Applications in Awake Animal Magnetic Resonance Imaging

Ferris, Craig F.

doi:10.3389/fnins.2022.854377

Cited by 25 publications

(20 citation statements)

References 169 publications

(199 reference statements)

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“…In response to these concerns, and in attempt to increase direct translatability of connectivity fMRI, the number of studies employing fMRI in awake rodents have grown over the last few years (54,55). These investigations have shown the possibility of reliably mapping networks in awake restrained (56) or headfixed(57) animals, with minimal stress and motion-related artefacts.…”

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

Modeling Brain Dysconnectivity in Rodents

Gozzi

Zerbi²

2023

Biological Psychiatry

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Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

Modeling Brain Dysconnectivity in Rodents

Gozzi

Zerbi²

2023

Biological Psychiatry

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“…Radio frequency signals were sent and received with a quadrature volume coil built into the animal restrainer (Ekam Imaging Inc., Boston, MA, USA). The design of the restraining system included a padded head support obviating the need for ear bars helping to reduce animal discomfort while minimizing motion artifact ( Ferris et al, 2014 ; Ferris, 2022 ). All mice were imaged while under light 1% isoflurane anesthesia for a maximum of one hour.…”

Section: Methodsmentioning

confidence: 99%

Chronic exposure to inhaled vaporized cannabis high in Δ9-THC alters brain structure in adult female mice

Taylor

Nweke²,

Vincent³

et al. 2023

Front. Neurosci.

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IntroductionThe medical and recreational use of cannabis has increased in the United States. Its chronic use can have detrimental effects on the neurobiology of the brain—effects that are age-dependent. This was an exploratory study looking at the effects of chronically inhaled vaporized cannabis on brain structure in adult female mice.MethodsAdult mice were exposed daily to vaporized cannabis (10.3% THC and 0.05% CBD) or placebo for 21 days. Following cessation of treatment mice were examined for changes in brain structure using voxel-based morphometry and diffusion weighted imaging MRI. Data from each imaging modality were registered to a 3D mouse MRI atlas with 139 brain areas.ResultsMice showed volumetric changes in the forebrain particularly the prefrontal cortex, accumbens, ventral pallidum, and limbic cortex. Many of these same brain areas showed changes in water diffusivity suggesting alterations in gray matter microarchitecture.DiscussionThese data are consistent with much of the clinical findings on cannabis use disorder. The sensitivity of the dopaminergic system to the daily exposure of vaporized cannabis raises concerns for abuse liability in drug naïve adult females that initiate chronic cannabis use.

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“…During MRI scanning, the state of the animal can be classified as awake or anesthetized (Figure 2A). Awake imaging does not need an anesthetic during the scan, which usually achieves stable imaging through early adaptive training and restriction devices in different animals (Ferris, 2022). Under certain circumstances, a faster scan sequence (fast low-angle shot, FLASH) may be used to obtain a sharper image (Tsurugizawa et al, 2009b(Tsurugizawa et al, , 2010.…”

Section: Methods Of Animal Anesthetization For Scanningmentioning

confidence: 99%

The current status and trend of the functional magnetic resonance combined with stimulation in animals

Huang

Zhang

et al. 2022

Front. Neurosci.

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As a non-radiative, non-invasive imaging technique, functional magnetic resonance imaging (fMRI) has excellent effects on studying the activation of blood oxygen levels and functional connectivity of the brain in human and animal models. Compared with resting-state fMRI, fMRI combined with stimulation could be used to assess the activation of specific brain regions and the connectivity of specific pathways and achieve better signal capture with a clear purpose and more significant results. Various fMRI methods and specific stimulation paradigms have been proposed to investigate brain activation in a specific state, such as electrical, mechanical, visual, olfactory, and direct brain stimulation. In this review, the studies on animal brain activation using fMRI combined with different stimulation methods were retrieved. The instruments, experimental parameters, anesthesia, and animal models in different stimulation conditions were summarized. The findings would provide a reference for studies on estimating specific brain activation using fMRI combined with stimulation.

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Applications in Awake Animal Magnetic Resonance Imaging

Cited by 25 publications

References 169 publications

Modeling Brain Dysconnectivity in Rodents

Modeling Brain Dysconnectivity in Rodents

Chronic exposure to inhaled vaporized cannabis high in Δ9-THC alters brain structure in adult female mice

The current status and trend of the functional magnetic resonance combined with stimulation in animals

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