Aptamer-templated silver nanoclusters embedded in zirconium metal–organic framework for targeted antitumor drug delivery

Su, Fangfang; Jia, Qiaojuan; Li, Zhenzhen; Wang, Minghua; He, Linghao; Peng, Donglai; Song, Yingpan; Fang, Shaoming

doi:10.1016/j.micromeso.2018.08.026

Cited by 166 publications

(56 citation statements)

References 49 publications

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“…Various types of surface modication of metal NCs, such as aptamer, specic peptides, glucose, DNA, and folic acid have been developed for efficient delivery of the metal NCs to the target (e.g., cancerous tumors) for in vivo applications. [151][152][153][154][155][156] Further studies involving active targeting of metal NCs would be important for in vivo PDT applications.…”

Section: Discussionmentioning

confidence: 99%

Photo/electrocatalysis and photosensitization using metal nanoclusters for green energy and medical applications

2020

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Section: Discussionmentioning

confidence: 99%

Photo/electrocatalysis and photosensitization using metal nanoclusters for green energy and medical applications

2020

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“…Su et al [118] developed a multifunctional-targeted antitumor DDS based on the nanocomposite of zirconium MOF, UiO-66 embedded with silver nanoclusters using a one-pot encapsulation method. Confocal laser scanning microscopy revealed that aptamer-modified UiO-66@AgNCs@Apt was effectively taken up and internalized by target cancer cells with profound selectivity.…”

Section: Mofs For Drug Deliverymentioning

confidence: 99%

“…In vitro cellular uptake and drug delivery analysis showed that UiO-66@AgNCs@Apt@DOX nanocomposite was internalized by AS1411-driven endocytosis, and the released doxorubicin effectively targeted to the nucleus serving as promising in vivo DDS. Cell compatibility test represents that the synthesized nano-construct exhibited negligible toxicity to MCF-7 cell in a broader concentration range, and the drug preparations exhibit target-oriented delivery of doxorubicin and controlled intracellular release resulting in enhanced and robust in vitro antitumor activity [118]. More recently, a hydrophobic nano DDS was designed using RGD (Arg-Gly-Asp) modified camptothecin@zeolitic imidazolate framework-8 (RGD@CPT@ZIF-8) as a unique MOF for enhanced and targeted cancer therapy [119].…”

Section: Mofs For Drug Deliverymentioning

confidence: 99%

Metal-Organic Framework-Based Engineered Materials—Fundamentals and Applications

et al. 2020

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Metal-organic frameworks (MOFs) are a fascinating class of porous crystalline materials constructed by organic ligands and inorganic connectors. Owing to their noteworthy catalytic chemistry, and matching or compatible coordination with numerous materials, MOFs offer potential applications in diverse fields such as catalysis, proton conduction, gas storage, drug delivery, sensing, separation and other related biotechnological and biomedical applications. Moreover, their designable structural topologies, high surface area, ultrahigh porosity, and tunable functionalities all make them excellent materials of interests for nanoscale applications. Herein, an effort has been to summarize the current advancement of MOF-based materials (i.e., pristine MOFs, MOF derivatives, or MOF composites) for electrocatalysis, photocatalysis, and biocatalysis. In the first part, we discussed the electrocatalytic behavior of various MOFs, such as oxidation and reduction candidates for different types of chemical reactions. The second section emphasizes on the photocatalytic performance of various MOFs as potential candidates for light-driven reactions, including photocatalytic degradation of various contaminants, CO2 reduction, and water splitting. Applications of MOFs-based porous materials in the biomedical sector, such as drug delivery, sensing and biosensing, antibacterial agents, and biomimetic systems for various biological species is discussed in the third part. Finally, the concluding points, challenges, and future prospects regarding MOFs or MOF-based materials for catalytic applications are also highlighted.

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“…Biological Imaging. In the past decades, fluorescent biological imaging technology which is the process of light emission in living organisms [161] became an indispensable and visualized tool for the drug delivery system [162,163], gene therapy [164], and cancer diagnoses [165,166]. The used fluorophore is a key point for successful bioimaging of cells, 21 Journal of Nanomaterials which concerns about their safety, sensitivity, and wide applicability.…”

Section: Biological Applications Of Platinum Nanoclustersmentioning

confidence: 99%

Recent Advances in the Synthesis, Properties, and Biological Applications of Platinum Nanoclusters

Huang

et al. 2019

Journal of Nanomaterials

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Noble metal nanoclusters (M NCs), defined as an aggregation of a few to tens of atoms, are considered a borderline between atoms and metal nanoparticles (M NPs), which tends to exhibit molecule-like behaviours such as discrete electronic state and size-dependent fluorescence. In the past decades, gold and silver nanoclusters (Au NCs and Ag NCs) have been massively explored and utilized in the field of industrial catalysis, optoelectronic devices, biological imaging, environmental detection, clinical diagnoses, and treatment. The analogue of Au and Ag NCs and platinum nanoclusters (Pt NCs), especially their biological applications, is relatively and rarely discussed. This review firstly investigates the synthetic methodology of Pt NCs including template-assisted and template-free approaches and then introduces their unique optical, catalytic, and thermal properties. Particular importance here is the biological applications of Pt NCs such as the bioimaging of various cells as a preferred fluorophore in contrast to traditional fluorescent markers (e.g., organic dye, semiconductor quantum dots, and fluorescent proteins), the usage of Pt NCs-based antitumour drugs as a new class chemotherapeutics for malignant tumour therapy, and the utilization of antibacteria as an alternative of Ag-based antibacterial agent. On the whole, the development of Pt NCs has already gained delectable progress; however, the study of ultrafine Pt NCs is at the beginning stage and there are still plenty of challenges like synthesis of near-infrared (NIR) fluorescent Pt NCs, the explicit signal pathway of cell apoptosis, and attempt in diverse biological applications that need to be urgently tackled in future.

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Aptamer-templated silver nanoclusters embedded in zirconium metal–organic framework for targeted antitumor drug delivery

Cited by 166 publications

References 49 publications

Photo/electrocatalysis and photosensitization using metal nanoclusters for green energy and medical applications

Photo/electrocatalysis and photosensitization using metal nanoclusters for green energy and medical applications

Metal-Organic Framework-Based Engineered Materials—Fundamentals and Applications

Recent Advances in the Synthesis, Properties, and Biological Applications of Platinum Nanoclusters

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