to Antibiotics?

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