Appropriateness of timing of drug administration in electronic prescriptions

Hassan, Arwa; Haefeli, Walter E.

doi:10.1007/s11096-009-9362-4

Cited by 12 publications

(7 citation statements)

References 49 publications

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“…These results are in line with previous study conducted on similar cohorts assessing their viewpoints about and experience with application of chronotherapy principles in practice and also consistent with another study that assessed the awareness and attitudes of final year pharmacy students towards chronotherapy ; both studies reported a lack of awareness about current therapeutic evidence on chronotherapy. This study revealed that only (44.8%) of the community pharmacists provided correct answers to evidence based recommended time for Perindopril (Hermida et al, 2011;Hassan & Haefeli, 2010).…”

Section: Discussionmentioning

confidence: 86%

“…Administering medications at certain time of the day is a noteworthy factor especially during patient management and care . Several studies have reported that therapeutic outcome of drugs maybe improved following medication administration at certain times of the day (Kaur et al, 2013;Hassan & Haefeli, 2010;Lemmer, 2005;Huang et al, 2011). Since it has been established that both pharmacokinetics and pharmacodynamics are affected by variations in biologic rhythms, it is therefore necessary to consider these variations prior to administration of medications.…”

Section: Introductionmentioning

confidence: 99%

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Assessment of Awareness and Attitudes of Community Pharmacists in Northwest Nigeria towards Chronotherapy

Chukwunyere¹,

Abacıoğlu²

2017

IJMP

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Introduction: Good practice and application of chronotherapy can optimize therapeutic benefits; however, these benefits can be compromised by poor knowledge and nonchalant attitude towards the application of principles of chronotherapy during patient management and care. Aim: The aim of this study was to assess the awareness and attitudes towards chronotherapy among community pharmacists practicing in Northwest region of Nigeria. Materials & methods:This cross sectional study utilized a modified questionnaire based on current literature and it was designed to consist of 27 items which explored the respondents' demographics, knowledge and attitudes towards chronotherapy. Results: Out of 131 filled survey instruments, 125 were included in this study as 6 were excluded due some missing data. Data analysis showed that awareness was influenced by age and years of practice. Mean total awareness and attitude scores were 8.49 ± 1.38 and 46.19 ± 5.92 respectively. Spearman's rank-order correlation showed a statistically significant (p= 0.015) positive correlation (r=0.216) between awareness and attitude. Conclusion: The findings from this study highlight the need for a comprehensive chronotherapy-related educational program for both future and practicing community pharmacists.

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Section: Discussionmentioning

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Assessment of Awareness and Attitudes of Community Pharmacists in Northwest Nigeria towards Chronotherapy

Chukwunyere¹,

Abacıoğlu²

2017

IJMP

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“…Knowledge about circadian influence on the therapeutic effect of medicine should be used during patient counselling, especially if the medicine is being taken for the first time. A recent research program in Germany developed a database containing optimum timing of drug administration that could help to optimise treatment regimens in clinical practice [ 100 ]. Healthcare professionals should benefit from readily available knowledge about which medicine has evidence supporting chronotherapy so that patient outcomes can be improved.…”

Section: Resultsmentioning

confidence: 99%

Timing of Administration: For Commonly-Prescribed Medicines in Australia

et al. 2016

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Chronotherapy involves the administration of medication in coordination with the body’s circadian rhythms to maximise therapeutic effectiveness and minimise/avoid adverse effects. The aim of this study is to investigate the “time of administration” recommendations on chronotherapy for commonly-prescribed medicines in Australia. This study also aimed to explore the quality of information on the timing of administration presented in drug information sources, such as consumer medicine information (CMI) and approved product information (PI). Databases were searched for original research studies reporting on the impact of “time of administration” of the 30 most commonly-prescribed medicines in Australia for 2014. Further, time of administration recommendations from drug information sources were compared to the evidence from chronotherapy trials. Our search revealed 27 research studies, matching the inclusion and exclusion criteria. In 56% (n = 15) of the research studies, the therapeutic effect of the medicine varied with the time of administration, i.e., supported chronotherapy. For some medicines (e.g., simvastatin), circadian-based optimal administration time was evident in the information sources. Overall, dedicated studies on the timing of administration of medicines are sparse, and more studies are required. As it stands, information provision to consumers and health professionals about the optimal “time” to take medications lags behind emerging evidence.

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“…Broadly referred to as chronotherapy, the administration of medications at optimal circadian times represents a multifaceted concept that exploits diverse mechanisms and principles such as formulation science, pharmacology, physiology, and pathophysiology [ 1 , 2 ]. Though not applicable in all cases, chronotherapy may be of significance in disease conditions that exhibit circadian variability such as asthma, gastroesophageal reflux, cardiovascular diseases, cancer, metabolic diseases, rheumatoid arthritis and sleep disorders [ 3 , 4 , 5 , 6 ]. Further, evidence from the various clinical effectiveness and drug disposition studies demonstrates improved outcomes when the administration of certain medications is timed in synchrony with circadian patterns [ 4 , 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

“…Though not applicable in all cases, chronotherapy may be of significance in disease conditions that exhibit circadian variability such as asthma, gastroesophageal reflux, cardiovascular diseases, cancer, metabolic diseases, rheumatoid arthritis and sleep disorders [ 3 , 4 , 5 , 6 ]. Further, evidence from the various clinical effectiveness and drug disposition studies demonstrates improved outcomes when the administration of certain medications is timed in synchrony with circadian patterns [ 4 , 7 , 8 ]. A prime example is that of the statins, where short-acting statins are more effective when administered at night time, the circadian point when cholesterol synthesis is at its peak and HMG-CoA reductase enzyme exhibits maximal activity [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Education Intervention on Chronotherapy for Final-Year Pharmacy Students

et al. 2015

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Chronotherapy involves altering the timing of medication administration in coordination with the body’s circadian rhythms to improve the overall control of disease and to minimise treatment side effects. Training on chronotherapy requires students to map different topics learnt in earlier years of their professional degree and apply these concepts clinically. This requires strategic educational design. Therefore, the aim of the study was to develop, implement and evaluate an educational intervention focusing on the application of chronotherapy for final-year undergraduate pharmacy students. An educational intervention utilizing multiple learning strategies for enhancing chronotherapy related awareness was designed and implemented in the final year undergraduate pharmacy cohort at the University of Sydney Australia (2013). A custom-designed questionnaire measuring awareness about (13 items scored 0 or 1), and attitudes (12 items scored on a Likert scale of 1–5) towards chronotherapy was administered pre and post intervention to evaluate its impact. The pre-intervention mean total awareness and attitude scores were 6.5 ± 2.0 (score range 0–13) and 47.4 ± 6.9 (score range 12–60) respectively. The mean total post-intervention scores were significantly higher for total awareness (10.1 ± 1.9) and attitude (54.0 ± 6.0). Carefully designed educational interventions utilising pedagogic principles for pharmacy students can improve awareness of and enhance positive attitudes toward pharmacists’ roles in optimizing drug therapy using chronotherapy.

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Appropriateness of timing of drug administration in electronic prescriptions

Cited by 12 publications

References 49 publications

Assessment of Awareness and Attitudes of Community Pharmacists in Northwest Nigeria towards Chronotherapy

Assessment of Awareness and Attitudes of Community Pharmacists in Northwest Nigeria towards Chronotherapy

Timing of Administration: For Commonly-Prescribed Medicines in Australia

Education Intervention on Chronotherapy for Final-Year Pharmacy Students

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