Appraisal of GFR-Estimating Equations Following Kidney Donation

Sebasky, Meghan; Kukla, Aleksandra; Leister, Erin; Guo, Hongbo; Akkina, Sanjeev; Elshahawy, Yasser; Matas, Arthur J.; Ibrahim, Hassan N.

doi:10.1053/j.ajkd.2009.01.264

Cited by 19 publications

(18 citation statements)

References 20 publications

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“…Long-term observation of transplant kidney donors suggested that the remaining kidney would compensate adequately. 8 However, renal cancer patients are typically older than the average living transplant donor. They also have underlying chronic illnesses and an increased rate of CKD, and they are less able to accommodate removal of one kidney.…”

Section: Radical Nephrectomy Is Too Radicalmentioning

confidence: 99%

The Importance of Nephron-Sparing Focal Therapy: Renal Function Preservation

Lucas¹,

Cadeddu²

2010

Journal of Endourology

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Historically, renal cancer has been treated with radical nephrectomy. Consequently, many patients developed renal insufficiency and the health problems associated with this. With the increasing diagnosis of small renal masses, nephron-sparing treatments have been developed to treat these masses adequately, while maximizing renal function. Focal ablative therapy is a means to treat small renal masses in a minimally invasive manner. Yet, there are few studies that have focused on their ability to preserve renal function. In this article, we review the existing literature on the renal function outcomes of patients treated with either radio frequency ablation or cryoablation.

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Section: Radical Nephrectomy Is Too Radicalmentioning

confidence: 99%

The Importance of Nephron-Sparing Focal Therapy: Renal Function Preservation

Lucas¹,

Cadeddu²

2010

Journal of Endourology

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“…reported on the performance of these equations in a large cohort of living kidney donors who underwent formal iohexol glomerular filtration rate (mGFR) measurement and found that the re-expressed Modification of Diet in Renal Disease (MDRD) equation could be a reasonable substitute, albeit still suboptimal and is clearly inferior to formal GFR measurements (7,8).…”

mentioning

confidence: 99%

Comparison of Cystatin C and Creatinine-Based Equations for GFR Estimation After Living Kidney Donation

Issa¹,

Kukla

Jackson

et al. 2014

Transplantation

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“…Watnick (13) found the mean GFR of 66 ml/min per 1.73 m 2 measured by inulin clearance in 29 donors with similar ages and intervals after donation to our Caucasian donor group. In a more recently published study from Minnesota, a subgroup of subjects had GFR measured by plasma disappearance of iohexol (16). Compared with donors in this series, our control group of Caucasian donors had higher measured GFR (78.2 ml/min versus 71.8 ml/min), although the interval from donation was very similar (12 Ϯ 4 years for our series versus 12 Ϯ 9 years for Minnesota donors).…”

Section: Discussionmentioning

confidence: 47%

“…Self-reported prevalence of HTN in Caucasian donors was 24.7% (16). Our study indicates that HTN, although more prevalent in the AA than Caucasian general population with two kidneys, is less prevalent in AAs than Caucasians with 50% reduction in kidney mass.…”

Section: Discussionmentioning

confidence: 52%

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Long-Term Effects of Kidney Donation on Renal Function and Blood Pressure in African Americans

Budisavljevic

Nietert

Zhai

et al. 2011

Clinical Journal of the American Society of Nephrology

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SummaryBackground and objectives African Americans (AAs) have four times higher prevalence of ESRD than Caucasians. Therefore, long-term effects of kidney donation are of considerable importance in this patient population.Design, setting, participants, & measurements GFR was measured by 125 I-iothalamate clearance, 24-hour urine albumin excretion, and 24-hour BP monitoring in 33 AAs and 11 CAs who donated kidneys for transplantation 5 to 23 years previously.Results Mean GFRs were 76 Ϯ 13 and 78 Ϯ 11 ml/min per 1.73 m 2 for AA and CA donors, respectively. Nine percent of the AA donors and none of the CA donors had GFRs below 60 ml/min per 1.73 m 2 . AA donors had a tendency for lower prevalence of microalbuminuria compared with CA donors (18.1% versus 36.3%) and a tendency for higher prevalence of macroalbuminuria compared with CAs (12.1% versus 0.0%). Twenty-four percent of the AAs, and 45% of the CAs were hypertensive with mean daytime BP Ն135/85 mmHg. Only 6% of AAs had a decrease in mean nocturnal systolic BP of 10% or more as compared with daytime readings. Older age at time of donation was associated (P ϭ 0.046) with lower GFR values compared with younger ages. ConclusionCarefully selected AA kidney donors have well preserved renal function and a low prevalence of hypertension many years after kidney donation. Abnormal albumin excretion and loss of physiologic decrease in nocturnal BP is more prevalent in AA donors than the general AA population. Older age at donation may predict lower GFR after donation.

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Appraisal of GFR-Estimating Equations Following Kidney Donation

Abstract: Background-It is not clear which serum creatinine-based glomerular filtration rate (GFR) estimating model performs best in kidney donors.

Cited by 19 publications

References 20 publications

The Importance of Nephron-Sparing Focal Therapy: Renal Function Preservation

The Importance of Nephron-Sparing Focal Therapy: Renal Function Preservation

Comparison of Cystatin C and Creatinine-Based Equations for GFR Estimation After Living Kidney Donation

Long-Term Effects of Kidney Donation on Renal Function and Blood Pressure in African Americans

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