Applications of chitosan nanoparticles to enhance absorption and bioavailability of tea polyphenols: A review

Liang, Jin; Yan, Hua; Puligundla, Pradeep; Gao, Xueling; Zhou, Yibin; Wan, Xiaochun

doi:10.1016/j.foodhyd.2017.01.041

Cited by 252 publications

(118 citation statements)

References 60 publications

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“…Flocculants work in bridging the scattered flocs into a larger aggregation by particular mechanisms (i.e., density charging, ionic strengthening, and electrostatic patching), which afford the collision between the chitosan and the particles in suspension . Flocculant characteristics such as high molecular weight, chain length, and high dosage are intrinsic factors that support flocculation performance . Figure shows CF performance on BL in decolourization and generating sludge.…”

Section: Resultsmentioning

confidence: 99%

The enhancement of black liquor treatment by applying a natural flocculant and converting its sludge to a high‐benefit product

Amriani

Bani²,

Muryanto

et al. 2018

Can J Chem Eng

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Black liquor (BL) as lignocellulosic-based industrial wastewater is largely attained from a chemical pretreatment process. When treated with the commonly used coagulant polyaluminum chloride (PACl), BL was decolourized but its pH decreased drastically from 13 to 4-5. Chitosan as a natural flocculant was added to the BL treatment process to support the PACl. The combination of coagulant-flocculant (PACl-Chitosan) effectively generated sludge, rejuvenated the treated BL pH level to neutral, and decolourized and reduced several parameters required for the treated BL disposal. To establish a sustainable recycling process and enhance the BL treatment, the generated sludge as a potential source was recovered and converted to a carbonaceous adsorbent (CA) by applying a two-stage carbonization process, heat and steam carbonization, during which the temperature and time in the first stage of the heat-carbonization process differ. The first BL sludge-based CA (BLS-CA 1) is produced by employing the first stage heating at 575 8C for 180 min while the second black liquor sludge-based CA (BLS-CA 2) is produced by employing the first stage heating at 450 8C for 60 min. Both CAs were able to adsorb about 99 % methylene blue (MB) at MB concentration 100 mg/L for 16 h though they have smaller surface areas than commercially activated carbon, which is only able to adsorb about 70 % MB at the same concentration and adsorption time. This study demonstrates a potential way to reduce the emerging problem from the generated sludge through a sustainable recycling process as well as BL treatment.

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Section: Resultsmentioning

confidence: 99%

The enhancement of black liquor treatment by applying a natural flocculant and converting its sludge to a high‐benefit product

Amriani

Bani²,

Muryanto

et al. 2018

Can J Chem Eng

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“…Nanostructured biomaterials have been demonstrated to have the potential to promote the intestinal transportation of phytochemicals by the encapsulation and thus improve the bioavailability (Zhang, Zhang, et al, ). Moreover, nanoparticles can also increase the effects of active constituents and decrease the side effects with the ability to control and sustain the release of bioactive molecules (Liang et al, ). Natural polymers such as proteins, lipid and polysaccharides can be used to load flavonoids and form nanocomplexes (Zhang, Zhang, et al, ).…”

Section: Chemical Structures and Bioavailability Of Flavonoidsmentioning

confidence: 99%

The modulatory effect and the mechanism of flavonoids on obesity

Liu

Zhang

et al. 2019

J Food Biochem

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With the improvement of living standards, obesity has become a serious health problem all over the word. Currently, the methods and drugs for obesity treatment have some limitations and side effects. Flavonoids are active constituents with various biological activities, widely found in plants, and numerous studies have shown that flavonoids can inhibit obesity and related metabolism disorders effectively. This perspective reviews the recent progress in understanding the anti‐obesity effects of flavonoids through modulating food intake, enzyme activities, nutrition absorption, adipogenesis and adipocyte lifecycle, thermogenesis, energy consumption, and intestinal microbiota. Practical applications Natural bioactive substance flavonoids have anti‐obesity property, which may play a role in anti‐obesity drugs or functional food without any side effects. Flavonoids can inhibit weight gain directly or through their biologically active metabolites by various potential pathways. A better understanding of the modulatory effect and the mechanism of flavonoids on obesity will allow us to better utilize flavonoids in plants to treat obesity and related metabolic syndrome.

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“…Although the GIT is designed (evolved) to prevent uptake of particulate matter (e.g. potentially toxic materials and pathogens) from the environment, it is not a completely prohibitive barrier [9][10][11] . The chemical composition of mucus provides an opportunity for both acidic and basic compounds to interact with it, thereby increasing the residence time of both drugs and NPs in close proximity to the absorptive surfaces.…”

Section: Gastrointestinal Tract (Git) Physiology With Relevance To Pamentioning

confidence: 99%

Untitled

2017

IJPSR

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Peptide drugs are poorly absorbable and are also susceptible to enzymatic degradation in the gastrointestinal tract (GIT). To overcome the physiological and morphological barriers for the peptide / poorly absorbable drug delivery, mucopenetrative and mucoadhesive properties of drug carriers have to be considered. Mucoadhesion can prolong the residence time of drug carriers at the absorption sites, improved drug absorption and controlled release of drug from the device used. The particles with smaller size were likely to diffuse much faster into the mucus layer, provided that diffusion of the particles into the mucus layer should obey Stokes-Einstein equation. The adhesiveness of the nanoparticles (NPs) in suspension form helps to improve bioavailability. Chitosan (CS) based or CS-coated NPs represent another common group of mucoadhesive systems. Moreover, NPs made of such polymers were used to enhance the bioavailability, and also the mucoadhesion of proteins, peptides and DNA to the mucosal tissues. This review focuses on the mechanism of gastrointestinal mucoadhesion of NPs for peptide/poorly absorbable drugs.

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Applications of chitosan nanoparticles to enhance absorption and bioavailability of tea polyphenols: A review

Cited by 252 publications

References 60 publications

The enhancement of black liquor treatment by applying a natural flocculant and converting its sludge to a high‐benefit product

The enhancement of black liquor treatment by applying a natural flocculant and converting its sludge to a high‐benefit product

The modulatory effect and the mechanism of flavonoids on obesity

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