2010
DOI: 10.1212/wnl.0b013e3181fb3638
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Approach to acute or subacute myelopathy

Abstract: 2010;75(Suppl 1):S2-S8

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Cited by 44 publications
(41 citation statements)
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“…The etiology of long segment spinal cord lesions is frequently uncertain at presentation; therefore, empiric treatment with high-dose IV corticosteroids should be initiated while evaluation is underway. 6 It was believed that more aggressive therapy was necessary in our case given the severity of the spinal cord lesion and recurrence of symptoms. Thus, azathioprine was also initiated.…”
Section: Discussionmentioning
confidence: 78%
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“…The etiology of long segment spinal cord lesions is frequently uncertain at presentation; therefore, empiric treatment with high-dose IV corticosteroids should be initiated while evaluation is underway. 6 It was believed that more aggressive therapy was necessary in our case given the severity of the spinal cord lesion and recurrence of symptoms. Thus, azathioprine was also initiated.…”
Section: Discussionmentioning
confidence: 78%
“…6 MRI characteristics may also aid in diagnosis as certain patterns of signal abnormality may predict particular etiologies. Sarcoidosis of the spinal cord may appear as smooth or nodular leptomeningeal enhancement with patchy peripheral cord enhancement.…”
Section: Discussionmentioning
confidence: 99%
“…Paraneoplastic disorders may have multifocal involvement. 8 In a recent case series, 65% of cases showed T2 abnormalities; 70% showed longitudinal extent of lesion exceeding 3 vertebral segments. 6 Although antibodies are not required for the diagnosis of paraneoplastic myelopathy, antibodies that are frequently associated are ANNA-1 (anti-Hu; 11%-60%), anti-amphiphysin (24%), ANNA-2 (anti-Ri; 18%), ANNA-3 (18%), anti-CRMP5 (16%), PCA-2 (10%), PCA-1 (anti-Yo; 5%), anti-Ma (4%), and anti-Ta (3%).…”
Section: Sectionmentioning
confidence: 93%
“…Risk factors for cancer should increase suspicion for paraneoplastic syndrome. 8 Paraneoplastic myelopathy is frequently associated with lung and breast cancer. 9 Spine MRI with contrast often reveals symmetrical hyperintense T2 lesions confined to individual tracts.…”
Section: Sectionmentioning
confidence: 99%
“…For example, neuromuscular junction diseases such as myasthenia gravis, Lambert-Eaten syndrome, cranial pathologies such as bilateral anterior cerebral artery infarction, bilateral medial frontal lobe injury, brain stem tumors, amyotrophic lateral sclerosis among degenerative diseases, hypokalemia among metabolic causes, Guillain-Barre syndrome causing peripheral nerve impairment, and gait disorders due to psychogenic causes may be confused with myelopathy. These clinical conditions should be questioned and screened in patients who present with paraparesis (7,8).…”
mentioning
confidence: 99%