Applications of Gold Nanoparticles in Non-Optical Biosensors

Jiang, Peipei; Wang, Yulin; Zhao, Lu; Ji, Chenyang; Chen, Dongchu; Nie, Libo

doi:10.3390/nano8120977

Cited by 102 publications

(52 citation statements)

References 187 publications

(194 reference statements)

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“…AuNPs have gained attention during the last decades because of their unique properties, like Surface Plasmon Resonance (SPR), non-toxicity, biocompatibility and stability, which have made them a very attractive material for biosensor systems [5][6][7][8]. Moreover, many researchers have investigated the role of AuNPs in the areas of electronics [9,10], biomedical [11,12], catalytic [13][14][15], food technology [16][17][18] and also solar cells for high performance applications [19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Low-cost synthesis of AuNPs through ultrasonic spray pyrolysis

Tiyyagura

Majerič

Anžel

et al. 2020

Mater. Res. Express

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The present research informs about the synthesis of gold nanoparticles (AuNPs) through Ultrasonic Spray Pyrolysis (USP), which were collected in ethanol with 0.1% Polyvinylpyrrolidone (PVP). Initially, the research focused on two precursors, where the first represented a homemade H-HAuCl 4 , completed in our own laboratory through the chlorine gas method by using HCl and KMnO 4 , and the second was the commercial C-HAuCl 4 , prepared by using Gold (III) chloride tetrahydrate powder and deionised water. The goal was to find any potential precursor differences and their influences on the later use for AuNPs synthesis through USP using almost the same parameters. In the first step of research it was determined that the H-HAuCl 4 precursor was similar to C-HAuCl 4 in chemical composition, surface tension and pH value. This finding represented the starting point for being able to use H-HAuCl 4 in the USP for AuNPs' synthesis. In the second step, AuNPs were synthesised from both types of precursors. Afterwards, characterisation of some functional properties by FTIR and UVvis techniques was done directly for H-and C-AuNPs in the collecting media. For SEM/EDX and TEM microscopy both types of H-and C-AuNPs were dried, and observation revealed that the morphology, shape and size distribution of dried AuNPs were very similar. Based on the performed laboratory research, it could be concluded that prepared H-AuNPs could represent a new and lowcost effective solution for future USP transfer onto the industrial level, not only in in the process itself, but also in the field of Low-cost Precursor Preparation.Abbreviations

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Section: Introductionmentioning

confidence: 99%

Low-cost synthesis of AuNPs through ultrasonic spray pyrolysis

Tiyyagura

Majerič

Anžel

et al. 2020

Mater. Res. Express

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“…Some nanomaterials have intrinsic properties that facilitate their use as electrochemical labels, which is a desirable characteristic for reducing time and complexity of measurements. Among all the nanomaterials, AuNPs have been the most extensively studied, as they are easy to synthesize and bioconjugate with antibodies [ 91 ]. Owing to their high surface-to-volume rate in particles between 1–100 nm and high surface energy, they favor the immobilization of biological recognition elements [ 92 ].…”

Section: Electrochemical Biosensors For Alzheimer’s Disease Diagnomentioning

confidence: 99%

Electrochemical Biosensors Based on Nanomaterials for Early Detection of Alzheimer’s Disease

Toyos-Rodríguez

Alonso

Escosura‐Muñiz

2020

Sensors

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Alzheimer’s disease (AD) is an untreatable neurodegenerative disease that initially manifests as difficulty to remember recent events and gradually progresses to cognitive impairment. The incidence of AD is growing yearly as life expectancy increases, thus early detection is essential to ensure a better quality of life for diagnosed patients. To reach that purpose, electrochemical biosensing has emerged as a cost-effective alternative to traditional diagnostic techniques, due to its high sensitivity and selectivity. Of special relevance is the incorporation of nanomaterials in biosensors, as they contribute to enhance electron transfer while promoting the immobilization of biological recognition elements. Moreover, nanomaterials have also been employed as labels, due to their unique electroactive and electrocatalytic properties. The aim of this review is to add value in the advances achieved in the detection of AD biomarkers, the strategies followed for the incorporation of nanomaterials and its effect in biosensors performance.

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“…This could be achieved by working with a manufacturer to plate a thicker layer of gold during the PCB production process, or through in house electroplating downstream of the PCB production. In addition to increasing the thickness of the gold layer on the surface of the electrode, gold nanoparticles could be explored in future work, by immobilising the DNA to the surface of the nanoparticles and using this in conjunction with a carbon electrode 27 .…”

Section: Use Of the Simplestat On Board Electrode To Detect Oxa-1mentioning

confidence: 99%