Aquaporins in development – a review

Liu, Huishu; Wintour, E. M.

doi:10.1186/1477-7827-3-18

Cited by 55 publications

(22 citation statements)

References 129 publications

(138 reference statements)

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“…The observation of AQP expression in the amnion led to the speculation that AQPs may be involved in facilitating amnion water transport through the intramembranous pathway, and thus may play an important role in regulating AFV (Liu and Wintour 2005;Beall et al 2007a, b;Liu et al 2008). However, their participation in AFV regulation has not been explored.…”

Section: Introductionmentioning

confidence: 99%

Aquaporins in ovine amnion: responses to altered amniotic fluid volumes and intramembranous absorption rates

Cheung

Anderson

Brace

2016

Physiological Reports

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Aquaporins (AQPs) are transmembrane channel proteins that facilitate rapid water movement across cell membranes. In amniotic membrane, the AQP‐facilitated transfer of water across amnion cells has been proposed as a mechanism for amniotic fluid volume (AFV) regulation. To investigate whether AQPs modulate AFV by altering intramembranous absorption (IMA) rate, we tested the hypothesis that AQP gene expression in the amnion is positively correlated with IMA rate during experimental conditions when IMA rate and AFV are modified over a wide range. The relative abundances of AQP1, AQP3, AQP8, AQP9, and AQP11 mRNA and protein were determined in the amnion of 16 late‐gestation ovine fetuses subjected to 2 days of control conditions, urine drainage, urine replacement, or intraamniotic fluid infusion. AQP mRNA levels were determined by RT‐qPCR and proteins by western immunoblot. Under control conditions, mRNA levels among the five AQPs differed more than 20‐fold. During experimental treatments, mean IMA rate in the experimental groups ranged from 100 ± 120 mL/day to 1370 ± 270 mL/day. The mRNA levels of the five AQPs did not change from control and were not correlated with IMA rates. The protein levels of AQP1 were positively correlated with IMA rates (r 2 = 38%, P = 0.01) while the remaining four AQPs were not. These findings demonstrate that five AQPs are differentially expressed in ovine amnion. Our study supports the hypothesis that AQP1 may play a positive role in regulating the rate of fluid transfer across the amnion, thereby participating in the dynamic regulation of AFV.

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Section: Introductionmentioning

confidence: 99%

Aquaporins in ovine amnion: responses to altered amniotic fluid volumes and intramembranous absorption rates

Cheung

Anderson

Brace

2016

Physiological Reports

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“…AQP2 expression and the presence of the primary cilium are distinctive markers of principal cells, the exclusive cell type of the mature CD in the renal papilla (Liu & Wintour, 2005;Praetorius & Spring, 2005). As seen in Figure 6, the greater is the amount of glycoconjugates that bind DBA, the greater is the labeling for AQP2 ( Figure 6a-c, arrows).…”

Section: The Expression Of Aqp2 and The Primary Cilium Depends On Tmentioning

confidence: 95%

“…It is well known that as CD cells differentiate, they acquire the capacity to express aquaporin 2 (AQP2) expression, and form primary cilium (Liu & Wintour, 2005;Praetorius & Spring, 2005).…”

Section: The Expression Of Aqp2 and The Primary Cilium Depends On Tmentioning

confidence: 99%

Novel cellular mechanism that mediates the collecting duct formation during postnatal renal development

Guaytima

Brandán

Favale

et al. 2019

Journal Cellular Physiology

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We have previously demonstrated that kidney embryonic structures are present in rats, and are still developing until postnatal Day 20. Consequently, at postnatal Day 10, the rat renal papilla contains newly formed collecting duct (CD) cells and others in a more mature stage. Performing primary cultures, combined with immunocytochemical and time‐lapse analysis, we investigate the cellular mechanisms that mediate the postnatal CD formation. CD cells acquired a greater degree of differentiation, as we observed that they gradually lose the ability to bind BSL‐I lectin, and acquire the capacity to bind Dolichos biflorus. Because CD cells retain the same behavior in culture than in vivo, and by using DBA and BSL‐I as markers of cellular lineage besides specific markers of epithelial/mesenchymal phenotype, the experimental results strongly suggest the existence of mesenchymal cell insertion into the epithelial CD sheet. We propose such a mechanism as an alternative strategy for CD growing and development.

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“…Eleven of the 13 members have been identified from various mammalian tissue including the nervous system, kidney, gastrointestinal tract, skin and respiratory tract [52, 53]. …”

Section: The Aquaporin Familymentioning

confidence: 99%

Aquaporin Biology and Nervous System

Buffoli

2010

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Our understanding of the movement of water through cell membranes has been greatly advanced by the discovery of a family of water-specific, membrane-channel proteins: the Aquaporins (AQPs). These proteins are present in organisms at all levels of life, and their unique permeability characteristics and distribution in numerous tissues indicate diverse roles in the regulation of water homeostasis.Phenotype analysis of AQP knock-out mice has confirmed the predicted role of AQPs in osmotically driven transepithelial fluid transport, as occurs in the urinary concentrating mechanism and glandular fluid secretion. Regarding their expression in nervous system, there are evidences suggesting that AQPs are differentially expressed in the peripheral versus central nervous system and that channel-mediated water transport mechanisms may be involved in cerebrospinal fluid formation, neuronal signal transduction and information processing.Moreover, a number of recent studies have revealed the importance of mammalian AQPs in both physiological and pathophysiological mechanisms and have suggested that pharmacological modulation of AQP expression and activity may provide new tools for the treatment of variety of human disorders in which water and small solute transport may be involved. For all the AQPs, new contributions to physiological functions are likely to be discovered with ongoing work in this rapidly expanding field of research.

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Aquaporins in development – a review

Cited by 55 publications

References 129 publications

Aquaporins in ovine amnion: responses to altered amniotic fluid volumes and intramembranous absorption rates

Aquaporins in ovine amnion: responses to altered amniotic fluid volumes and intramembranous absorption rates

Novel cellular mechanism that mediates the collecting duct formation during postnatal renal development

Aquaporin Biology and Nervous System

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