This paper gives substantiations to a system of effective engineering support of crop cultivation for improving competitiveness of produced goods. Considering the modernization of plant cultivation techniques and technical facilities to carry out agricultural practices, the optimal system of machines for mechanizing crop cultivation was proposed. In substantiating the system of machines, the method of analysis and synthesis of existing and proposed agricultural practices with their engineering support, the methods of modeling and optimization of production processes were proposed to determine the parameters and operating modes of the proposed machines in the system, the planning of a multifactorial experiment according to the BК-plan was used. As a result of the research, the original engineering support system of crop cultivation for lowland agricultural landscapes is proposed, which, according to calculations conducted, allows increasing labor productivity by at least a factor of two. It became possible due to modernization of tillage processes, sowing and harvesting, by combining separate previously technological operations in multifunctional units. The modernization of machine-tractor units was accomplished using original devices for serial machines according to the inventions of the authors. The proposed multifunctional units without a break in time, in a single stream and pace carry out production processes that coincide in calendar terms in the technology of a cultivated agricultural crop, contributing to the quality of work and higher yields.