In this paper, by using the classical compression-expansion fixed point
theorem of Krasnoselskii, we study the existence and nonexistence of
monotone and convex positive solutions for a nonlinear fifth-order
differential equation with multi-point and integral boundary condition. We
establish some sufficient conditions for the existence of at least one or
two monotone and convex positive solutions. Furthermore, the nonexistence
results of positive solution are also considered. As applications, two
examples are presented to illustrate the validity of our main results.