Applications of microcapillary films in bioanalytical techniques

Liu, Junfeng; Xu, Zhongbin; Shan, Yan Shen; Huang, Xing

doi:10.1039/d0an01945c

Cited by 8 publications

(2 citation statements)

References 70 publications

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“…Microcapillary films (MCFs) are plastic films containing an array of parallel microcapillaries with diameters in the range of 30-500 μm, [1] which have been widely applied as microfluidic platforms in droplet microfluidics and bioanalytical techniques. [2] MCFs were first fabricated by gas-assisted extrusion by Hallmark et al in 2005.…”

Section: Introductionmentioning

confidence: 99%

Precise Control of Microcapillary Size in Microcapillary Films by Liquid‐Assisted Extrusion

Liu

Zheng

et al. 2022

Macro Materials & Eng

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Microcapillary films (MCFs) are plastic films with an array of microcapillaries, which have been widely applied in microfluidics and bioanalytical techniques. However, the precise control of microcapillary size is still a problem hindering the industrial applications of MCFs because the high size uniformity of microcapillaries ensures the production of homogeneous droplets and the robust performance of immunoassays. Here, a novel approach is provided to precisely adjust the size of microcapillaries by liquid‐assisted extrusion and to investigate the combined effects of extrusion, drawing and liquid injection on the microcapillary size. Compared with gas‐assisted extrusion, the size uniformity is improved by at least 5% for 89% experiments and 10% for 42% experiments. Therefore, this method facilitates MCFs’ applications in droplet microfluidics and biotechnologies.

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Section: Introductionmentioning

confidence: 99%

Precise Control of Microcapillary Size in Microcapillary Films by Liquid‐Assisted Extrusion

Liu

Zheng

et al. 2022

Macro Materials & Eng

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“…Notably, MCF strips can be mass-produced at ≈50 pence m −1 via an extrusion process, [25] and the microcapillary diameter of the strips can be adjusted from 30 to 500 μm. [26] Therefore, MCFs are promising for microfluidics and industrial applications.…”

Section: Introductionmentioning

confidence: 99%

Improved Size Uniformity of Microcapillaries in Microcapillary Films by Separate Gas Injection

Liu

Zhao

et al. 2021

Macro Materials & Eng

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Microcapillary films (MCFs) are microextrusion-processed plastic films containing an array of parallel microcapillaries, and have been widely utilized as microfluidic platforms. However, the nonuniform size distribution within a single MCF strip limits the application of MCFs in monodisperse droplet generation. In this paper, the mechanisms that lead to uneven microcapillary dimensions in conventional MCFs whose gas pressures in all channels are the same is first clarified. The effect of gas pressure in a single channel on the microcapillary dimensions in the film is then studied. Finally, the size uniformity of the microcapillaries is improved by separate gas injection in different channels, providing new possibilities for the generation of highly monodisperse microdroplets.

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Enhanced scale-up performance on residence time distribution by integrated microcapillaries with high size uniformity

Liu,

Wang,

Zhao

et al. 2023

Chemical Engineering Journal

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Applications of microcapillary films in bioanalytical techniques

Abstract: This critical review focuses on the applications of microcapillary films (MCFs) in bioanalytical techniques.

Cited by 8 publications

References 70 publications

Precise Control of Microcapillary Size in Microcapillary Films by Liquid‐Assisted Extrusion

Precise Control of Microcapillary Size in Microcapillary Films by Liquid‐Assisted Extrusion

Improved Size Uniformity of Microcapillaries in Microcapillary Films by Separate Gas Injection

Enhanced scale-up performance on residence time distribution by integrated microcapillaries with high size uniformity

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