Every day, mining corporations grow and develop over Egypt’s Eastern Desert in search of gold, silver, and other metals. Mineral resources in Egypt are a powerful tool for increasing national income. In this study, we are interested in mineral exploration, such as gold and porphyry deposits, using aeromagnetic data, applying various processing techniques such as First Vertical Derivative, Total Horizontal Gradient, Analytical Signal, Tilt Derivative, and the center of exploration targeting. The study area is located at the Central Eastern Desert, which includes the Barramiya, Abu Marwa, and Abu Mireiwah regions. The analysis of the delineated structural trends shows that the N–S, NW–SE, and NE–SW are the most effective directions for managing deposits in the investigated area. A minor trend is also shown in the E–W direction and corresponds to the alteration zones reported by geology and prior investigations. Mineralization zones occur most frequently at the contact between ophiolitic serpentinite, sediments, and other rock types. This study intends to add more about the use of the recently developed technology of CET grid analysis for mineral exploration and structural interpretation across the Central Eastern Desert. The CET porphyry analysis map shows locations where several occurrences of porphyry deposits are probable. The newly discovered spots are similar to the area’s usual deposit sites. This study proves that aeromagnetic data are significant in mineral exploration since they are useful for the discovery of the structure and shear zones controlling the mineralization zones.