Applications and limitations of commercially available chiral stationary phases for high-performance liquid chromatography

Däppen, Richard; Arm, H.; Meyer, Veronika R.

doi:10.1016/s0021-9673(00)80205-8

Cited by 134 publications

(17 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These categories are: (1) brush type phases (e. g., Pirkle columns), (2) chiral affinity phases (e.g., protein columns), (3) ligand exchange phases, (4) cavity phases (e.g., cyclodextrins), and (5) polymer phases (e.g., cellulose derivatives). This paper describes a separation using a polymer phase, specifically cellulose with an achiral functionality (benzoate) derivatized onto its hydroxy groups (Fig.…”

mentioning

confidence: 99%

Use of subcritical fluid chromatography for the separation of enantiomers using packed cellulose based stationary phase

et al. 1996

View full text Add to dashboard Cite

Investigations into the parameters affecting the enantiomeric separation of an intermediate in the synthesis of a drug targeted for cardiac arrhythmia is presented. The separation was achieved under subcritical fluid chromatography using CO2 modified with methanol and co‐modifiers isopropyl amine and methylene chloride. The stationary phase was a cellulose based stationary phase manufactured under the trade name Chiracel OB. The results showed the addition of methylene chloride had a noticeable effect on resolution while the separation factor, α, remained constant. The co‐modifier, isopropyl amine, did not considerably influence the resolution, or separation factor. Temperature studies were performed in order to establish the thermodynamic parameters of the interaction between the enantiomers and the stationary phase. Plots of In k′ vs. 1/T proved to be curved, while plots of In α vs. 1/T were linear. © 1996 Wiley‐Liss, Inc.

show abstract

mentioning

confidence: 99%

Use of subcritical fluid chromatography for the separation of enantiomers using packed cellulose based stationary phase

et al. 1996

View full text Add to dashboard Cite

show abstract

“…As mentioned above, the chromatographic separation of enantiomers can be achieved by various methods; however, it is generally desirable to use some type of chiral discriminator or selector [22,23]. Two different types of selectors can be distinguished: a chiral additive in the mobile phase or a chiral stationary phase.…”

Section: Separation Of Chiral Compounds By Hplcmentioning

confidence: 99%

Basic Considerations in HPLC Method Development of Chiral Compounds

Ahuja¹

2010

Chiral Separation Methods for Pharmaceutical and Biotechnological Products

View full text Add to dashboard Cite

“…Dsppen et al [18] (S)-N-(l-Mefhyl-2-oxo-2-phenylefhyl)carbamidsUure-( tert-butyllesfer ((S)-6). Zu 2,6 g (13,7 mmol) BOC-LAlanin ((S)-4) in 150 ml abs.…”

Section: In Analoger Weise Erhielten Wir (+)-(R)-cathinon ((R)-1) Ausmentioning

confidence: 99%

Synthese und Strukturaufklärung von Merucathinon und Synthese von Cathinon. Inhaltsstoffe von Catha edulis FORSK

Wolf

Pfander

1986

Helvetica Chimica Acta

View full text Add to dashboard Cite

show abstract

Applications and limitations of commercially available chiral stationary phases for high-performance liquid chromatography

Cited by 134 publications

References 42 publications

Use of subcritical fluid chromatography for the separation of enantiomers using packed cellulose based stationary phase

Use of subcritical fluid chromatography for the separation of enantiomers using packed cellulose based stationary phase

Basic Considerations in HPLC Method Development of Chiral Compounds

Synthese und Strukturaufklärung von Merucathinon und Synthese von Cathinon. Inhaltsstoffe von Catha edulis FORSK

Contact Info

Product

Resources

About