Applications of molybdenum oxide nanoparticles impregnated collagen scaffolds in wound therapeutics

Indrakumar, Janani; Murali, Padmaja; Balan, Poornima; Solaimuthu, Anbuthiruselvan; Vijayan, Ane Nishitha; Korrapati, Purna Sai

doi:10.1016/j.jtemb.2022.126983

Cited by 8 publications

(6 citation statements)

References 31 publications

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“…In vivo studies highlighted a faster closure of wounds, attributed to the shortened duration of the inflammatory phase due to the presence of mupirocin, increased fibroblast proliferation, and subsequent enhanced collagen deposition. Moreover, Indrakumar et al, coupled collagen properties with those of molybdenum trioxide nanoparticles, known for their antibacterial and pro-angiogenic activities, to investigate their wound-healing potential [75]. Using in vivo wound models in Wistar rats, the composite scaffolds demonstrated a faster wound closure compared to the untreated controls.…”

Section: Counteracting Microbial Infectionsmentioning

confidence: 99%

Collagen-Based Scaffolds for Chronic Skin Wound Treatment

La Monica,

Campora,

Ghersi

2024

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Chronic wounds, commonly known as ulcers, represent a significant challenge to public health, impacting millions of individuals every year and imposing a significant financial burden on the global health system. Chronic wounds result from the interruption of the natural wound-healing process due to internal and/or external factors, resulting in slow or nonexistent recovery. Conventional medical approaches are often inadequate to deal with chronic wounds, necessitating the exploration of new methods to facilitate rapid and effective healing. In recent years, regenerative medicine and tissue engineering have emerged as promising avenues to encourage tissue regeneration. These approaches aim to achieve anatomical and functional restoration of the affected area through polymeric components, such as scaffolds or hydrogels. This review explores collagen-based biomaterials as potential therapeutic interventions for skin chronic wounds, specifically focusing on infective and diabetic ulcers. Hence, the different approaches described are classified on an action-mechanism basis. Understanding the issues preventing chronic wound healing and identifying effective therapeutic alternatives could indicate the best way to optimize therapeutic units and to promote more direct and efficient healing.

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Section: Counteracting Microbial Infectionsmentioning

confidence: 99%

Collagen-Based Scaffolds for Chronic Skin Wound Treatment

La Monica,

Campora,

Ghersi

2024

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“…This patent contains eleven claims outlining the process through which honey is included into dressings. It is effective for both acute and chronic wounds [ 111 ]. Michael Koganov et al (2013) patented “Bioactive compounds from theacea plants for wound and cut treatment” in 2013.…”

Section: Biopolymer-based Nanomaterials For Successful Wound Treatmentmentioning

confidence: 99%

A Comprehensive Review on Bio-Based Materials for Chronic Diabetic Wounds

et al. 2023

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Globally, millions of people suffer from poor wound healing, which is associated with higher mortality rates and higher healthcare costs. There are several factors that can complicate the healing process of wounds, including inadequate conditions for cell migration, proliferation, and angiogenesis, microbial infections, and prolonged inflammatory responses. Current therapeutic methods have not yet been able to resolve several primary problems; therefore, their effectiveness is limited. As a result of their remarkable properties, bio-based materials have been demonstrated to have a significant impact on wound healing in recent years. In the wound microenvironment, bio-based materials can stimulate numerous cellular and molecular processes that may enhance healing by inhibiting the growth of pathogens, preventing inflammation, and stimulating angiogenesis, potentially converting a non-healing environment to an appropriately healing one. The aim of this present review article is to provide an overview of the mechanisms underlying wound healing and its pathophysiology. The development of bio-based nanomaterials for chronic diabetic wounds as well as novel methodologies for stimulating wound healing mechanisms are also discussed.

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“…18 In particular, the molybdenum trioxide nanoparticles functionalized with methylene blue harnessed better intra/extracellular reactive oxygen species (ROS) production, 19 and the treatment of wounds with molybdenum trioxide particle-functionalized collagen scaffolds has shown an improved healing process. 20 Conversely, the surface-modified molybdenum trioxide nanoparticles have remarkable CAT-like activity and OXD-like activity in the acidic tumor microenvironment that inhibited tumor growth sparing normal cells. 21 These dynamic properties of molybdenum trioxide nanoparticles (MoO 3 NPs/MO NPs) position them as versatile tools in the field of regenerative medicine, with the potential to revolutionize approaches to tissue repair and regeneration.…”

Section: Introductionmentioning

confidence: 99%

“…Molybdenum nanoparticles hold the attributes of enhanced intracellular uptake, biocompatibility, improved function as nanozymes to mimic the native sulfite oxidase activity, and great potential for drug delivery . In particular, the molybdenum trioxide nanoparticles functionalized with methylene blue harnessed better intra/extracellular reactive oxygen species (ROS) production, and the treatment of wounds with molybdenum trioxide particle-functionalized collagen scaffolds has shown an improved healing process . Conversely, the surface-modified molybdenum trioxide nanoparticles have remarkable CAT-like activity and OXD-like activity in the acidic tumor microenvironment that inhibited tumor growth sparing normal cells .…”

Section: Introductionmentioning

confidence: 99%

Interaction of Multifunctional MoO₃ Nanoparticles with Dermal Fibroblasts for Treatment of Chronic Wounds

Murali,

Yananmala,

Indrakumar

et al. 2024

ACS Appl. Nano Mater.

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Effective therapies for skin wound healing and scar prevention are essential, and innovative approaches are necessary to address these clinical challenges. Due to their unique physicochemical properties, molybdenum trioxide nanoparticles (MoO 3 NPs) have emerged as promising candidates in wound healing and tissue repair. This study investigates the dose-responsive effects of MoO 3 NPs on dermal fibroblasts to provide insights into their potential applications in tissue repair and regeneration. Fibroblasts were exposed to a range of MoO 3 NP concentrations (from 50 to 400 μg/mL), and their cellular responses, including viability, proliferation, migration, and collagen synthesis, were assessed to comprehensively evaluate the influence of MoO 3 NPs on critical processes related to wound healing and fibrosis. Our findings reveal a dose-responsive relationship between MoO 3 NPs and skin fibroblast behavior; at lower concentrations (50 μg/mL), MoO 3 NPs exhibited stimulatory effects on fibroblast viability, proliferation, and migration, suggesting their potential as wound healing enhancers. Furthermore, this concentration stimulated the essential process of collagen synthesis, which plays a pivotal role in tissue repair. Nevertheless, with concentrations surpassing 50 μg/mL, a shift was noticeable as MoO 3 NPs started to impede cellular processes, particularly at high doses (400 μg/mL), resulting in decreased cell proliferation, migration, and angiogenesis. Also, the analysis of gene expression emphasized the regulatory influence of MoO 3 NPs on key genes associated with tissue repair and regeneration. Upregulation of transforming growth factor (TGF-β) and collagen genes was noted at lower concentrations, coinciding with improved healing responses, whereas higher doses downregulated these genes, potentially affecting fibroblast functionality. These findings emphasize the importance of precise nanoparticle dosing in therapeutic applications and provide valuable insights for the development of MoO 3 NP-based interventions to promote tissue repair.

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Applications of molybdenum oxide nanoparticles impregnated collagen scaffolds in wound therapeutics

Cited by 8 publications

References 31 publications

Collagen-Based Scaffolds for Chronic Skin Wound Treatment

Collagen-Based Scaffolds for Chronic Skin Wound Treatment

A Comprehensive Review on Bio-Based Materials for Chronic Diabetic Wounds

Interaction of Multifunctional MoO₃ Nanoparticles with Dermal Fibroblasts for Treatment of Chronic Wounds

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Applications of molybdenum oxide nanoparticles impregnated collagen scaffolds in wound therapeutics

Cited by 8 publications

References 31 publications

Collagen-Based Scaffolds for Chronic Skin Wound Treatment

Collagen-Based Scaffolds for Chronic Skin Wound Treatment

A Comprehensive Review on Bio-Based Materials for Chronic Diabetic Wounds

Interaction of Multifunctional MoO3 Nanoparticles with Dermal Fibroblasts for Treatment of Chronic Wounds

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Product

Resources

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Interaction of Multifunctional MoO₃ Nanoparticles with Dermal Fibroblasts for Treatment of Chronic Wounds