Apuntes sobre recidivas y segundos tumores en el cáncer de pulmón

Álvarez, Felipe Villar; Trueba, Ignacio Muguruza; Antunes, Sara Isabel Vicente

doi:10.1016/j.arbres.2016.03.004

Cited by 3 publications

(1 citation statement)

References 9 publications

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“…Lung cancer is a serious health problem with a very strong impact from both the healthcare and socio-economic points of view. The relapse rate in stage I NSCLC lies between 10% and 30% according to consulted authors [9][10][11]. In our series, 28.6% of the patients suffered relapse, of whom 70.6% had distance relapse, mainly in the brain, and 25.2% of them died from this disease.…”

Section: Discussionmentioning

confidence: 49%

Angiogenesis as a prognostic factor of pathological stage IA lung adenocarcinoma: developing an angiogenic score

Quevedo¹,

Saurı́²,

Navarro³

et al. 2020

J Transl Sci

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Purpose: This work was designed to correlate the expression of markers of tumoral angiogenesis in lung adenocarcinoma as a prognostic factor and create a predictive model with these factors.Patients and methods: A clinical, observational and analytical research study was undertaken. This work sought to describe and compare prognosis value of angiogenic markers of 119 resected patients, classified as pathological stage IA. The tumour angiogenesis analysis was performed, the survival and predictive value of microvascular density (MVD) expression with tumoral relapse and survival were evaluated. Finally, an accurate score, "Angioscore", was calculated by combining different markers.Results: Low MVD-CD34 is associated with a worse disease-free survival (DFS) and cancer specific survival (CSS). High MVD-CD31 is significantly related to reduce DFS and CSS. High MVC-CD105 is associated with worse clinical outcomes. The predictive capacity of these angiogenic markers independently it is not exact. The "Angioscore" is able to provide better information about patient prognosis (74.8% and 73.7%). Two groups were obtained with the risk value obtained by "Angioscore". A significant difference in the prognosis of both groups was accomplished (p < 0.001). Being in the multivariate analysis the only independent prognostic factor in patients with lung ADC in stage IA of this series. Conclusion:Tumour angiogenesis is a prognostic factor in early stage lung adenocarcinoma, the analysis of this factor being more accurate using a score, with great predictive value for the prognosis of patients.Prognostic factors aim to predict the probability of an event occurring in cancer, mortality or relapse. However, a single factor is not usually helpful for this purpose. Therefore, it is necessary to create predictive models or risk scores that include a combination of prognostic factors, and to more precisely approach the probability of the event under study. This work was designed to investigate and correlate the expression of markers of tumoural angiogenesis in lung ADC as a prognostic factor in resected patients classified as pathological stage IA according to the 8th edition of the TNM classification to establish risk groups, and to create a new score that better stratifies patients with stage IA lung ADC.De Aguiar-Quevedo K (2020) Angiogenesis as a prognostic factor of pathological stage IA lung adenocarcinoma: developing an angiogenic score

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Section: Discussionmentioning

confidence: 49%

Angiogenesis as a prognostic factor of pathological stage IA lung adenocarcinoma: developing an angiogenic score

Quevedo¹,

Saurı́²,

Navarro³

et al. 2020

J Transl Sci

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Relationships between chronic obstructive pulmonary disease and lung cancer: biological insights

Barreiro¹,

Bustamante

Curull³

et al. 2016

J. Thorac. Dis.

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Lung cancer (LC) has become one of the leading causes of preventable death in the last few decades. Cigarette smoking (CS) stays as the main etiologic factor of LC despite that many other causes such as occupational exposures, air pollution, asbestos, or radiation have also been implicated. Patients with chronic obstructive pulmonary disease (COPD), which also represents a major cause of morbidity and mortality in developed countries, exhibit a significantly greater risk of LC. The study of the underlying biological mechanisms that may predispose patients with chronic respiratory diseases to a higher incidence of LC has also gained much attention in the last few years. The present review has been divided into three major sections in which different aspects have been addressed: (I) relevant etiologic agents of LC; (II) studies confirming the hypothesis that COPD patients are exposed to a greater risk of developing LC; and (III) evidence on the most relevant underlying biological mechanisms that support the links between COPD and LC. Several carcinogenic agents have been described in the last decades but CS remains to be the leading etiologic agent in most geographical regions in which the incidence of LC is very high. Growing evidence has put the line forward the implications of COPD and especially of emphysema in LC development. Hence, COPD represents a major risk factor of LC in patients. Different avenues of research have demonstrated the presence of relevant biological mechanisms that may predispose COPD patients to develop LC. Importantly, the so far identified biological mechanisms offer targets for the design of specific therapeutic strategies that will further the current treatment options for patients with LC. Prospective screening studies, in which patients with COPD should be followed up for several years will help identify biomarkers that may predict the risk of LC among these patients.

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Role of LASP-1, a novel SOX9 transcriptional target, in the progression of lung cancer

Shi

Guo

2017

Int J Oncol

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Lung cancer accounts for most cancer-related deaths worldwide. However, the underlying mechanism by which it mediates the progression of lung cancer remains unclear. Expression of LASP-1 (LIM and SH3 protein 1) was evaluated in lung cancer tissues and tumor-adjacent normal tissues using immunohistochemistry and western blotting. Functional studies have shown that siRNA-mediated silencing of LASP-1 in human lung cancer cells and reduced cell proliferation, migration, and invasion. Flow cytometry and immunofluorescence staining also revealed that rate of cell apoptosis was increased after knockdown of expression of LASP-1, thereby suggesting that LASP-1 may function as an oncogene during lung cancer progression. SOX9 is an important transcription factor, which is involved in the development of several types of human cancer. Further analysis has showed the presence of a consensus-binding site of SOX9 in the promoter region of LASP-1. Mechanistic investigations showed that LASP-1 was transcriptionally activated by SOX9. Through luciferase reporter and ChIP assays, we demonstrated that LASP-1 was a direct target gene of sex determining region Y-box 9 (SOX9). Knockdown of SOX9 expression by RNA interference reduces cell proliferation and induces apoptosis of lung cancer cells, which was consistent with the results obtained from silencing the expression of LASP-1 in NCI‑H1650 cells. Together, these findings indicated that LASP-1, as a downstream target of SOX9, may act as a novel biomarker for lung cancer and plays an important role in cell proliferation, migration, and invasion.

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Apuntes sobre recidivas y segundos tumores en el cáncer de pulmón

Cited by 3 publications

References 9 publications

Angiogenesis as a prognostic factor of pathological stage IA lung adenocarcinoma: developing an angiogenic score

Angiogenesis as a prognostic factor of pathological stage IA lung adenocarcinoma: developing an angiogenic score

Relationships between chronic obstructive pulmonary disease and lung cancer: biological insights

Role of LASP-1, a novel SOX9 transcriptional target, in the progression of lung cancer

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