Aquaporin Function: Seek and You Shall Find!

Brown, Dennis

doi:10.1093/function/zqaa041

Cited by 1 publication

(1 citation statement)

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“…The most recently discovered family members are in a separate grouping designated as 'superaquaporins' (AQP11 and AQP12). However, this functional categorization does not capture the diversity within the subgroups, with some orthodox isoforms having a broader substrate selectivity (e.g., urea permeates AQP8; Table 1) [10]. Distinct members of all three groups facilitate hydrogen peroxide transport; the superaquaporins facilitate both water and glycerol transport when purified and reconstituted into polymersomes (although their intracellular localization makes cell-based assays challenging) [11].…”

Section: Aquaporin Structure Function and Classificationmentioning

confidence: 99%

Recent breakthroughs and future directions in drugging aquaporins

Salman

Kitchen

Yool

et al. 2022

Trends in Pharmacological Sciences

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Aquaporins facilitate the passive transport of water, solutes, or ions across biological membranes. They are implicated in diverse pathologies including brain edema following stroke or trauma, epilepsy, cancer cell migration and tumor angiogenesis, metabolic disorders, and inflammation. Despite this, there is no aquaporin-targeted drug in the clinic and aquaporins have been perceived to be intrinsically nondruggable targets. Here we challenge this idea, as viable routes to inhibition of aquaporin function have recently been identified, including targeting their regulation or their roles as channels for unexpected substrates. Identifying new drug development frameworks for conditions associated with disrupted water and solute homeostasis will meet the urgent, unmet clinical need of millions of patients for whom no pharmacological interventions are available.

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Section: Aquaporin Structure Function and Classificationmentioning

confidence: 99%