Applications of Fourier transform infrared spectroscopy to pharmaceutical preparations

Song, Yijie; Cong, Yuanhua; Wang, Bing; Zhang, Ning

doi:10.1080/17425247.2020.1737671

Cited by 53 publications

(14 citation statements)

References 137 publications

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“…An obvious decrease wave of −NH stretching and an increase in −CO vibration was found in EsA and CS, showing the specific interaction in ALG with EsA and CS. It was indicated that the carboxyl group (COO – ) in ALG interacted with the amino group (NH3 + ) in CS and EsA, and the carboxyl group of EsA was coated with Ca 2+ and EsA, which formed strong ionic bonds in the formed hybrid nanoparticles. , DSC was used to determine the thermal properties of the encapsulated EsA in the formed nanoparticles. Figure D reveals the DSC waveform of EsA, ALG, CS, and EsA-CS/ALG-NPs.…”

Section: Resultsmentioning

confidence: 99%

“…It was indicated that the carboxyl group (COO − ) in ALG interacted with the amino group (NH3 + ) in CS and EsA, and the carboxyl group of EsA was coated with Ca 2+ and EsA, which formed strong ionic bonds in the formed hybrid nanoparticles. 41,42 DSC was used to determine the thermal properties of the encapsulated EsA in the formed nanoparticles. Figure 2D…”

Section: Preparation Of Esa-cs/alg-npsmentioning

confidence: 99%

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Chitosan/Alginate Nanoparticles with Sustained Release of Esculentoside A for Burn Wound Healing

Zhu

Shao

et al. 2023

ACS Appl. Nano Mater.

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Burn injury remains one of the most devastating burdens on global public health. The inflammation, caused by burn injury and transplantation of dermal scaffolds, often leads to delayed burn wound healing. Esculentoside A (EsA), with a strong anti-inflammatory capacity, is an available agent that might contribute to the treatment of burn wounds. However, the poor stability and toxicity of EsA limit its clinical application. In the present study, we constructed chitosan/alginate nanoparticles (EsA-CS/ALG-NPs) to improve sustainability and reduce toxicity followed by impregnation of the prepared EsA-CS/ALG-NPs into a collagen/chitosan scaffold (EsA-CS/ALG-NPs@CCS). The particle size, structural morphology, thermal properties, and chemical interaction of repaired nanoparticles were evaluated using the Nanometrics instrument, differential scanning calorimetry, transmission electron microscopy, and Fourier transform infrared spectroscopy, respectively. The hybrid EsA-CS/ALG-NPs@CCS was evaluated for physical characteristics, in vitro drug release, biocompatibility, and anti-inflammation capacity with RAW 264.7 cells and in vivo burn wound healing studies with SD rats. The results showed that we successfully constructed CS/ALG-NPs and optimized the preparation process to achieve the highest encapsulation efficiency. The hybrid EsA-CS/ALG-NPs@CCS, with reduced cytotoxicity and sustained release of EsA, could alleviate inflammation, decrease the ratio of M1 macrophages, and increase the proportion of M2 macrophages in vitro. It was demonstrated that 5 μg EsA CS/ALG-NPs@CCS not only reduces inflammatory cytokines secretion and inhibits M1 macrophages but also promotes the release of anti-inflammatory cytokines and activates M2 macrophages, thereby achieving accelerated and high-quality healing of burn wounds ultimately. In summary, our work suggests that the synergistic combination of EsA, nanoparticles, and scaffolds provided a promising strategy for treating burn injuries.

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Section: Resultsmentioning

confidence: 99%

Section: Preparation Of Esa-cs/alg-npsmentioning

confidence: 99%

Chitosan/Alginate Nanoparticles with Sustained Release of Esculentoside A for Burn Wound Healing

Zhu

Shao

et al. 2023

ACS Appl. Nano Mater.

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“…These techniques are extensively utilized in the study of pharmaceutical solids to characterize amorphous and crystalline phases, identify the structure and composition of different pharmaceutical solid forms, determine the compatibility of mixtures, and establish molecular interactions [42].…”

Section: Vibrational Spectroscopic Techniquesmentioning

confidence: 99%

Pharmaceutical Crystals: Development, Optimization, Characterization and Biopharmaceutical Aspects

Bongioanni¹,

Bueno²,

Mezzano³

et al. 2023

Crystal Growth and Chirality - Technologies and Applications

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In the solid state, the active pharmaceutical ingredients tend to exhibit crystalline order. In this regard, the interest in the crystalline solid state has expanded to include single-component compounds as well as multicomponent systems such as salts, hydrates, solvates, and co-crystals. The study of crystalline behavior is recognized as an essential component of preformulation research in pharmaceutical sciences and industries. The crystalline form can impact the drug properties such as solubility, dissolution rate, stability, hygroscopicity, and toxicity profile. Therefore, each solid form must be appropriately identified and characterized because it will affect the drug formulation, including the pharmacokinetic, pharmacodynamic, and safety properties of the formulation. In this context, this chapter will cover topics such as synthesis approaches (including nucleation and crystallization procedures), crystal polymorphism, solid state characterization techniques and the impact of crystals on physicochemical and biopharmaceutical properties.

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“…The compatibility and potential interactions between the SMSD-TQM components were evaluated using FT-IR analysis [30]. The samples were individually placed on the sample platform of the instrument (Shimadzu, IR Spirit, Japan), and IR spectra were acquired using LC Solution software in the wavenumber range of 4000-600 cm -1 .…”

Section: Fourier Transform Infrared Spectroscopy (Ft-ir)mentioning

confidence: 99%

Self-Micellizing Solid Dispersion of Thymoquinone with Enhanced Biopharmaceutical and Nephroprotective Effects

Halder¹,

Afrose²,

Shill³

et al. 2023

Preprint

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The present study was designed to develop a self-micellizing solid dispersion (SMSD) containing Thymoquinone (TQM), a phytonutrient obtained from Nigella sativa seeds, aiming to improve its biopharmaceutical and nephroprotective functions. The apparent solubility of TQM in polymer solutions was used to choose an appropriate amphiphilic polymer that could be used to make an SMSD system. Based on the apparent solubility, Soluplus® was chosen as an appropriate carrier, and mixing with TQM, SMSD-TQM with different loadings of TQM (5–15%) was made by solvent evaporation and freeze-drying techniques, respectively, and the formulations were optimized. The optimized SMSD-TQM was evaluated in terms of particle size distribution, morphology, release characteristics, pharmacokinetic behavior, and nephroprotective effects in a rat model of acute kidney injury. SMSD-TQM significantly improved the dissolution characteristics (97.8%) of TQM in water within 60 min. Oral administration of SMSD-TQM in rats exhibited a 4.9-fold higher systemic exposure than crystalline TQM. In a cisplatin-induced (6 mg/kg, i.p.) acute kidney-damaged rat model, oral SMSD-TQM (10 mg/kg) improved the nephroprotective effects of TQM based on the results of kidney biomarkers and histological abnormalities. These findings suggest that SMSD-TQM might be efficacious in enhancing the nephroprotective effect of TQM by overcoming biopharmaceutical limitations.

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Applications of Fourier transform infrared spectroscopy to pharmaceutical preparations

Cited by 53 publications

References 137 publications

Chitosan/Alginate Nanoparticles with Sustained Release of Esculentoside A for Burn Wound Healing

Chitosan/Alginate Nanoparticles with Sustained Release of Esculentoside A for Burn Wound Healing

Pharmaceutical Crystals: Development, Optimization, Characterization and Biopharmaceutical Aspects

Self-Micellizing Solid Dispersion of Thymoquinone with Enhanced Biopharmaceutical and Nephroprotective Effects

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