Application of vitamin A palmitate eye gel and nurse value of Watson’s theory of caring in children with dry eye after strabismus surgery: a randomized trial

Yang, Suling; Guo, Weina; Gong, Yuexing; Wang, Jian-Cang; Chen, Lu; Zhao, Jingcong; Guo, Xiting; Bai, Jie; Song, Yanxia

doi:10.21037/tp-21-385

Cited by 8 publications

(2 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It also promotes intercellular connections and reverses keratosis of corneal epithelial cells. Vitamin A palmitate eye gel reduces the incidence of dry eye syndrome after strabismus surgery and increases the density of goblet cells, improving dry eye caused by prostaglandin analog [ 39 , 40 ]. Altiparmak et al demonstrated found that 6 months after using artificial tear drops, ST of TAO patients with dry eye syndrome increased from 3.73 ± 1.85 mm to 10.73 ± 5.71 mm and BUT increased from 6.21 ± 1.73 s to 12.9 ± 3.96 s [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

A clinical study of topical treatment for thyroid-associated ophthalmopathy with dry eye syndrome

Sun

Lin

et al. 2023

BMC Ophthalmol

View full text Add to dashboard Cite

Introduction Clinically, thyroid-associated ophthalmopathy (TAO) patients were suffered from dry eye syndrome. Only a few relevant studies were about this topic. Our study was determined to provide high-level evidence for the treatment of TAO with dry eye syndrome. Purpose To compare the clinical effects of vitamin A palmitate eye gel and sodium hyaluronate eye drop forTAO patients with dry eye syndrome. Methods The study was conducted in the Ophthalmology Department of the Ninth People’s Hospital Affiliated with the Medical College of Shanghai Jiao Tong University from May to October 2020. A total of 80 mild or moderate-to-severe TAO patients with dry eye syndrome were randomly divided into two groups. The disease stages of all subjects were inactive. Patients in group A were treated with vitamin A palmitate eye gel three times/day for one month and sodium hyaluronate eye drop in group B. The index including break-up time (BUT) and Schirmer I test (ST), corneal fluorescence staining (FL), ocular surface disease index (OSDI), and adverse reactions were recorded by the same clinician at baseline and 1 month after treatment. The data were analyzed by SPSS 24.0. Results Finally, 65 subjects completed the treatment. The average age of the patients in Group A was 38.1 ± 11.4 years, and that in Group B was 37.26 ± 10.67 years. 82% of the subjects in group A were female and 74% in group B. There was no significant difference between the two groups at baseline, including the value of ST, BUT, OSDI, and FL grade. After the treatment, the effective rate was 91.2% in group A, of which the value of BUT and FL grade was significantly improved (P < 0.001). The effective rate in group B was 67.7%, of which the value of OSDI score and FL grade was significantly improved (P = 0.002). In addition, the BUT value of group A was significantly longer than that of group B (P = 0.009). Conclusion InTAO patients with dry eye syndrome, vitamin A palmitate gel and sodium hyaluronate eye drop improved the dry eye and promoted corneal epithelial repair. Vitamin A palmitate gel improves the stability of tear film, while sodium hyaluronate eye drop improves patients’ subjective discomfort.

show abstract

Section: Discussionmentioning

confidence: 99%

A clinical study of topical treatment for thyroid-associated ophthalmopathy with dry eye syndrome

Sun

Lin

et al. 2023

BMC Ophthalmol

View full text Add to dashboard Cite

show abstract

“…Retinol palmitate ophthalmic solution has also been proven bene cial to the objective signs and subjective symptoms of dry eye syndrome [46] . In addition, vitamin A palmitate eye gel reduces the incidence of dry eye syndrome after strabismus surgery and increases the density of goblet cells, improving dry eye caused by prostaglandin analog [43,47] . Therefore, the present study aimed to evaluate the e cacy and safety of vitamin A palmitate eye gel compared to sodium hyaluronate eye drop in mild or moderate-to-severe inactive TAO patients with dry eye syndrome and provide new evidence for the treatment of dry eye syndrome in TAO.…”

Section: Discussionmentioning

confidence: 99%

A clinical study of topical treatment for thyroid-associated ophthalmopathy with dry eye syndrome

Sun

Lin

et al. 2022

Preprint

View full text Add to dashboard Cite

PurposeTo evaluate the clinical effect of vitamin A palmitate eye gel and sodium hyaluronate eye drop for thyroid-associated ophthalmopathy (TAO) with dry eye syndrome.MethodsThe study was conducted in the Ophthalmology Department of the Ninth People’s Hospital Affiliated with the Medical College of Shanghai Jiao Tong University from May to October 2020. A total of 80 mild or moderate-to-severe inactive TAO patients with dry eye syndrome were divided into the control or the experimental group. Patients in the experimental group were treated with vitamin A palmitate eye gel three times/day for one month and sodium hyaluronate eye drop in the control group. The index of the dry eye test, including break-up time (BUT) and Schirmer I test (SIT), corneal fluorescence staining (FL), ocular surface disease index (OSDI), and adverse reactions were analyzed. The data were analyzed by SPSS 24.0.ResultsAfter the intervention, the effective rate was 67.7% in the control group and 91.2% in the experimental group. The BUT value of the experimental group was significantly longer than that of control group (P=0.009). For the control group, the OSDI score and FL grade were significantly improved after treatment (P=0.002), while BUT score and FL grade were significantly improved after treatment for the experimental group (P<0.001). ConclusionIn patients with TAO, vitamin A palmitate gel and sodium hyaluronate eye drop improved the dry eye and promoted corneal epithelial repair. Vitamin A palmitate gel improves the stability of tear film, while sodium hyaluronate eye drop improves patients’ subjective discomfort.

show abstract

The protective effect of vitamin A palmitate eye gel on the ocular surface during general anaesthesia surgery: a randomized controlled trial

Li,

Lei,

Liu

et al. 2024

Int Ophthalmol

View full text Add to dashboard Cite

Purpose To investigate the change in tear production associated with general anesthesia and the protective effect of vitamin A palmitate eye gel on the ocular surface during general anesthesia. Methods This double-blind, randomized clinical trial included patients undergoing non-ophthalmic surgery under general anesthesia who randomly received vitamin A palmitate eye gel and taping for one eye (Group A, n = 60) or taping alone for the other eye (Group B, n = 60). Symptom assessment in dry eye (SANDE) score, tear film break-up time (TBUT), corneal fluorescein staining (CFS) score, and Schirmer tear test I (STT-1) were analyzed under a hand-held slit lamp before anesthesia (T0), 0.5 h postoperatively (T1), and 24 h postoperatively (T2). Results At 0.5 h postoperatively, an increase in CFS score was observed in both groups (P < 0.05 in Group A and P < 0.01 in Group B), and the participants in Group A had less corneal abrasions than those in Group B. STT-1 significantly increased in Group A (P < 0.05), while it significantly decreased in Group B (P < 0.001). The changes between the two groups were statistically significant (P < 0.001). At 24 h postoperatively, both CFS score and STT-1 almost returned to baseline levels in the two groups. In both groups, the SANDE score and TBUT showed little change at 0.5 h and 24 h postoperatively (all P > 0.05). Conclusion Vitamin A palmitate eye gel effectively protected the ocular surface and aqueous supplementation during general anesthesia. Trial registration This study was registered in the Chinese Clinical Trial Registry (ChiCTR2100052140) on 20/10/2021.

show abstract

Application of vitamin A palmitate eye gel and nurse value of Watson’s theory of caring in children with dry eye after strabismus surgery: a randomized trial

Cited by 8 publications

References 23 publications

A clinical study of topical treatment for thyroid-associated ophthalmopathy with dry eye syndrome

A clinical study of topical treatment for thyroid-associated ophthalmopathy with dry eye syndrome

A clinical study of topical treatment for thyroid-associated ophthalmopathy with dry eye syndrome

The protective effect of vitamin A palmitate eye gel on the ocular surface during general anaesthesia surgery: a randomized controlled trial

Contact Info

Product

Resources

About