Aquagenic Pruritus in Polycythemia Vera: Clinical Characteristics

Lelonek, Edyta; Matusiak, Łukasz; Wróbel, Tomasz; Szepietowski, Jacek C.

doi:10.2340/00015555-2906

Cited by 28 publications

(26 citation statements)

References 38 publications

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“…The mean BCC-associated itch intensity evaluated with NRS remains comparable with the intensity of itch in SCC (3.1-4.0 points) [11,13] and with melanoma-associated itch (3.3 ± 1.03 points) [11]. This intensity may also be commensurate with itch observed in neoplasms, such as polycythemia vera (4.8 ± 1.9 points) [17] or internal diseases, such as uraemic itch (4.1 ± 2.0 points) [30] or acute heart failure (4.2 ± 2.9 points) [31]. However, with regard to itching observed in other frequent dermatologic disorders, such as atopic dermatitis (7.9 ± 2.2 points) [32], psoriasis (6.6 ± 2.6 points) [25], or lichen planus (6.5 ± 2.7 points) [33] the intensity of itch measured with NRS or VAS in patients with BCC is much lower.…”

Section: Discussionsupporting

confidence: 60%

“…Interestingly, itch in melanoma was less common (5.3-28.8%) [3,11,[14][15][16]. Compared with hematologic neoplasms, commonly associated with itch, such as polycythemia vera (31-68%) [17][18][19] or Hodgkin's lymphoma (25-36.2%) [20,21], itching in BCC is less common. However, it occurs more frequently in comparison with non-Hodgkin's lymphoma (3.2-15.6%) [22,23] or itch in solid tumors (<1%) [24].…”

Section: Discussionmentioning

confidence: 99%

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Is Basal Cell Carcinoma an Itchy Tumor? Clinical Characteristics of Itch in Basal Cell Carcinoma

Chlebicka

Stefaniak

Matusiak

et al. 2020

JCM

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In common knowledge, basal cell carcinoma (BCC) is known to be asymptomatic, but in clinical practice, at least some patients complain of itching. The present study group comprised of 180 patients with histologically confirmed BCC. Detailed information on demographics, clinical history, and physical findings was recorded. Moreover, various clinical features of itch (including intensity, localization, quality, descriptors) and the most common factors responsible for its aggravation or alleviation were examined. The itch was present in 21.1% of patients with BCC and was limited to the tumor. The mean intensity of the itch was 3.1 ± 1.2 points (Numerical Rating Scale), indicating moderate itch intensity. Among the patients, 22.4% reported that itching occurred constantly, every day. BCC-associated itch seems to be moderately frequent, although being a seemingly underestimated problem among patients with BCC.

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Section: Discussionsupporting

confidence: 60%

Section: Discussionmentioning

confidence: 99%

Is Basal Cell Carcinoma an Itchy Tumor? Clinical Characteristics of Itch in Basal Cell Carcinoma

Chlebicka

Stefaniak

Matusiak

et al. 2020

JCM

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“…Of note, the onset of aquagenic pruritus often precedes the diagnosis of MPNs. 27 The pathogenesis of aquagenic pruritus is unclear, but a gene mutation, mast cells, and basophils are considered to play roles. [28][29][30] The Janus kinase (JAK) 2 gain-of-function mutation (JAK2V617F) is thought to be involved in the pathogenesis of PV and other MPNs.…”

Section: Hematologic Diseases Myeloproliferative Neoplasmsmentioning

confidence: 99%

Itching as a systemic disease

Hashimoto

Yosipovitch

2019

Journal of Allergy and Clinical Immunology

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Pruritus is a sensation that emanates from the skin and is transferred through peripheral nerve fibers to the central nervous system. It is easily understood that primary skin disorders, such as atopic eczema, skin dryness, psoriasis, and urticaria, can elicit pruritus. However, certain systemic diseases can cause chronic pruritus, which has a significant effect on the patient's quality of life. In this rostrum we provide an overview of the characteristics, pathophysiology, and mechanisms of pruritus of major systemic underlying diseases, including endstage renal disease, cholestatic liver disease, endocrine/ metabolic diseases, and hematologic/lymphoproliferative diseases.

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“…The occurrence of CI was noted, along with the location affected by the symptom. The detailed characteristics of CI (extensity, severity, frequency, sleep impairment) were assessed via 4Item Itch Questionnaire (4IIQ) (23)(24)(25)(26)(27). In addition, a modi fied questionnaire for the description of itch (28) was completed in order to determine the presence of itch in the last 3 days; maximal itch intensity in the last 3 days was assessed via a verbal rating scale (VRS; none, mild, moderate, severe, very severe) and a nu merical rating scale (NRS; 0=no itch, 10=maximal itch intensity); while an NRS was also used to assess the highest itch intensity during the course of the disease.…”

Section: Study Population and Designmentioning

confidence: 99%

Itch in Psoriasis: A New Look at Well-known Subject

Reszke¹,

Białynicki‐Birula²,

Szepietowski³

2019

Acta Derm Venerol

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SIGNIFICANCEPsoriasis is a chronic inflammatory cutaneous disease fre quently encountered in the general population. The majo rity of psoriatic patients experience chronic itch. The cur rent study has extensively evaluated the prevalence and clinical characteristics of chronic itch in a cohort of psoriatic subjects. Moreover, we have investigated clinical itch-rela ted differences between senior and non-senior groups of patients, as well as possible associations between chronic itch, systemic comorbidities and pharmacotherapy.Psoriasis is a chronic inflammatory dermatosis, frequently presenting with chronic itch. This study investigated the prevalence and detailed clinical characteristics of chronic itch in 143 psoriatic patients, with regard to different age groups, comorbidities and pharmacotherapy. Chronic itch was reported by 72% of subjects. Patients aged 65 years and over presented higher 4-Item Itch Questionnaire (4IIQ) scores (8.6 ± 3.4 vs. 7.4 ± 2.5 points; p = 0.03) and rarely experienced itching at midday (p = 0.009). Chronic itch correlated with aspirin intake and xerosis intensity. 4IIQ scores were higher in patients with asthma/chronic obstructive pulmonary disease, peptic ulcer disease and those taking insulin. Logistic regression analysis found that chronic itch was positively correlated with the use of antacids, angiotensin receptor blockers, angiotensin enzyme converting inhibitors, beta-blockers, xerosis intensity and Physician's Global Assessment score, whereas psychiatric drugs other than selective serotonin reuptake inhibitors, allopurinol, coexistence of arterial hypertension and application of emollients acted conversely. Elderly psoriatic patients present several differences in the characteristics of chronic itch, and chronic itch may be associated with comorbidities and pharmacotherapy. To the best of our knowledge, this is the first study to report possible associations between psoriatic pruritus and co-administration of drugs utilized in various systemic conditions. ActaDV ActaDV Advances in dermatology and venereologyActa Dermato-Venereologica R. Reszke et al. 430 www.medicaljournals.se/acta ActaDV ActaDV Advances in dermatology and venereology Acta Dermato-Venereologica R. Reszke et al. 432 www.medicaljournals.se/acta ActaDV ActaDV Advances in dermatology and venereology Acta Dermato-Venereologica 433 Itch in psoriasis Acta Derm Venereol 2019 ActaDV ActaDV Advances in dermatology and venereology Acta Dermato-Venereologica R. Reszke et al. 434

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Aquagenic Pruritus in Polycythemia Vera: Clinical Characteristics

Cited by 28 publications

References 38 publications

Is Basal Cell Carcinoma an Itchy Tumor? Clinical Characteristics of Itch in Basal Cell Carcinoma

Is Basal Cell Carcinoma an Itchy Tumor? Clinical Characteristics of Itch in Basal Cell Carcinoma

Itching as a systemic disease

Itch in Psoriasis: A New Look at Well-known Subject

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