2020
DOI: 10.3389/fchem.2019.00861
|View full text |Cite
|
Sign up to set email alerts
|

Applications and Perspectives of Cascade Reactions in Bacterial Infection Control

Abstract: Cascade reactions integrate two or more reactions, of which each subsequent reaction can only start when the previous reaction step is completed. Employing natural substrates in the human body such as glucose and oxygen, cascade reactions can generate reactive oxygen species (ROS) to kill tumor cells, but cascade reactions may also have potential as a direly needed, novel bacterial infection-control strategy. ROS can disintegrate the EPS matrix of infectious biofilm, disrupt bacterial cell membranes, and damag… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

0
18
0

Year Published

2020
2020
2023
2023

Publication Types

Select...
9

Relationship

4
5

Authors

Journals

citations
Cited by 17 publications
(18 citation statements)
references
References 64 publications
(99 reference statements)
0
18
0
Order By: Relevance
“…Moreover, in inflammatory conditions induced by microbe infection, the pathogens may secrete factors that increase the permeability of blood vessels [106]. Therefore, the nanoparticles with diameters less than 200 nm could passively accumulate at the infected sites due to the enhanced permeability and retention (EPR) effect [107], similar to that found in tumor sites [108]. Upon reaching the sites of infection, the antimicrobial-loaded delivery systems need to penetrate the extracellular polymeric substances of biofilms efficiently and bind to the embedded bacterial cells.…”
Section: Biological Barriersmentioning
confidence: 89%
“…Moreover, in inflammatory conditions induced by microbe infection, the pathogens may secrete factors that increase the permeability of blood vessels [106]. Therefore, the nanoparticles with diameters less than 200 nm could passively accumulate at the infected sites due to the enhanced permeability and retention (EPR) effect [107], similar to that found in tumor sites [108]. Upon reaching the sites of infection, the antimicrobial-loaded delivery systems need to penetrate the extracellular polymeric substances of biofilms efficiently and bind to the embedded bacterial cells.…”
Section: Biological Barriersmentioning
confidence: 89%
“…In a next step however, the encapsulating shell might serve as a container for a non-living, chemically active interior, as in artificial cellular bioreactors [ 33 , 34 ]. For the development of fully engineered probiotic nanoparticles, the chemically active interior could be composed of cascade-reaction components [ 35 ], producing antimicrobials from endogenously present substances in the human body.…”
Section: Discussionmentioning
confidence: 99%
“…Cascade reactions integrate two or more reactions and each completed reaction initiates the next reaction. [ 11 ] For use as a cascade reaction container, G 4 ‐hydrogels were loaded with glucose‐oxidase and hemin, to transform naturally occurring endogenous glucose into H 2 O 2 in the first, glucose‐oxidase assisted reaction. In the subsequent reaction, H 2 O 2 is transformed into ROS with the aid of hemin.…”
Section: Introductionmentioning
confidence: 99%