Applied Logistic Regression

Hosmer, David W.; Lemeshow, Stanley

doi:10.1002/0471722146

Cited by 19,261 publications

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“…Multiple logistic regression (25) was performed in the largest ethnic subset to test the effect of the presence of an affected male relative on the probability of having renal disease, adjusting for disease duration and age at onset of SLE. Because our analysis included related individuals and the observations were therefore correlated, the multiple logistic regression was embedded in a generalized estimating equation (GEE) framework (26) to account for correlations within families.…”

Section: Methodsmentioning

confidence: 99%

Increased prevalence of renal disease in systemic lupus erythematosus families with affected male relatives

Stein

Olson

Gray‐McGuire

et al. 2002

Arthritis & Rheumatism

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Objective. To distinguish familial differences from sex-related differences in the clinical manifestations of systemic lupus erythematosus (SLE).Methods. A total of 372 affected individuals from 160 multiplex SLE pedigrees were analyzed. Twenty-five of these pedigrees contained at least 1 affected male relative. Comparisons of the presence of each of the 11 1982 American College of Rheumatology criteria for SLE were made between female family members with affected male relatives and those without affected male relatives, using Fisher's exact tests.Results. The presence of renal disease was significantly increased in female family members with an affected male relative when compared with those with no affected male relative (68% and 43%, respectively; P ‫؍‬ 0.002). This trend remained after stratifying by race and was most pronounced in European Americans. A familial basis for differences in hematologic and immunologic manifestations was also suggested, while arthritis and dermatologic features appeared to be most influenced by sex.Conclusion. Our results demonstrate that the increased prevalence of renal disease previously reported in men with SLE is, in large part, a familial rather than sex-based difference, at least in multiplex SLE families. Distinguishing familial from sex-related differences may facilitate efforts to understand the genetic and hormonal factors that underlie this complex autoimmune disease.

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Section: Methodsmentioning

confidence: 99%

Increased prevalence of renal disease in systemic lupus erythematosus families with affected male relatives

Stein

Olson

Gray‐McGuire

et al. 2002

Arthritis & Rheumatism

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“…Discrimination and calibration of the logistic regression models were assessed with the c-index and HosmerLemeshow goodness-of-fit (HL) statistic, respectively (34). The c-index is the percentage of comparisons where sexually active (or sexually impaired) patients had a higher predicted probability of being sexually active (or sexually impaired) than inactive patients (or nonimpaired patients), for all possible pairs of active and inactive patients (or impaired and nonimpaired patients).…”

Section: Statistical Analysesmentioning

confidence: 99%

Rates and correlates of sexual activity and impairment among women with systemic sclerosis

Levis

Hudson

Knafo

et al. 2012

Arthritis Care & Research

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Objective. To assess 1) the rates of sexual activity and impairment, 2) clinical correlates of sexual activity/impairment, and 3) common sources of pain during and after sex in a large sample of female patients with systemic sclerosis (SSc; scleroderma). Methods. We performed a cross-sectional multicenter study of female SSc patients from the Canadian Scleroderma Research Group Registry. Patients underwent medical examinations and clinical histories and were asked whether they had engaged in sexual activities with their partner in the past 4 weeks. Sexually active patients completed a 9-item version of the Female Sexual Function Index (FSFI) and items related to problems that may be linked to sexual dysfunction in SSc. Multivariate logistic regressions assessed independent predictors of activity/inactivity and sexual dysfunction. Results. A total of 226 (41%) of 547 patients, including 215 (54%) of the 401 patients currently in relationships, reported having engaged in sexual activities with a partner in the past 4 weeks. Among 165 sexually active patients with complete data for all variables, 102 (62%) had FSFI total scores <22.5, indicating impaired function. Seventeen percent of the patients were sexually active and not impaired. Independent predictors (P < 0.05) of sexual activity were younger age, fewer gastrointestinal symptoms, and less severe Raynaud's phenomenon symptoms. Sexual impairment was independently associated with older age, higher skin scores, and more severe breathing problems. Vaginal pain was 8 times more likely among women with impairment. Conclusion.Research is needed to compare the extent of activity and impairment in SSc compared to women without SSc and to develop interventions to address impaired sexual function in women with SSc.

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“…Multivariable binary and multinomial logistic regression analyses were used, as appropriate to the number of levels of the response variables, to examine associations of antisocial syndromes with clinical characteristics of DUDs, adjusted for the potentially confounding effects of age, sex, marital status, education, past-year income, region, urbanicity, family history of drug problems, and comorbid Axis I and II psychiatric diagnoses (Hosmer and Lemeshow, 2000). The referent category of antisocial syndrome was the group with no antisocial syndrome in either childhood or adulthood.…”

Section: Statistical Analysesmentioning

confidence: 99%

Antisocial behavioral syndromes and DSM-IV drug use disorders in the United States: Results from the National Epidemiologic Survey on Alcohol and Related Conditions

Goldstein

Compton

Pulay

et al. 2007

Drug and Alcohol Dependence

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Background-Antisocial behavioral syndromes, including antisocial personality disorder (ASPD), syndromal adult antisocial behavior (AABS) without conduct disorder (CD) before age 15, and CD without progression to ASPD ("CD only") are highly comorbid with drug use disorders (DUDs). Among patients in DUD treatment, antisocial syndromes are associated with greater severity and poorer outcomes. Comparative data concerning associations of antisocial syndromes with clinical characteristics of DUDs among general population adults have not previously been available. This study describes associations of antisocial syndromes with clinical characteristics of lifetime Diagnostic and Statistical Manual -Version IV DUDs in the general U.S. adult population. Methods-This report is based on the 2001-2002 National Epidemiologic Survey on Alcohol andRelated Conditions (n=43,093, response rate=81%). Respondents (n=4,068) with lifetime DUDs were classified according to whether they met criteria for ASPD, AABS, "CD only," or no antisocial syndrome. Associations of antisocial syndromes with clinical characteristics of DUDs were examined using logistic regression.Results-Antisocial syndromes were significantly associated with the phenomenology of DUDs, particularly ASPD with the most severe clinical presentations. Associations with AABS were similar to those with ASPD; those with "CD only" were weak, inconsistent, and not statistically significant. Patterns of associations differed little between men and women.

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Applied Logistic Regression

Cited by 19,261 publications

References 0 publications

Increased prevalence of renal disease in systemic lupus erythematosus families with affected male relatives

Increased prevalence of renal disease in systemic lupus erythematosus families with affected male relatives

Rates and correlates of sexual activity and impairment among women with systemic sclerosis

Antisocial behavioral syndromes and DSM-IV drug use disorders in the United States: Results from the National Epidemiologic Survey on Alcohol and Related Conditions

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