Applications of Serum Protein Electrophoresis in Exotic Pet Medicine

Melillo, Alessandro

doi:10.1016/j.cvex.2012.11.002

Cited by 55 publications

(32 citation statements)

References 22 publications

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“…Although normal values (reference intervals) for peritoneal fluid in striped skunks are not established, these results were compatible with increased g-globulin levels compared with normal serum values in ferrets, 7 suggesting either exudation or localized antibody (immunoglobulin) production. Results of the other ancillary diagnostic tests are shown in the Supplemental Materials.…”

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confidence: 61%

Aleutian Disease

et al. 2014

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Aleutian disease virus (ADV, Amdovirus, Parvoviridae) primarily infects farmed mustelids (mink and ferrets) but also other fur-bearing animals and humans. Three Aleutian disease (AD) cases have been described in captive striped skunks; however, little is known about the relevance of AD in free-ranging carnivores. This work describes the pathological findings and temporospatial distribution in 7 cases of AD in free-ranging striped skunks. All cases showed neurologic disease and were found in a 46-month period (2010-2013) within a localized geographical region in California. Lesions included multisystemic plasmacytic and lymphocytic inflammation (ie, interstitial nephritis, myocarditis, hepatitis, meningoencephalitis, pneumonia, and splenitis), glomerulonephritis, arteritis with or without fibrinoid necrosis in several organs (ie, kidney, heart, brain, and spleen), splenomegaly, ascites/hydrothorax, and/or encephalomalacia with cerebral microangiopathy. ADV infection was confirmed in all cases by specific polymerase chain reaction and/or in situ hybridization. The results suggest that AD is an emerging disease in free-ranging striped skunks in California.

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confidence: 61%

Aleutian Disease

et al. 2014

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“…Serum proteins are mainly synthesized in the liver, and, among other functions, maintain blood volume through the colloidal osmotic effect, buffer blood pH, transport hormones and drugs, participate in cell coagulation, catalyze chemical reactions (enzymes), regulate the metabolism (hormones), and participate in the body defense against foreign agents (Melillo, 2013).…”

Section: Serum Biochemical Parametersmentioning

confidence: 99%

“…Ross et al (1978) determined albumin values of 10.80-16.10 g/L in broilers, whereas Barbosa et al (2011) found 11.40-12.10 g/L in commercial layers during lay. The main functions of albumin are the transport of several molecules and the maintenance of blood oncotic pressure (Melillo, 2013).…”

Section: Serum Biochemical Parametersmentioning

confidence: 99%

Profile of Serum Metabolites and Proteins of Broiler Breeders in Rearing Age

Rezende

Mundim

Fonseca

et al. 2017

Rev. Bras. Cienc. Avic.

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The excellence of modern broiler production is based on the genetic improvement of broiler strains for high growth rate and high egg production, associated with technological developments in nutrition, management, and health. Over the last decades, the clinical biochemistry of broilers has been studied to determine serum biochemical component values; however, there are still many knowledge gaps on factors that determine changes in these values. In this study, the serum lipid and protein profiles of 4-week-old male and female Cobb broiler breeders were evaluated. Blood samples were collected on a commercial farm located in the city of Uberlândia, MG, Brazil. The following parameters were evaluated: total protein, albumin, globulin, albumin to globulin ratio (A/V), uric acid, urea, cholesterol, and triglyceride levels using an automatic analyzer. The results showed sex-specific biochemical patterns for most blood parameters evaluated. Moreover, the obtained values were different from those obtained in many published studies with broilers and commercial layers, stressing the need to develop further studies with chickens of different ages.

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“…Distinct alterations in globulin percentages vary among species and inflammatory or disease conditions, presenting some ongoing challenges with the application of this technique in exotic species. 4 This lack of change over time supports absence of a notable acute phase inflammatory response in these animals. However, if the APR in teleost fish is primarily localized, which has been suggested by other researchers, 7 a concurrent decrease in systemic concentrations of globulin proteins may occur as they are redirected or sequestered into the area of local inflammation.…”

Section: Discussionmentioning

confidence: 78%

“…1,2 Electrophoresis has been extensively investigated in domestic mammals and birds as both a diagnostic tool and a prognostic indicator, but small sample sizes and lack of intensive research have resulted in limited clinical application in other species, including fish. 3,4 Individual acute phase proteins (APPs) have been identified within the large protein fractions and may provide a more specific picture of the inflammatory response and recovery process in various species. Proteins homologous to those characterized in mammals have been identified in fish species and are presumed to perform a similar function.…”

mentioning

confidence: 99%