Appraisal of Comparative Therapeutic Potential of Undoped and Nitrogen-Doped Titanium Dioxide Nanoparticles

Abstract

Nitrogen-doped and undoped titanium dioxide nanoparticles were successfully fabricated by simple chemical method and characterized using x-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive x-ray (EDX), and transmission electron microscopy (TEM) techniques. The reduction in crystalline size of TiO2 nanoparticles (from 20–25 nm to 10–15 nm) was observed by TEM after doping with N. Antibacterial, antifungal, antioxidant, antidiabetic, protein kinase inhibition and cytotoxic properties were assessed in vitro to compare the therapeutic potential of both kinds of TiO2 nanoparticles. All biological activities depicted significant enhancement as a result of addition of N as doping agent to TiO2 nanoparticles. Klebsiella pneumoniae has been illuminated to be the most susceptible bacterial strain out of various Gram-positive and Gram-negative isolates of bacteria used in this study. Good fungicidal activity has been revealed against Aspergillus flavus. 38.2% of antidiabetic activity and 80% of cytotoxicity has been elucidated by N-doped TiO2 nanoparticles towards alpha-amylase enzyme and Artemia salina (brine shrimps), respectively. Moreover, notable protein kinase inhibition against Streptomyces and antioxidant effect including reducing power and % inhibition of DPPH has been demonstrated. This investigation unveils the more effective nature of N-doped TiO2 nanoparticles in comparison to undoped TiO2 nanoparticles indicated by various biological tests. Hence, N-doped TiO2 nanoparticles have more potential to be employed in biomedicine for the cure of numerous infections.

Acesulfame K Photodegradation over Nitrogen-Doped TiO2

“…N-doped TiO2 powder XRD results were found to be strongly dependent on the nitrogen precursor. In the case of ammonia (as in this study) [19], ammonium nitrate [20], and nitric acid [21] as nitrogen precursors, no visible changes in the TiO2 crystal structure were observed; i.e., the N-doped TiO2 crystalline phase was determined by the synthesis conditions (mainly the calcination temperature, which determines the share of anatase and rutile phases), as in the case of undoped TiO2. As a result, no significant differences between N-doped and undoped TiO2 can be seen in the XRD patterns.…”

Diverse biotechnological applications of multifunctional titanium dioxide nanoparticles: An up‐to‐date review

“…One of the main contributing factors in antibiotic resistance is the formation of biofilms [42]. Therefore, research is shifted to the exploration of antimicrobial potential of metal and metal oxide NPs [43]. Because of their photocatalytic nature and the fact that they are chemically stable, non-toxic, affordable, and Generally Recognised as Safe, TiO 2 NPs have been regarded as an appealing antimicrobial agents [44].…”

Perspectives on plasma-assisted synthesis of N-doped nanoparticles as nanopesticides for pest control in crops

“…130,131 Besides, it has been demonstrated that modifying the surface of nanoparticles by nitrogen doping could improve photocatalytic properties, which leads to the enhancement of antifungal and antibacterial characteristic, compared to original nanoparticles. 132,133 Although there are only a few studies of nitrogen-doped nanoparticles on pest control, their applications are expected to be promising for green agriculture. Therefore, we will summarize their current use in controlling phytopathogens, and prove the impact of nitrogen doping on pesticide activity.…”