Aquaporins in Immune System

Quan, Yazhu; Kan, Bo; Yang, Baoxue

doi:10.1007/978-981-19-7415-1_13

Cited by 5 publications

(5 citation statements)

References 35 publications

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“…This is the first demonstration of an aquaporin in microglial cells and the first evidence of a coupling between AQP9 and inflammatory responses in the brain. The role of AQP9 in microglia ties in with previous studies showing AQP9 expression in leukocytes and inflammatory responses in peripheral tissues [ 25 ].…”

Section: Discussionsupporting

confidence: 65%

Aquaporin-9 in the Brain Inflammatory Response: Evidence from Mice Injected with the Parkinsonogenic Toxin MPP+

et al. 2023

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More than 20 years have passed since the first demonstration of Aquaporin-9 (AQP9) in the brain. Yet its precise localization and function in brain tissue remain unresolved. In peripheral tissues, AQP9 is expressed in leukocytes where it is involved in systemic inflammation processes. In this study, we hypothesized that AQP9 plays a proinflammatory role in the brain, analogous to its role in the periphery. We also explored whether Aqp9 is expressed in microglial cells, which would be supportive of this hypothesis. Our results show that targeted deletion of Aqp9 significantly suppressed the inflammatory response to the parkinsonian toxin 1-methyl-4-phenylpyridinium (MPP+). This toxin induces a strong inflammatory response in brain. After intrastriatal injections of MPP+, the increase in transcript levels of proinflammatory genes was less pronounced in AQP9−/− mice compared with wild-type controls. Further, in isolated cell subsets, validated by flow cytometry we demonstrated that Aqp9 transcripts are expressed in microglial cells, albeit at lower concentrations than in astrocytes. The present analysis provides novel insight into the role of AQP9 in the brain and opens new avenues for research in the field of neuroinflammation and chronic neurodegenerative disease.

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Section: Discussionsupporting

confidence: 65%

Aquaporin-9 in the Brain Inflammatory Response: Evidence from Mice Injected with the Parkinsonogenic Toxin MPP+

et al. 2023

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“…Water-selective AQPs are involved in many biological functions, including transepithelial fluid transport, cell migration, brain edema, and neuroexcitation [13,14], whereas aquaglyceroporins are involved in cell proliferation, adipocyte metabolism, and epidermal water retention. Recent studies have shown that in immune systems, at least six AQPs, including AQP1, AQP3, AQP4, AQP5, AQP7, and AQP9, are expressed [13,[15][16][17]. These AQPs are distributed in lymphocytes, macrophages, dendritic cells, and neutrophils, and they mediate water and glycerol transportation in these cells, which play important roles in innate and adaptive immune functions.…”

Section: Introductionmentioning

confidence: 99%

AQP3 and AQP9—Contrary Players in Sepsis?

Thon,

Rahmel,

Ziehe

et al. 2024

IJMS

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Sepsis involves an immunological systemic response to a microbial pathogenic insult, leading to a cascade of interconnected biochemical, cellular, and organ–organ interaction networks. Potential drug targets can depict aquaporins, as they are involved in immunological processes. In immune cells, AQP3 and AQP9 are of special interest. In this study, we tested the hypothesis that these aquaporins are expressed in the blood cells of septic patients and impact sepsis survival. Clinical data, routine laboratory parameters, and blood samples from septic patients were analyzed on day 1 and day 8 after sepsis diagnosis. AQP expression and cytokine serum concentrations were measured. AQP3 mRNA expression increased over the duration of sepsis and was correlated with lymphocyte count. High AQP3 expression was associated with increased survival. In contrast, AQP9 expression was not altered during sepsis and was correlated with neutrophil count, and low levels of AQP9 were associated with increased survival. Furthermore, AQP9 expression was an independent risk factor for sepsis lethality. In conclusion, AQP3 and AQP9 may play contrary roles in the pathophysiology of sepsis, and these results suggest that AQP9 may be a novel drug target in sepsis and, concurrently, a valuable biomarker of the disease.

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“…Here, AQP3 could be involved in the regulatory volume decreases in NLRP3-mediated inflammation [30,31], and it could affect nigericin-induced interleukin-1β (IL-1β) release by facilitating cellular K + efflux [23]. In addition, as AQP3 also transports hydrogen peroxide, intracellular reactive oxygen species (ROS) rising with subsequent inflammasome activation could also be a possible mechanism [14,18].…”

Section: Discussionmentioning

confidence: 99%

“…AQP3 expression can be found in various parts of the intestine, regulates the proliferation and migration of intestinal epithelial cells, and is responsible for glycerol and hydrogen peroxide transport [13]. It is expressed and also has a direct function in immune cells [11,14,15]. The role of AQP3 described in immune systems is predominantly its function in T-cells [16,17].…”

Section: Introductionmentioning

confidence: 99%

The Aquaporin 3 Polymorphism (rs17553719) Is Associated with Sepsis Survival and Correlated with IL-33 Secretion

Ziehe,

Marko,

Thon

et al. 2024

IJMS

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Sepsis is a common life-threatening disease caused by dysregulated immune response and metabolic acidosis which lead to organ failure. An abnormal expression of aquaporins plays an important role in organ failure. Additionally, genetic variants in aquaporins impact on the outcome in sepsis. Thus, we investigated the polymorphism (rs17553719) and expression of aquaporin-3 (AQP3) and correlated these measurements with the survival of sepsis patients. Accordingly, we collected blood samples on several days (plus clinical data) from 265 sepsis patients who stayed in different ICUs in Germany. Serum plasma, DNA, and RNA were then separated to detect the promotor genotypes of AQP3 mRNA expression of AQP3 and several cytokines. The results showed that the homozygote CC genotype exhibited a significant decrease in 30-day survival (38.9%) compared to the CT (66.15%) and TT genotypes (76.3%) (p = 0.003). Moreover, AQP3 mRNA expression was significantly higher and nearly doubled in the CC compared to the CT (p = 0.0044) and TT genotypes (p = 0.018) on the day of study inclusion. This was accompanied by an increased IL-33 concentration in the CC genotype (day 0: p = 0.0026 and day 3: p = 0.008). In summary, the C allele of the AQP3 polymorphism (rs17553719) shows an association with increased AQP3 expression and IL-33 concentration accompanied by decreased survival in patients with sepsis.

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Aquaporins in Immune System

Cited by 5 publications

References 35 publications

Aquaporin-9 in the Brain Inflammatory Response: Evidence from Mice Injected with the Parkinsonogenic Toxin MPP+

Aquaporin-9 in the Brain Inflammatory Response: Evidence from Mice Injected with the Parkinsonogenic Toxin MPP+

AQP3 and AQP9—Contrary Players in Sepsis?

The Aquaporin 3 Polymorphism (rs17553719) Is Associated with Sepsis Survival and Correlated with IL-33 Secretion

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