Applications of neurophysiological methods in occupational medicine. A review.

Am, Seppäläinen

doi:10.5271/sjweh.2865

Cited by 43 publications

(10 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The earliest subjective symptoms of neuropathy caused by long-term low level exposure to organic solvents are sensory; they appear -in agreement with the distribution of the pathological-anatomical changes -in the distal parts of the limbs, beginning in the feet (70,73). In agreement we found the most significant (p < 0.001) differences between the exposed group and the referents in the function of the purely sensory sural nerve distally on the lower leg.…”

Section: Electroneurographysupporting

confidence: 76%

Exposure to organic solvents. A cross-sectional epidemiologic investigation on occupationally exposed care and industrial spray painters with special reference to the nervous system.

Elofsson¹,

Gamberale²,

Hindmarsh³

et al. 1980

Scand J Work Environ Health

249

View full text Add to dashboard Cite

Section: Electroneurographysupporting

confidence: 76%

Exposure to organic solvents. A cross-sectional epidemiologic investigation on occupationally exposed care and industrial spray painters with special reference to the nervous system.

Elofsson¹,

Gamberale²,

Hindmarsh³

et al. 1980

Scand J Work Environ Health

249

View full text Add to dashboard Cite

“…Therefore, clinical symptoms were usually first seen in distal parts of the extremities. This type of neuropathy is also seen in other genetic and acquired neuropathies, ie, in connection with exposure to lead, vibration, and alcohol (16,17). A slow recovery has been seen after the cessation of arsenic exposure (4,5,9,11).…”

mentioning

confidence: 85%

Arsenic exposure to smelter workers. Clinical and neurophysiological studies.

Blom¹,

Lagerkvist²,

Linderholm³

1985

Scand J Work Environ Health

View full text Add to dashboard Cite

BLOM S, LAGERKVIST B, LINDERHOLM H . Arsenic exposure to smelter workers: Clinical and neurophysiological studies . Scand J Work Environ Health II (1985) 265-269. Forty-se ven copper smelter workers, exposed to airborne ar senic for 8-40 years, were examined clinically with electromyography, and the motor and sensory conduction velocities in their arm s and legs were determined. Fifty age-matched industrial workers not exposed to arsenic formed a reference group. The level of arsenic in the air at the smeltery was estimated to be below 500 J.lg/m J before 1975 and approximately 50 J.lg/m J thereafter. Urine analyses of arsenic showed a mean value of 71 J.lg/I (I J.lmolll) in the exposed group; this value is lower than that found in earlier studies reporting clinically detectable neuropathy. Only minor neurological and eiectromyographic abnormalities were found. A slightly reduced nerve conduction velocity in two or more peripheral nerves was more common among the arsenic workers than the referents, and a statistically significant correlation between cumulative exposure to arsenic and reduced nerve conduction velocity in three peripheral motor nerves was found. This occurrence was interpreted as a sign of slight subclinical neuropathy. In conclusion the risk of clinically significant neuropathy is small when exposure is kept below 50 J.lg/m J in workroom air. The subclinical findings may be of interest in relation to the prevention of early adverse health effects from arsenic exposure.

show abstract

“…Neurophysiological methods have proved sensitive in showing the neurotoxic effects of several industrial chemicals (8,34). We decided to apply these methods in our study, which was focused on car painters exposed to a mixture of organic solvents.…”

mentioning

confidence: 99%

Neurophysiological effects of long-term exposure to a mixture of organic solvents.

Seppäläinen¹,

Husman²,

Martenson³

1978

Scand J Work Environ Health

Self Cite

View full text Add to dashboard Cite

effects of long-term exposure to a mixture of organic solvents. Scand. j. work environ. & health 4 (1978) [304][305][306][307][308][309][310][311][312][313][314]. Neurophysiological effects of long-term exposure to a mixture of organic solvents was studied among 102 car painters from 27 car repair garages in Helsinki. The reference group consisted of 102 age-matched railroad engineers from the Finnish State Railways. The mean age was 35 years and the exposure time ranged from 1 to 40 years (mean 14.8, SD 8.5). According to measurements the mean concentration of the solvent mixture was relatively low in the garages, namely, 31.8 % of the Finnish threshold limit value (TLV), the range of separate components varying from 4 to 212 % of the respective TLVs. The main components of about 20 organic solvents of the mixture were toluene, xylene, butyl acetate and white spirit. Electroencephalograms (EEGs) of all the 102 exposed and 102 nonexposed subjects were studied, but electroneuromyographic measurements were made of only 59 car painters and 53 referents with a similar age distribution. Motor (MCV and CVSF) and sensory conduction (SCV) velocities, as well as motor distal latencies, were recorded from nerves in the upper and lower extremities. Abnormal EEGs were encountered in 32 car painters and 37 referents. The frequency of abnormal EEGs was in both groups higher than expected on the basis of EEG literature (about 10 0 /0). Twenty-six car painters had a complex of four common symptoms of disturbances in the central nervous system; the same symptom complex was found in 12 engineers. Forty-six percent of the car painters with this symptom complex had an abnormal EEG, while only 26 Ofo of those without this symptom complex had an abnormal EEG. Railroad engineers did not show such a tendency. Abnormally slow MCVs or SCVs and/or prolonged motor distal latencies were found in 12 of the 59 car painters but in none of the 53 engineers studied. Other authors have stressed that many solvents primarily cause neuropathy, while objective signs of central nervous involvement have been minor, if any. Our findings are similar; they showed slight positive signs of slowed nerve conduction velocities among the car painters and no increase in EEG abnormalities in comparison to the reference group of railroad engineers.

show abstract

Applications of neurophysiological methods in occupational medicine. A review.

Cited by 43 publications

References 34 publications

Exposure to organic solvents. A cross-sectional epidemiologic investigation on occupationally exposed care and industrial spray painters with special reference to the nervous system.

Exposure to organic solvents. A cross-sectional epidemiologic investigation on occupationally exposed care and industrial spray painters with special reference to the nervous system.

Arsenic exposure to smelter workers. Clinical and neurophysiological studies.

Neurophysiological effects of long-term exposure to a mixture of organic solvents.

Contact Info

Product

Resources

About