Applications of GnRH in the control and management of fertility in female animals

Herbert, Catherine A.; Trigg, T. E.

doi:10.1016/j.anireprosci.2005.05.007

Cited by 90 publications

(56 citation statements)

References 33 publications

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“…It was revealed that long-term LA administration causes an increase in body weight in rats compared with that in the control group. This subsequent effect has been reported in humans mainly in treatments for precocious puberty using GnRH and LA (18,19), as well as cancer (20,21) and fertility regulation (22,23).…”

Section: Discussionmentioning

confidence: 78%

Changes in body composition and mRNA expression of ghrelin and lipoprotein lipase in rats treated with leuprolide acetate, a GnRH agonist

et al. 2017

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Abstract. Leuprolide acetate (LA), a gonadotropin-releasing hormone (GnRH) agonist, was identified to cause changes in body weight in experimental and clinical trials; however, to date, the effect of LA on the body composition has not been properly assessed. The aim of the present study was to evaluate the long-term effect of LA administration on body composition and the mRNA expression of ghrelin and lipoprotein lipase (LPL) in rats. Ovariectomized (OVX), ovariectomized and LA-treated (OVX+LA), non-ovariectomized (CTRL) and non-ovariectomized but LA-treated (LA) rats were used. LA treatment was performed by intramuscular injection at 5 µg/kg every 72 h over 120 days. Analysis of body composition and mRNA expression of ghrelin and lipoprotein lipase were performed. The results indicated significant changes in body composition after treatment; in the OVX, LA, OVX+LA and CTRL group, the body weight was increased by 216.1, 183.7, 175.4 and 150.1%, respectively, compared with baseline. The fat mass in the LA group was 14% higher than that in the CTRL group, while that in the OVX group was 19% higher than that in the OVX+LA, and the fat-free mass was similar between the LA and CTRL as well as the OVX and OVX+LA groups. Following 120 days of treatment, the mRNA expression of ghrelin and LPL in the LA group was ~20% higher than that in the CTRL group, while that in the OVX+LA was downregulated in comparison with that in the OVX group. The results of the present study confirmed changes in body composition and mRNA expression of ghrelin and LPL caused by long-term administration of LA. LA may contribute to regulate food consumption and exert control over adipogenesis.

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Section: Discussionmentioning

confidence: 78%

Changes in body composition and mRNA expression of ghrelin and lipoprotein lipase in rats treated with leuprolide acetate, a GnRH agonist

et al. 2017

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“…The rationale of this treatment is to block the GnRH receptors by using GnRH antagonists with longer half life and higher affinity for the receptor than the endogenous GnRH, inhibiting its action and thus suppressing gonadotropin release. A preliminary study has reported that the subcutaneous administration of acycline at 110 μg/ kg within the first 3 days of proestrus resulted in a short, anovulatory estrus with return to proestrus within 3 weeks of treatment (LOPEZ; MACEDO, 2004;HERBERT;TRIGG, 2005). The use of GnRH antagonists in pet animals is promising.…”

Section: Conservative Treatment/management Of Orsmentioning

confidence: 99%

“…The internalization of the GnRH receptors following binding of GnRH conjugated to the toxin provides a selective way to disrupt the pituitary gonadotrops by damaging them in sufficient number to cease the reproductive function (SABEUR et al, 2003). Although the GnRH-toxin technology provides an interesting alternative to surgical sterilization its use in pets requires further investigation (HERBERT;TRIGG, 2005).…”

Section: Conservative Treatment/management Of Orsmentioning

confidence: 99%

Ovarian remnant syndrome in small animals

et al. 2012

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The ovarian remnant syndrome (ORS) is an iatrogenic disorder in bitches and queens, which is characterized by recurrence of estrus following surgical spay, due to the presence of a piece of ovarian tissue within the abdominal cavity. In most cases, the remnant ovary is found in the right ovarian pedicle, due to its topographic position, deeper and more cranial than the left ovary. The main clinical signs of ORS in small animals are the heat behavior and the presence of vaginal swelling/secretion, especially in canines. The diagnosis should be performed by means of vaginal cytology when attraction of males is detected, serum estrogen and progesterone levels and/or by challenging test with GnRH or hCG administration. However, vaginal citology is the most suitable and less expensive diagnostic tool. Nowadays the treatment of choice is a new laparotomy or laparoscopy, followed by removal of the remnant ovarian tissue. The surgical treatment has more chances of success if it is performed in the diestrus (i.e., between 15 and 60 days after the detection of attraction of males). Furthermore, a careful and accurate surgical procedure aided by advanced visualization techniques during ovariohysterectomy or ovariectomy is the best way to prevent ORS in companion animals. Key words: Partial ovarian spay, recurrent estrus, bitches, queens ResumoA síndrome do ovário remanescente (SOR) é um distúrbio iatrogênico em cadelas e gatas caracterizado pelo retorno do estro após contracepção cirúrgica devido à presença de fragmento de tecido ovariano na cavidade abdominal. Frequentemente, o ovário remanescente está situado no pedículo ovariano direito, sobretudo devido a sua posição topográfica mais profunda e cranial em comparação ao ovário esquerdo. Os principais sinais clínicos de SOR em pequenos animais são cio e presença de edemaciamento/secreção vulvar/vaginal, especialmente em caninos. O diagnóstico deve ser realizado por meio de citologia vaginal quando detecta-se o interesse dos machos pela cópula com a fêmea acometida, dosagem sérica de estrógeno e progesterona e/ou por meio do teste provocativo com administração de GnRH ou hCG. Contudo, citologia vaginal constitui a opção de melhor custo-benefício para o diagnóstico. Atualmente, o tratamento de escolha é cirúrgico por meio de laparotomia exploratória ou laparoscopia, seguido pela remoção do ovário remanescente. O tratamento cirúrgico tem maiores taxas de sucesso quando realizado com o animal em diestro (i.e., entre 15 e 60 dias após detectada a atração dos machos). Ademais, a

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“…Because the use of those drugs are more diffi cult due to their side eff ects such as breast tumors, pyometra, acromegalic changes, diabetes, adrenocorti cal suppression, masculinity in female fetuses, local skin reacti ons, bradycardia, hypersalivati on and vomiti ng, GnRH agonists (desloreline, nafareline), which indirectly suppress the secreti on of LH and FSH, are frequently used to suppress cyclic acti vity in bitches [12][13][14][15] . In bitches, LH is necessary as a luteotropic hormone for the luteal secreti on of P4 throughout pregnancy…”

Section: 6-12mentioning

confidence: 99%

Köpeklerde Gebeliğin Sonlandırılması Amacıyla GnRH Agonisti (Desloreline) ile PGF2Kombinasyonunun Kullanımı

Güngör¹,

Kaya²,

Gürbulak³

et al. 2009

Kafkas Univ Vet Fak Derg

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SummaryTen bitches whose sexual cycle periods were determined with vaginal cytology to be mated at appropriate time were used in this study. Desloreline implant (Suprelorin®) was inserted under the dorsal skin of bitches that were determined to be pregnant using ultrasonography 20 days after the first day of mating. Ten days after the implant insertion, single dose PGF2 (cloprostenol, 20 μg/kg, IM) was administered. The pregnancy was terminated on all bitches that received this procedure. It was determined that the level of progesterone decreased from an average of 28.87±11.86 ng/ml on the day of implant insertion (day 20-21 of pregnancy) to 0.43±0.31 ng/ml when the abortion was completed. It was observed that after the implant insertion, the abortion was completed in an average of 3.9±0.7 days following PGF2 administration. It has been observed that abortions was completed in an average of 2,3±0.48 days after the first vaginal discharge was seen. In conclusion, it was determined that Desloreline, a GnRH agonist, successfully could terminate pregnancy when it is combined with a single dose of PGF2 administration in bitches.Keywords: Bitch, Pregnancy termination, Desloreline, PGF2 Köpeklerde Gebeliğin Sonlandırılması Amacıyla GnRH Agonisti (Desloreline) ile PGF2Kombinasyonunun Kullanımı ÖzetAraştırmada seksüel siklus evresi vaginal sitoloji ile belirlenerek en uygun zamanda çiftleştirilen on dişi köpek kullanıldı. İlk çiftleştirme gününü takiben 20. günden itibaren yapılan ultrases muayenesi ile gebe olduğu belirlenen köpeklere Suprelorin® boyun derisi altına yerleştirildi. İmplantın yerleştirilmesini takiben 10. günde bir kereye mahsus olmak üzere PGF2 (cloprostenol, 20 μg/kg,) kas içi yolla uygulandı. Uygulama yapılan köpeklerin tümünde gebelik sonlandı. Progesteron değerinin implantın uygulandığı gün (gebeliğin 20-21. günü), ortalama 28.87±11.86 ng/ml iken, abortion tamamlandığında ortalama 0.43±0.31 ng/ml'ye düştüğü belirlendi. İmplant uygulamasından 10 gün sonra enjekte edilen PGF2'yı takiben ortalama 3.9±0,7 günde köpeklerde abortionun tamamlandığı görüldü. Abortionun vajinal akıntının ilk kez görülmesinden sonra 2.3±0.48 gün içinde tamamlandığı belirlendi. Sonuç olarak, uzun etkili GnRH anoloğu olan Deslorelin'in köpeklerde tek doz PGF2 uygulaması ile birlikte kombine edildiğinde gebeliği başarılı olarak sonlandırabildiği belirlendi

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Applications of GnRH in the control and management of fertility in female animals

Cited by 90 publications

References 33 publications

Changes in body composition and mRNA expression of ghrelin and lipoprotein lipase in rats treated with leuprolide acetate, a GnRH agonist

Changes in body composition and mRNA expression of ghrelin and lipoprotein lipase in rats treated with leuprolide acetate, a GnRH agonist

Ovarian remnant syndrome in small animals

Köpeklerde Gebeliğin Sonlandırılması Amacıyla GnRH Agonisti (Desloreline) ile PGF2Kombinasyonunun Kullanımı

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