Applications of Modern Electroanalytical Techniques to Pharmaceutical Chemistry

Adams, Ralph N.

doi:10.1002/jps.2600581002

Cited by 62 publications

(6 citation statements)

References 35 publications

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“…More detailed quantitative treatments of forced convection voltammetry of compounds of interest in neuropharmacology are available (Adams, 1969b).…”

Section: Voltammetry and Current Measurements In Flowing Solutionmentioning

confidence: 99%

Electrochemical Detection Methods for Monoamine Measurements in Vitro and in Vivo

Adams

Marsden

1982

Handbook of Psychopharmacology

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“…More detailed quantitative treatments of forced convection voltammetry of compounds of interest in neuropharmacology are available (Adams, 1969b).…”

Section: Voltammetry and Current Measurements In Flowing Solutionmentioning

confidence: 99%

Electrochemical Detection Methods for Monoamine Measurements in Vitro and in Vivo

Adams

Marsden

1982

Handbook of Psychopharmacology

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“…Superoxide anion concentrations and CBF can thereby be measured at the same time in almost precisely the same tissue compartment, making it possible to relate CBF to superoxide anion levels. As is the case with most such electrochemical measurements, the current detected is the sum of the current produced by the species of anion of interest (i.e., superoxide anion) plus that produced by oxidation or reduction of other ions present (Adams, 1969). The electrode is not specific for superoxide anion (it also, for example, reacts with H 2 ), but, because of the cytochrome c coating and the applied potential chosen for these experiments, it is especially likely to react with superoxide anion to produce a current flow.…”

Section: Discussionmentioning

confidence: 99%

“…This was corrected for by subtracting a polarization factor, calculated as P ϭ B(1 Ϫ e Ϫk/t ), where P is the polarization factor, B is the baseline coefficient, k is the polarization coefficient, and t is the time from the onset of polarization. The polarization factor equation is based on longestablished electrochemical theory (Adams, 1969). The baseline was established by averaging the current from the first 100 min of the experiment, prior to the onset of ischemia, for each animal.…”

Section: Methodsmentioning

confidence: 99%

Electrochemical monitoring of superoxide anion production and cerebral blood flow: Effect of interleukin-1? pretreatment in a model of focal ischemia and reperfusion

2000

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Conditions associated with systemic infection, such as endotoxinemia, are known to increase the levels of pro‐inflammatory cytokines such as interleukin (IL)‐1 in the central nervous system. Systemic infection has been shown to be a common preexisting condition in patients with stroke. To examine a possible consequence of systemic infection, we used a novel electrochemical technique, which combines measurement of cerebral blood flow with measurement of superoxide anion concentrations, to examine the effect of pretreatment of pial vasculature with a proinflammatory cytokine, IL‐1β, on cerebral blood flow and superoxide anion concentration in a rat model of middle cerebral artery occlusion and reperfusion. In addition, neutrophil recruitment was measured using an immunohistochemical technique. Our results indicate that exposure of pial and cerebral vasculature to IL‐1β significantly accelerates recruitment of neutrophils, reduces cerebral blood flow, and increases superoxide anion concentration at the pial surface during reperfusion. These results support the idea that prior exposure of brain vasculature to IL‐1β results in acceleration of cerebrovascular injury by accelerating recruitment of neutrophils, which secrete superoxide anion, during reperfusion. This finding has possible implications for the treatment of stroke with reperfusion agents in patients with preexisting infections. J. Neurosci. Res. 60:795–803, 2000. © 2000 Wiley‐Liss, Inc.

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“…The detailed electrochemistry of these and similar species has been studied and the experimental approaches, applicable to a variety of pharmaceutical systems, have been reviewed (Adams, 1969).…”

Section: Basic In Vivo Electrochemical Experimentsmentioning

confidence: 99%

Directed Drug Delivery

Borchardt¹,

Repta²,

Stella³

1985

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All rights reservedNo part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording, or otherwise without written permission from the Publisher. PREFACEThis book is based on the proceedings of the symposium entitled "Directed Drug Delivery: A Multidisciplinary Problem," which was held in Lawrence, Kansas on October 17-19, 1984. The purpose of the symposium and this book is to focus on the multidisciplinary nature of drug delivery. Development of a successful drug delivery system requires contributions from various scientific disciplines, including pharmaceutical chemistry, analytical chemistry, medicinal chemistry, biochemistry, pharmacology, toxicology, and clinical medicine. The contents of this volume illustrate the importance of the various disciplines in identifying the problems and approaches for the development of a rational and effective drug delivery system. Thus the information provided herein will be of value not only to the pharmaceutical chemists who are responsible for dosage form design, but also to the pharmacokineticists, pharmacologists, and clinicians involved in biological evaluation of drug delivery systems. The volume should also be of interest to the analytical chemists who must provide technology to quantitcltively evaluate drug delivery. Additionally, this work will also interest the biochemists and medicinal chemists involved in drug discovery, since the drug delivery system often plays a major role in determining the success or failure of a new drug entity.Each speaker at the symposium was requested to contribute a chapter reviewing the contribution of their major discipline to the development of a successful drug delivery system. Topics covered in this volume include pharmacokinetics and pharmacodynamic factors (Section A) and physiological and biochemical factors (Section B) that influence directed drug delivery, various approaches to controlled and targeted drug delivery, including physical (SectionC) and biological (Section D) systems, as well as appropriate and important analytical chemistry topics (Section E).The individual chapters in this volume represent comprehensive, up-to-date reviews of the subject material. However, to gain maximum appreciation for the multidisciplinary nature of drug delivery, the editors suggest a thorough reading of the entire volume.

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Applications of Modern Electroanalytical Techniques to Pharmaceutical Chemistry

Cited by 62 publications

References 35 publications

Electrochemical Detection Methods for Monoamine Measurements in Vitro and in Vivo

Electrochemical Detection Methods for Monoamine Measurements in Vitro and in Vivo

Electrochemical monitoring of superoxide anion production and cerebral blood flow: Effect of interleukin-1? pretreatment in a model of focal ischemia and reperfusion

Directed Drug Delivery

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