Approaches to mixture risk assessment of PFASs in the European population based on human hazard and biomonitoring data

Bil, Wieneke; Govarts, Eva; Zeilmaker, Marco J.; Woutersen, Marjolijn; Bessems, Jos; Ma, Yula; Thomsen, Cathrine; Haug, Line Småstuen; Lignell, Sanna; Gyllenhammar, Irina; Murínová, Ľubica Palkovičová; Fábelová, Lucia; Tratnik, Janja Snoj; Kosjek, Tina; Gabriel, Catherine; Sarigiannis, Dimosthenis; Pedraza-Dı́az, Susana; Esteban, Marta; Castaño, Argelia; Rambaud, Loı̈c; Riou, Margaux; Franken, Carmen; Colles, A.; Vogel, Nina; Kolossa-Gehring, Marike; Halldórsson, Thorhallur I.; Uhl, Maria; Schoeters, Greet; Santonen, Tiina; Vinggaard, Anne Marie

doi:10.1016/j.ijheh.2022.114071

Cited by 21 publications

(6 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PFASs released during production or during the product life stage remain in the environment and will remain a source of exposure for generations to come. For some PFASs, specifically those already phased out or restricted under REACH in the EU, combined exposure already exceeds existing limit values for highly exposed communities in the population (section 1.1.4.9; (Bil et al, 2023;Olsen et al, 2007;Richterová et al, 2023;Schillemans et al, 2023)). Any additional exposure to other PFASs, that are to date less well investigated but for which comparable effects have already been demonstrated or can be expected because of structural similarities, will contribute to the magnitude of negative human health impacts in the future.…”

Section: Human Health Impactsmentioning

confidence: 97%

“…Considering the increasing lines of evidence for effects of well-studied PFASs occurring at lower levels than previously anticipated (EFSA, 2020), the human exposure to the combination of the four PFASs PFOA, PFNA, PFHxS, and PFOS already exceeds the existing limit value established by EFSA. Also recent human biomonitoring data on PFAS from the HBM4EU program confirm that PFAS exposure is too high and may result in a human health risk (Bil et al (2023); see also Annex B.9.22.2.). Furthermore, remediation/decontamination of PFASs from the environment and drinking water is insufficient with current conventional and advanced treatment methods (see Annex B.4.5.).…”

Section: Conclusion On Human Health Effects/concernsmentioning

confidence: 99%

See 1 more Smart Citation

EU proposal would ban 10,000 PFAS

Erickson¹

2023

C&EN

View full text Add to dashboard Cite

show abstract

Section: Human Health Impactsmentioning

confidence: 97%

Section: Conclusion On Human Health Effects/concernsmentioning

confidence: 99%

EU proposal would ban 10,000 PFAS

Erickson¹

2023

C&EN

View full text Add to dashboard Cite

show abstract

“…Humans can be exposed to PFASs through the ingestion of contaminated foods, air inhalation, dust ingestion, and dermal contact [6,7]. Several studies investigated the presence of PFASs in human blood [8][9][10][11][12][13][14]. Levels of perfluorooctanesulfonic acid (PFOS), perfluorooctanoic acid (PFOA), and perfluorohexanesulfonic acid (PFHxS) were found in blood samples collected from infants aged 3 months (1.48, 2.40, and 0.43 ng mL −1 , respectively) [15] and human placental samples (0.242, 0.150, and 0.091 ng g −1 ) [16], confirming the PFAS transfer from mother to fetus [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

There’s Something in What We Eat: An Overview on the Extraction Techniques and Chromatographic Analysis for PFAS Identification in Agri-Food Products

Iannone,

Carriera,

Passarella

et al. 2024

Foods

View full text Add to dashboard Cite

Per- and polyfluorinated alkyl substances (PFASs) are a group of anthropogenic chemicals used in a range of industrial processes and consumer products. Recently, their ubiquitous presence in the environment as well as their toxicological effects in humans have gained relevant attention. Although the occurrence of PFASs is widely investigated in scientific community, the standardization of analytical method for all matrices still remains an important issue. In this review, we discussed extraction and detection methods in depth to evaluate the best procedures of PFAS identification in terms of analytical parameters (e.g., limits of detection (LODs), limits of quantification (LOQs), recoveries). Extraction approaches based on liquid–liquid extraction (LLE), alkaline digestion, and solid phase extraction (SPE), followed by liquid chromatography–mass spectrometry (LC-MS) and gas chromatography–mass spectrometry (GC-MS) analysis are the main analytical methods applied in the literature. The results showed detectable recoveries of PFOA and PFOS in meat, milk, vegetables, eggs products (90.6–101.2% and of 89.2–98.4%), and fish (96–108%). Furthermore, the low LOD and LOQ values obtained for meat (0.00592–0.01907 ng g−1; 0.050 ng g−1), milk (0.003–0.009 ng g−1; 0.010–0.027 ng g−1), fruit (0.002–0.009 ng g−1; 0.006–0.024 ng g−1), and fish (0.00369–0.017.33 ng g−1; 0.05 ng g−1) also confirmed the effectiveness of the recent quick, easy, cheap, effective, rugged, and safe method (QuEChERS) for simple, speedy, and sensitive ultra-trace PFAS analysis.

show abstract

“…PFAS exposure in the general population can occur through multiple routes, including ingestion of contaminated foods and/or drinking water and direct contact with PFAS-containing consumer products and ocular device (Domingo and Nadal, 2019;Glüge et al, 2020;Kang et al, 2024;Ragnarsdóttir et al, 2022). Indeed, detectable levels of PFAS exposure biomarkers in serum samples from the general population have been consistently reported worldwide including the U.S. (Calafat et al, 2019), Europe (Bil et al, 2023), and Asia (Seo et al, 2018;Tsai et al, 2018;Zeeshan et al, 2020). Growing epidemiological evidence suggests possible associations between PFAS exposure and various health outcomes, including liver damage (Costello et al, 2022), hyperlipidemia (ATSDR, 2021;Winquist and Steenland, 2014), diabetes (Gui et al, 2023), and reproductive disorders (ATSDR, 2021;Ding et al, 2020), indicating underlying mechanisms including oxidative stress and metabolic and endocrine disruption.…”

Section: Introductionmentioning

confidence: 99%

Exposure to per- and polyfluoroalkyl substances and age-related macular degeneration in U.S. middle-aged and older adults

Kang,

Park,

Kim

et al. 2024

Preprint

View full text Add to dashboard Cite

Despite various health effects of per- and polyfluoroalkyl substances (PFAS) exposure, the association between PFAS exposure and age-related macular degeneration (AMD) has not been investigated. We aimed to assess associations of PFAS exposure with AMD, using data from 1,722 U.S. adults aged 40 years or more participating in the National Health and Nutrition Examination Survey 2005-2008 with complete data on PFAS measurement, AMD diagnosis, and covariates. Serum concentrations of PFAS, including perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorohexane sulfonic acid (PFHxS), and perfluorooctane sulfonic acid (PFOS), were measured. An overall PFAS burden score was calculated using item response theory scoring. Individual PFAS concentration and overall PFAS burden score were categorized into low (reference), medium, and high groups. Diagnosis of AMD was based on retinal image examination. Any AMD was defined as the presence of early or late AMD. Survey-weighted logistic regression adjusted for potential confounders was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for presence of AMD according to PFAS exposure. Overall, 132 (6.5%) individuals were diagnosed as any AMD, including 115 (5.7%) individuals with early AMD. A significant dose-response association was observed between serum PFOS concentration and any AMD (p-trend=0.03), with a significant OR of 1.99 (95% CI: 1.05, 3.79) for the high group compared to the reference. Overall PFAS burden showed a non-monotonic association with any AMD, with a significant OR of 2.18 (95% CI: 1.18, 4.04) for the medium. Inverted U-shaped associations were observed by restricted cubic spline analyses. Also, early AMD showed similar patterns in PFOS and overall PFAS burden and additionally an inverted U-shape association in PFNA. Our findings suggest that exposure to PFAS estimated by serum PFOS and PFNA as well as overall PFAS burden might be a risk factor for AMD in middle-aged and older population.

show abstract

Approaches to mixture risk assessment of PFASs in the European population based on human hazard and biomonitoring data

Cited by 21 publications

References 29 publications

EU proposal would ban 10,000 PFAS

EU proposal would ban 10,000 PFAS

There’s Something in What We Eat: An Overview on the Extraction Techniques and Chromatographic Analysis for PFAS Identification in Agri-Food Products

Exposure to per- and polyfluoroalkyl substances and age-related macular degeneration in U.S. middle-aged and older adults

Contact Info

Product

Resources

About