Applications of Light Emitting Diodes in Health Care

Dong, Jianfei; Xiong, Daxi

doi:10.1007/s10439-017-1930-5

Cited by 40 publications

(15 citation statements)

References 95 publications

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“…This type of waveguides can allow the watertight crosslinking between the tissues to be formed in situ; the waveguide need not to be removed from the site after the processing, as it is eventually biodegraded and absorbed by the tissue. Implantable waveguides can induce deep tissue stimulation by low-level light whose irradiance ranges from 5

to 5

[ 6 ] and offer new strategies for light sensing-based diagnostics, therapeutics and theranostics [ 33 , 34 ].…”

Section: Biocompatible Optical Waveguidesmentioning

confidence: 99%

“…Thus disease diagnosis, treatment and theranostics in macro and micro scales can be realized [ 1 ]. For instance, photodynamic therapy (PDT) for curing cancers [ 2 , 3 ], photothermal therapy (PTT) for tissue ablations [ 4 ], photobiomodulation (PBM) for cell proliferation and antimicrobial activities [ 5 , 6 ] have already been utilized in clinical medicine. Significantly, non-invasive physiological signal detections including but not limited to blood glucose, blood oxygen and analysis of chemicals in the body fluid have been successfully achieved [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

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Optical Waveguides and Integrated Optical Devices for Medical Diagnosis, Health Monitoring and Light Therapies

Wang

Dong

2020

Sensors

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Optical waveguides and integrated optical devices are promising solutions for many applications, such as medical diagnosis, health monitoring and light therapies. Despite the many existing reviews focusing on the materials that these devices are made from, a systematic review that relates these devices to the various materials, fabrication processes, sensing methods and medical applications is still seldom seen. This work is intended to link these multidisciplinary fields, and to provide a comprehensive review of the recent advances of these devices. Firstly, the optical and mechanical properties of optical waveguides based on glass, polymers and heterogeneous materials and fabricated via various processes are thoroughly discussed, together with their applications for medical purposes. Then, the fabrication processes and medical implementations of integrated passive and active optical devices with sensing modules are introduced, which can be used in many medical fields such as drug delivery and cardiovascular healthcare. Thirdly, wearable optical sensing devices based on light sensing methods such as colorimetry, fluorescence and luminescence are discussed. Additionally, the wearable optical devices for light therapies are introduced. The review concludes with a comprehensive summary of these optical devices, in terms of their forms, materials, light sources and applications.

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to 5

[ 6 ] and offer new strategies for light sensing-based diagnostics, therapeutics and theranostics [ 33 , 34 ].…”

Section: Biocompatible Optical Waveguidesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Optical Waveguides and Integrated Optical Devices for Medical Diagnosis, Health Monitoring and Light Therapies

Wang

Dong

2020

Sensors

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“…The LED light sources were designed following the procedures in [20], and were driven by a constant current source with PWM current level control to stabilize the output irradiance [21], [22]. The LED chips are arranged in either a 1.5cm-by-1.5cm square as a 4-by-4 array (385nm, 405nm and 415nm) or a 1cm-by-1cm square as a 3-by-3 array (450nm).…”

Section: A Led Light Source Designmentioning

confidence: 99%

Data Driven Modeling of the Reactive Oxygen Species Stimulated by Photon Energy in Light Therapies

Dong

Wang

2020

IEEE Access

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Light therapies can be used to treat fungal infections. A general mechanism is attributed to the generation of cytotoxic reactive oxygen species (ROS) due to light stimulation. The effectiveness of these therapies has been widely studied in the literature via conducting biological experiments, where fungi are exposed to light with various wavelengths and power. However, despite the large amount of work reporting the experimental results, few efforts have been given to build a mathematical model that describes the amount of generated ROS as a function of the photon energy and power of the stimulating light. The lack of such a model still hinders the optimization of the light doses. In this work, we propose a novel modeling method based on experimental data, so as to establish a mathematical relationship between the ROS concentration and the stimulating photon energy and light fluence (energy density). The anti-fungal experiments were performed on Candida albicans (C. albicans) using four LED light sources with different wavelengths ranging from 385nm to 450nm. Both the viability of the fungi and the ROS concentration therein were measured during the experiments. High fitting accuracy has been achieved by the model, which therefore demonstrates the effectiveness of the proposed modeling techniques. INDEX TERMS Biomedical engineering, data driven modeling, light-emitting diodes, light therapy, parameter estimation.

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“…Moreover, the current renaissance in gene therapy calls upon optogenetic approaches for patients with medical conditions that lack appropriate treatments, such as pharmacoresistant epilepsy [ 10 ] and inherited retinal degeneration [ 11 ]. High tissue penetration of the red and NIR light makes optogenetic approaches attractive for tissues where NIR light can be efficiently delivered by light emitting diodes (LED) [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Optogenetic regulation of transcription

et al. 2018

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Optogenetics has become widely recognized for its success in real-time control of brain neurons by utilizing non-mammalian photosensitive proteins to open or close membrane channels. Here we review a less well known type of optogenetic constructs that employs photosensitive proteins to transduce the signal to regulate gene transcription, and its possible use in medicine. One of the problems with existing gene therapies is that they could remain active indefinitely while not allowing regulated transgene production on demand. Optogenetic regulation of transcription (ORT) could potentially be used to regulate the production of a biological drug in situ, by repeatedly applying light to the tissue, and inducing expression of therapeutic transgenes when needed. Red and near infrared wavelengths, which are capable of penetration into tissues, have potential for therapeutic applications. Existing ORT systems are reviewed herein with these considerations in mind.

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Applications of Light Emitting Diodes in Health Care

Cited by 40 publications

References 95 publications

Optical Waveguides and Integrated Optical Devices for Medical Diagnosis, Health Monitoring and Light Therapies

Optical Waveguides and Integrated Optical Devices for Medical Diagnosis, Health Monitoring and Light Therapies

Data Driven Modeling of the Reactive Oxygen Species Stimulated by Photon Energy in Light Therapies

Optogenetic regulation of transcription

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