2008
DOI: 10.1016/j.addr.2006.12.001
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Applications of supercritical CO2 in the fabrication of polymer systems for drug delivery and tissue engineering

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Cited by 263 publications
(174 citation statements)
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“…This rather long soaking time is most probably due to the high crystallinity of PCL10 (around 52% by DSC). It is well known that CO 2 is able to diffuse and dissolve only in the amorphous regions of polymers [5,18,58], and that the T m depression is given by both polymer-CO 2 interactions in the amorphous regions and crystallites characteristics (e.g. lamellar thickness and heat of fusion per unit of volume); hence, different effects will be expected for different levels of amorphous fractions [18,58].…”
Section: Effect Of Pressure On T M Of Pcl10mentioning
confidence: 99%
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“…This rather long soaking time is most probably due to the high crystallinity of PCL10 (around 52% by DSC). It is well known that CO 2 is able to diffuse and dissolve only in the amorphous regions of polymers [5,18,58], and that the T m depression is given by both polymer-CO 2 interactions in the amorphous regions and crystallites characteristics (e.g. lamellar thickness and heat of fusion per unit of volume); hence, different effects will be expected for different levels of amorphous fractions [18,58].…”
Section: Effect Of Pressure On T M Of Pcl10mentioning
confidence: 99%
“…In recent years there has been increasing interest in the use of high-pressure CO 2 as a reaction medium or plasticiser for polymer synthesis and processing [1][2][3][4][5][6]. CO 2 has been exploited as a solvent for polymerisations [7,8], as a foaming agent [1,[9][10][11][12][13], for precipitation/separation [14], particle formation [15,16] and encapsulation [17].…”
Section: Introductionmentioning
confidence: 99%
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“…PCL is a biodegradable aliphatic polyester that is being commonly used for biomedical applications due to its biocompatibility and biodegradability, mainly for the preparation of drug delivery devices and tissue engineering scaffolds [3][4][5]. Therefore, the processing of PCL with scCO 2 has been widely analyzed, starting from the basic research on the thermodynamic and mass transport properties of the specific binary system [6,7].…”
Section: Introductionmentioning
confidence: 99%
“…13 CO 2 supercritical fluid is the best choice, from among the others available for pharmaceutical processes, as it is affordable, nontoxic, and inflammable. Further, it has high volatility, mild critical temperature (304°K), low critical pressure (7.38 MPa), low cohesive energy density, low polarizability per unit volume, and poor solubility for many polymers and drugs, 8,10,13,15,16 and it has low viscosity like a gas, although its density is similar to that of a liquid. Around the critical point, its properties such as density, viscosity, solvency, and diffusivity can be manipulated by adjusting the pressure and temperature.…”
Section: Introductionmentioning
confidence: 99%