Aquagenic wrinkling of the palms

Palmar wrinkling after water exposure in a child

“…The lesions may be accompanied by pruritus or a burning sensation, independent of the water temperature, and usually disappear within 60 minutes after the end of water exposure [5,6]. The condition is associated with several disorders, such as focal hyperhidrosis, atopic dermatitis and Raynaud's syndrome [7].…”

“…However, the strongest association seems to be with CF or CF carrier state, since AWP is regarded as a clinical sign of CF and occurs in about 80 % of CF patients and 25 % of CF carriers. Cystic fibrosis is caused by a mutation of the CFTR gene, and leads to dysregulation of electrolyte transport [6,7].…”

Schwellung und Faltenbildung der Hände nach Wasserkontakt bei einem Kind

“…Die Läsionen können von Juckreiz oder Brennen begleitet sein, sind unabhängig von der Wassertemperatur und bilden sich in der Regel innerhalb von 60 Minuten nach Beendigung der Wasserexposition zurück [5,6]. Verschiedene Erkrankungen sind mit dem AA assoziiert, beispielsweise die fokale Hyperhidrose, die atopische Dermatitis und das Raynaud-Phänomen [7]. Arzneimittelinduzierte Fälle (Nebenwirkung von Cyclooxygenase-2-Inhibitoren) sowie idiopathische Formen wurden ebenfalls in der Literatur beschrieben [8,9].…”

Water‐related dermatoses

“…It has been proposed that a decrease in the skin barrier function along with an increased salt concentration alter the physiologic response, exaggerating the normal wrinkling experience (Fig. ) …”

“…1). 30,31 In order to understand the proposed mechanisms, keeping in mind the association of AWP with hyperhidrosis, we will shed light on the physiologic process of sweating. It first starts with the secretion of an isotonic solution in the secretory coil which is modified by the reabsorption of sodium and chloride ions to form a hypotonic solution.…”