Functional SNP in the microRNA-367 binding site in the 3′UTR of the calcium channel ryanodine receptor gene 3 (
            <i>RYR3</i>
            ) affects breast cancer risk and calcification

Zhang, Lina; Liu, Yuexin; Song, Fengju; Zheng, Hong; Hu, Limei; Lü, Hong; Liu, Peifang; Hao, Xishan; Zhang, Wei; Chen, Kexin

doi:10.1073/pnas.1103360108

Cited by 145 publications

(112 citation statements)

References 44 publications

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“…Another study in systemic lupus erythematosus showed that rs1057233 in the 3′UTR of SPI1 was associated with the elevation of SPI1 mRNA level (Hikami et al 2011). Similar results were also found in ovarian cancer (Wynendaele et al 2010) and breast cancer (Zhang et al 2011). The existence of SNPs in miRNA targeting sites may affect the binding affinity of miRNA, thus leads to alter expression of mRNA (Medina and Slack 2008).…”

Section: Discussionsupporting

confidence: 66%

Polymorphisms of microRNA-Binding Sites in Integrin Genes Are Associated with Oral Squamous Cell Carcinoma Susceptibility and Progression

Wang

Long

et al. 2014

Tohoku J. Exp. Med.

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Integrins, which act as an important role in the connection between cells and extra-cellular environments, are important cell surface receptors. Integrins have been demonstrated to play critical roles in many aspects of the progression of oral squamous cell carcinoma (OSCC). The aim of this study was to investigate the association between single nucleotide polymorphisms (SNPs) in microRNA-binding sites of integrin genes and the susceptibility and progression of OSCC in Chinese Han Population. We recruited 167 OSCC patients and 200 cancer-free controls from three independent medical centers. Genotyping was completed successfully for the five selected integrin SNPs: rs1062484 (integrin α3), rs11902171 (integrin α v), rs17468 (integrin β 1), rs3809865 (integrin β 3), and rs2675 (integrin β 5). The results demonstrated that the A allele of rs3809865 T/A (a T-to-A nucleotide change), a functional polymorphism in the 3′UTR of integrin β3 gene, was associated with OSCC risk (p < 0.05). In addition, the association analysis between this SNP and integrin β 3 mRNA expression level in the patients' peripheral blood mononuclear cells indicated that OSCC patients carrying the A allele would have a lower integrin β3 expression level (p = 0.047). Meanwhile, survival analysis showed that the C allele of rs2675 A/C (nucleotide change from A to C), another 3′UTR polymorphism in integrin β5 gene, was related with progression of OSCC. Overall, our results suggest that rs3809865 and rs2675 may contribute to OSCC risk and progression in Chinese Han Population. These two SNPs may be used as potential diagnostic and prognostic biomarkers for OSCC in future.

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Section: Discussionsupporting

confidence: 66%

Polymorphisms of microRNA-Binding Sites in Integrin Genes Are Associated with Oral Squamous Cell Carcinoma Susceptibility and Progression

Wang

Long

et al. 2014

Tohoku J. Exp. Med.

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“…There is abundant evidence that miRNAs, functioning as trans-acting factors, can bind to target genes and play an important role in regulating the development, progression, and metastasis of cancers, including BC (Jazdzewski et al, 2008;Gao et al, 2009;Hollestelle et al, 2011;Zhang et al, 2011). One such miRNA, miR-122, was first recognized as a liver-specific miRNA; it is highly expressed in the liver and is associated with liver-related diseases and hepatocellular carcinoma (HCC).…”

Section: Discussionmentioning

confidence: 99%

A functional insertion/deletion polymorphism in the IL1A gene is associated with decreased risk of breast cancer

Huang

Yang

et al. 2016

Genet. Mol. Res.

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ABSTRACT. The insertion/deletion polymorphism (rs3783553 TTCA/-) in the 3' untranslated region of interleukin-1A (IL1A) has been studied intensively and has been shown to affect tumor risk. We studied the frequency of the IL1A gene polymorphism rs3783553 and evaluated its relationship with breast cancer (BC). A hospital-based case-control study comprising 228 patients with histologically confirmed BC and 241 healthy subjects was conducted. Polymerase chain reaction was used to detect the IL1A rs3783553 polymorphism. The ins/ins (ttca/ttca) genotype was significantly associated with a decreased risk of BC compared with the del/del (-/-) genotype (OR = 0.48, 95% CI = 0.27-0.85). Moreover, the ins (ttca) allele distribution between cases and controls was significantly different from the del (-) allele distribution (OR = 0.74, 95% CI = 0.57-0.96). Thus, the rs3783553 polymorphism is associated with a decreased incidence of breast cancer.

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“…Dysregulation of miR-367 has been found in several types of human malignant tumors, including osteosarcoma (16), glioma (17), breast (18) and esophageal cancer (19). High expression of miR-367 in most of these tumor tissues was closely related to the poor prognosis of patients.…”

Section: Discussionmentioning

confidence: 99%

miR-367 promotes tumor growth by inhibiting FBXW7 in NSCLC

et al. 2017

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Abstract. miR-367 is one of the most abundant miRNAs in human embryonic stem cells (hESCs) and is mainly involved in maintaining the pluripotency of stem cells. However, its role in cancer development remains poorly understood. In the present study, we explored the function and mechanism of the endogenous miR-367 in non-small cell lung cancer (NSCLC). In the present study, we demonstrated that the level of miR-367 in NSCLC was significantly higher than that in adjacent normal tissues, and its upregulation was positively correlated with tumor size, tumor differentiation and tumor-node-metastasis (TNM) stage. miR-367 was an indicator of a poorer prognosis in NSCLC patients. Furthermore, overexpression of miR-367 significantly inhibited apoptosis and enhanced proliferation by promoting cell cycle transition from G1 to S phase. In contrast, knockdown of miR-367 markedly reversed the cellular events observed with miR-367 overexpression. Moreover, we identified that F-box and WD repeat domain-containing 7 (FBXW7) is a novel target of miR-367. It reverses the oncogenic effects of miR-367 by downregulating its substrates, c-Myc and c-Jun, in NSCLC cells. Finally, studies in vivo revealed that knockdown of miR-367 inhibited the growth of xenografts in the nude mice by increasing the expression of FBXW7. In summary, our findings indicate that miR-367 exerts tumorpromoting effect by negatively regulating FBXW7 in NSCLC, and it could become a potential therapeutic target for NSCLC intervention.

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Functional SNP in the microRNA-367 binding site in the 3′UTR of the calcium channel ryanodine receptor gene 3 ( RYR3 ) affects breast cancer risk and calcification

Cited by 145 publications

References 44 publications

Polymorphisms of microRNA-Binding Sites in Integrin Genes Are Associated with Oral Squamous Cell Carcinoma Susceptibility and Progression

Polymorphisms of microRNA-Binding Sites in Integrin Genes Are Associated with Oral Squamous Cell Carcinoma Susceptibility and Progression

A functional insertion/deletion polymorphism in the IL1A gene is associated with decreased risk of breast cancer

miR-367 promotes tumor growth by inhibiting FBXW7 in NSCLC

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