Abstract-Automated and accurate classification of magnetic resonance (MR) brain images is a hot topic in the field of neuroimaging. Recently many different and innovative methods have been proposed to improve upon this technology. In this study, we presented a hybrid method based on forward neural network (FNN) to classify an MR brain image as normal or abnormal. The method first employed a discrete wavelet transform to extract features from images, and then applied the technique of principle component analysis (PCA) to reduce the size of the features. The reduced features were sent to an FNN, of which the parameters were optimized via an improved artificial bee colony (ABC) algorithm based on both fitness scaling and chaotic theory. We referred to the improved algorithm as scaled chaotic artificial bee colony (SCABC). Moreover, the K-fold stratified cross validation was employed to avoid overfitting. In the experiment, we applied the proposed method on the data set of T2-weighted MRI images consisting of 66 brain images (18 normal and 48 abnormal). The proposed SCABC was compared with traditional training methods such as BP, momentum BP, genetic algorithm, elite genetic algorithm with migration, simulated annealing, and ABC. Each algorithm was run 20 times to reduce randomness. The results show that our SCABC can obtain the least mean MSE and 100% classification accuracy.