Appraisal of the Toxicity of Sunscreen Preparations

Draize, John H.

doi:10.1001/archderm.1951.01570110055008

Cited by 5 publications

(2 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Draize scoring, developed by John Draize (1951), provides a method of grossly assessing the degree of inflammation based on quantifying the values that are at risk of interpretation bias or being considered insignificant. Originally developed for use in rabbits, it has been modified for use in both swine and humans and thus is often referred to as the modified Draize score.…”

Section: Clinical Evaluation Of Topical Reactionsmentioning

confidence: 99%

The Miniature Swine as a Model in Experimental and Translational Medicine

2016

View full text Add to dashboard Cite

The use of the miniature swine as a nonrodent species in research has continued to expand for over a decade, and they are becoming routinely used both in experimental pharmacology and as a therapeutic model for human diseases. Miniature swine models are regularly used for studies designed to assess efficacy and safety of new therapeutic compounds given through different routes of exposure and are used as an alternative model to rodents, canines, or nonhuman primates. Translational preclinical swine study data presented here support the current understanding that miniature swine are the animal model of choice for the assessment of drugs targeting endocrine, dermal, and ocular disorders. Because research investigators need to be familiar with some of the important features of the models developed in the miniature swine in order to place clinical and experimental findings in their proper perspective, relevant references and data from these models will be presented, compared, and partially illustrated.

show abstract

Section: Clinical Evaluation Of Topical Reactionsmentioning

confidence: 99%

The Miniature Swine as a Model in Experimental and Translational Medicine

2016

View full text Add to dashboard Cite

show abstract

“…Topical Anti-inflammatory Activity-This was evaluated by a modification of the rabbit skin irritation test of Draize (13). Irritation was induced with sodium lauryl sulfate using a ratio of test material to sodium lauryl sulfate of 5 :20 (mg./ml.).…”

Section: Pharmacological Testsmentioning

confidence: 99%