Applications and literature review of the BI-RADS classification

Obenauer, Silvia; Hermann, K.-P.; Grabbe, E.

doi:10.1007/s00330-004-2593-9

Cited by 113 publications

(95 citation statements)

References 33 publications

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“…8,9 We have observed an architectural distortion (a focal area of breast tissue appears distorted with no definable central mass) and a focal asymmetric density also in our study. From 102 small breast cancers, 14 (14%) were seen as a focal asymmetric density and 4 as an architectural distortion.…”

Section: Discussionsupporting

confidence: 77%

“…This is consistent with results of other published series. [6][7][8][9][10][11][12][13][14] Additional 16/102 (16%) of small breast cancers have mammographic appearance of a round/oval mass without calcifications. Calcifications with/without mass were present in 24/102 (24%) of small breast cancers.…”

Section: Discussionmentioning

confidence: 99%

“…8 All mammographic images were reviewed by a single radiologist (PM), who has a special interest and dedication in breast radiology. Mammographic findings were classified according to Table 2, as seen in Table 1.…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

What is the most common mammographic appearance of T1a and T1b invasive breast cancer?

Podkrajšek¹,

Žgajnar²,

Hočevar³

2008

Radiology and Oncology

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Section: Discussionsupporting

confidence: 77%

Section: Discussionmentioning

confidence: 99%

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What is the most common mammographic appearance of T1a and T1b invasive breast cancer?

Podkrajšek¹,

Žgajnar²,

Hočevar³

2008

Radiology and Oncology

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“…The case-control study included 1,538 patients with breast cancer and 1,605 healthy female controls. We obtained 1,424 cases with mammogram information, which were reviewed and categorized according to the Breast Imaging Reporting and Data System by two radiologists (40,41). The study protocol was approved by the Institutional Review Board (IRB) at the TCIH.…”

Section: Methodsmentioning

confidence: 99%

Functional SNP in the microRNA-367 binding site in the 3′UTR of the calcium channel ryanodine receptor gene 3 ( RYR3 ) affects breast cancer risk and calcification

Zhang

Liu

Song

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

145

106

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We have evaluated and provided evidence that the ryanodine receptor 3 gene (RYR3), which encodes a large protein that forms a calcium channel, is important for the growth, morphology, and migration of breast cancer cells. A putative binding site for microRNA-367 (miR-367) exists in the 3′UTR of RYR3, and a genetic variant, rs1044129 A→G, is present in this binding region. We confirmed that miR-367 regulates the expression of a reporter gene driven by the RYR3 3′UTR and that the regulation was affected by the RYR3 genotype. A thermodynamic model based on base pairing and the secondary structure of the RYR3 mRNA and miR-367 miRNA showed that miR-367 had a higher binding affinity for the A genotype than for the G genotype. The rs1044129 SNP was genotyped in 1,532 breast cancer cases and 1,600 healthy Chinese women. The results showed that compared with the AA genotype, G was a risk genotype for breast cancer development and was also associated with breast cancer calcification and poor survival. Thus, rs1044129 is a unique SNP that resides in a miRNA-gene regulatory loop that affects breast cancer risk, calcification, and survival.

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“…3,[5][6][7][8][9][10][11][12][13][14] However, most radiologists are not comfortable recommending clinical follow-up over surgical excision of radial scars because studies have not consistently demonstrated an upgrade rate of less than 2%, the cutoff for categorizing a lesion as ''probably benign'' according to the BI-RADS (Breast Imaging Reporting and Data System) system (BI-RADS 3). 15 The variability in reported upgrade rates may be due to several factors including variability in study design, small sample sizes, and inconsistent radiologic-pathologic concordance. More importantly, there is currently no definitive study to identify a subset of these patients who may be sufficiently treated without surgical intervention.…”

Section: Commentmentioning

confidence: 99%

Advocating Nonsurgical Management of Patients With Small, Incidental Radial Scars at the Time of Needle Core Biopsy: A Study of 77 Cases

Matrai¹,

D’Alfonso²,

Drotman³

et al. 2015

Archives of Pathology &Amp; Laboratory Medicine

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Context Radial scars are benign sclerosing lesions that are routinely excised when diagnosed in a needle core biopsy. Optimal management for patients with incidental and small (≤5 mm) radial scars is uncertain. Objective To assess pathologic upgrade of radial scars diagnosed in needle core biopsy samples and identify a subset of patients who could benefit from conservative management. Design Patients with a diagnosis of radial scar in a needle core biopsy who underwent excision of the biopsied area were identified. Radial scars greater than 5 mm in size and those with coexisting atypia, carcinoma, and papillary lesions were excluded. After histologic-radiographic correlation, rates of pathologic upgrade were assessed. Results Seventy-seven radial scars diagnosed in 66 patients were included. Overall, 9 of 77 (12%) showed upgrade to a high-risk lesion (6 lobular carcinoma in situ, 2 atypical ductal hyperplasia, 1 atypical lobular hyperplasia), while none (0%) showed upgrade to invasive carcinoma or ductal carcinoma in situ. One of 22 incidental radial scars (4.5%) showed upgrade on excision versus 6 of 36 (16.7%) for radial scars considered to be the radiographic target (P = .23). Older age was associated with upgrade (P < .001). Conclusions No incidental or small (≤5 mm) radial scars excised revealed invasive carcinoma or ductal carcinoma in situ on excision. Provided there is good pathologic-radiologic concordance, it appears reasonable for these patients to be managed conservatively.

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Applications and literature review of the BI-RADS classification

Cited by 113 publications

References 33 publications

What is the most common mammographic appearance of T1a and T1b invasive breast cancer?

What is the most common mammographic appearance of T1a and T1b invasive breast cancer?

Functional SNP in the microRNA-367 binding site in the 3′UTR of the calcium channel ryanodine receptor gene 3 ( RYR3 ) affects breast cancer risk and calcification

Advocating Nonsurgical Management of Patients With Small, Incidental Radial Scars at the Time of Needle Core Biopsy: A Study of 77 Cases

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