Appraisal of the Real-World Effectiveness of Biologic Therapies in Aspirin-Exacerbated Respiratory Disease

Successful simultaneous targeting of IgE and IL-5 in a severe asthmatic patient selected for lung transplantation

“…Although dual biologic therapy is not uncommon in severe asthma, it is rare. 6 In AERD, many patients try many different biologics 7,8 as is the case in this report.…”

Advances in chronic rhinosinusitis in 2020 and 2021

“…151 Also dupilumab 152 and omalizumab 153 demonstrated a beneficial effect in patients with AERD. In a first real-life retrospective comparison on 74 patients between dupilumab, omalizumab, mepolizumab, benralizumab, and reslizumab, Wangberg et al 154 showed that anti-IL-4Ra therapy led to significantly higher rates of clinical improvement in AERD when compared with anti-IL-5/IL-5Ra and anti-IgE in terms of reduction of SNOT-22, corticosteroid bursts, and antibiotic courses for respiratory disease.…”

The Role of Omalizumab in NSAID-Exacerbated Respiratory Disease: A Narrative Review

“…47,48 Moreover, antieIL-5 treatment may not affect aspirin-induced symptoms in N-ERD. 49,50 Therefore, eosinophils, although important, may not play a central role in the pathogenesis of N-ERD.…”