Application of β-cyclodextrin in the production of low-cholesterol milk and dairy products

Kolarič, Lukáš; Šimko, Peter

doi:10.1016/j.tifs.2021.11.023

Cited by 25 publications

(10 citation statements)

References 65 publications

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“…In the final, the intermolecular and intramolecular hydrogen bonds cause conformational changes that lead to overall thermodynamic stabilization of the inclusion complexes [27]. One of the most frequent practical applications of inclusion complex formation is the removal of CHO from milk when the formation of the CHO-β-CD inclusion complex provides a fundamental basis to produce functional low cholesterol food products to protect consumers` health against long lasting high daily intake of CHO from milk and dairy products [28]. The same situation was observed also in these experiments, as shown in columns A, B, and C of Table 2, when CHO concentrations were effectively decreased in all treated samples and the average CHO decrease was 92.3%.…”

Section: Resultsmentioning

confidence: 99%

“…The application of the procedure itself is easy, safe, effective, low cost and labour, thus fully realizable on current technological production lines without the need of additional investments and negative effects on nutritional, organoleptic or technological parameters of milk or dairy products. However, the greatest advantage of the procedure is its current usage in dairy industry, albeit for different purpose, i. e. CHO removal [28]. Also, the application of the procedure can prevent effectively to economic losses associated with findings of over limited AFM1 concentrations in traded dairy products [30].…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Decrease of Aflatoxin M<sub>1</sub> Concentration in Milk During Cholesterol Removal by Β-Cyclodextrin Application

Šimko¹,

Kolarič²

2022

Preprint

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Approximately one-third of mankind is chronically exposed to the carcinogenic aflatoxin M1 contained in milk and dairy products and there is no ready to use procedure for decontamination purposes applicable in milk technology. Since β-cyclodextrin is frequently used in food industry, its effect on aflatoxin M1 concentration was investigated during cholesterol removal. So, milk samples were spiked with aflatoxin M1 at the average level 0.89 µg/kg and cholesterol removal was carried out by 2.0% (w/w) β-cyclodextrin addition. As found, average cholesterol concentration decreased by 92.3% while aflatoxin M1 concentration decreased to 0.53 µg/kg, i. e. by 39.1% after the treatment. The procedure itself is easy, inexpensive, and ready to use in milk processing technology on current production lines without any investments, thus fully applicable with a high potential of full aflatoxin M1 milk decontamination efficiency and such way to strengthen considerably the food safety issues associated with milk and dairy products on global level.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Decrease of Aflatoxin M<sub>1</sub> Concentration in Milk During Cholesterol Removal by Β-Cyclodextrin Application

Šimko¹,

Kolarič²

2022

Preprint

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“…The kneading method (also called paste method) is a moderately simple method, which is suitable for poorly water-soluble guests and includes the addition of dissolved solid guest to a slurry of CD to form a paste in a mortar [ 8 ]. A paste is obtained by mixing CDs and water in a vortex mixer, and then guest substances are introduced [ 10 ].…”

Section: Preparation Methods Of Cyclodextrins Inclusion Complexmentioning

confidence: 99%

“…A Web of Science search demonstrates that about 30000 CD journal articles have been reported. Accompanying the rapid development of CD studies, some excellent CD reviews of food science have appeared [ 6 , 7 , 8 , 9 , 10 ]. However, most reviews focus on food nutrition, functionality, and delivery.…”

Section: Introductionmentioning

confidence: 99%

Cyclodextrin Inclusion Complexes and Their Application in Food Safety Analysis: Recent Developments and Future Prospects

Zhou

Jia

et al. 2022

Foods

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Food safety issues are a major threat to public health and have attracted much attention. Therefore, exploring accurate, efficient, sensitive, and economical detection methods is necessary to ensure consumers’ health. In this regard, cyclodextrins (CDs) are promising candidates because they are nontoxic and noncaloric. The main body of CDs is a ring structure with hydrophobic cavity and hydrophilic exterior wall. Due to the above characteristics, CDs can encapsulate small guest molecules into their cavities, enhance their stability, avoid agglomeration and oxidation, and, at the same time, interact through hydrogen bonding and electrostatic interactions. Additionally, they can selectively capture the target molecules to be detected and improve the sensitivity of food detection. This review highlights recent advances in CD inclusion technology in food safety analysis, covering various applications from small molecule and heavy metal sensing to amino acid and microbial sensing. Finally, challenges and prospects for CDs and their derivatives are presented. The current review can provide a reference and guidance for current research on CDs in the food industry and may inspire breakthroughs in this field.

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“…Alonso et al (2019) reported that 5% β-CD was sufficient to eliminate over 80% of cholesterol from the yolk and duck liver. Kolarič and Šimko (2022) summarized that β-CD was also applied to remove cholesterol from commercial milk or cream matrices up to 98%, while the content of other nutritional and flavor components was not significantly affected. Even so, β-CD is still costly, inefficient, and unrecyclable in the commercial food industry; thus, the consequent environmental problems have always been a problem to be solved.…”

Section: β-Cyclodextrinmentioning

confidence: 99%

Polysaccharide‐based biosorbents for cholesterol and bile salts in gastric‐intestinal passage: Advances and future trends

Chen,

He,

et al. 2023

Comp Rev Food Sci Food Safe

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Cholesterol is one of the hazard elements for many cardiovascular diseases, but many cholesterol‐lowering drugs are expensive and unhealthy. Therefore, it is necessary to develop edible and safe biosorbents to reduce excess cholesterol and bile salts in the gastric‐intestinal passage. Polysaccharide‐based biosorbents offer a feasible strategy for decreasing them. This review summarized polysaccharide‐based biosorbents that have been developed for adsorbing cholesterol and bile salts from the gastric‐intestinal passage and analyzed common modification methods for these adsorbents. Finally, the adsorption models were also elucidated. Polysaccharides, including β‐cyclodextrin, pectin, chitin/chitosan, dietary fiber extract, and cellulose, have been proposed for adsorbing cholesterol and bile salts in the gastric‐intestinal passage as biosorbents. This is mainly due to the retention of pores, the capture of the viscosity network, and the help of hydrophobic interactions. In spite of this, the adsorption capacity of polysaccharides is still limited. Therefore, the modifications for them became the most popular areas in the recent studies of in vitro cholesterol adsorption. Chemical approaches namely grafting, (1) acetylation, (2) hydroxypropylation, (3) carboxymethylation, and (4) amination are considered to modify the polysaccharides for higher adsorption ability. Moreover, ultrasonic/microwave/pressure treatment and micron technology (microfluidization, micronization, and ball milling) are effective physical modification methods, while the biological approach mainly refers to enzymatic hydrolysis and microbial fermentation. The adsorption models are generally explained by two adsorption isotherms and two adsorption kinetics. In sum, it is reckoned that further food applications will follow soon.

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Application of β-cyclodextrin in the production of low-cholesterol milk and dairy products

Cited by 25 publications

References 65 publications

Decrease of Aflatoxin M<sub>1</sub> Concentration in Milk During Cholesterol Removal by Β-Cyclodextrin Application

Decrease of Aflatoxin M<sub>1</sub> Concentration in Milk During Cholesterol Removal by Β-Cyclodextrin Application

Cyclodextrin Inclusion Complexes and Their Application in Food Safety Analysis: Recent Developments and Future Prospects

Polysaccharide‐based biosorbents for cholesterol and bile salts in gastric‐intestinal passage: Advances and future trends

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