Aquatic ecotoxicology of fluoxetine

Brooks, Bryan W.; Foran, Christy M.; Richards, Sean; Weston, James; Turner, Philip K.; Stanley, Jacob K.; Solomon, Keith R.; Slattery, Marc; Point, Thomas W. La

doi:10.1016/s0378-4274(03)00066-3

Cited by 391 publications

(232 citation statements)

References 51 publications

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“…Fluoxetine is one of the most widely used antidepressants in the world (Ankley et al., 2007; Brooks et al., 2003) and a large amount of research has documented its occurrence in aquatic (Bringolf et al., 2010; Corcoran et al., 2010; Kwon & Armbrust, 2006; Ramirez et al., 2009) and marine (Kreke & Dietrich, 2008; Vasskog et al., 2008) environments. With growing human populations in coastal zones, increasing use of antidepressants like fluoxetine is expected, suggesting higher future concentrations in the marine environment.…”

Section: Discussionmentioning

confidence: 99%

“…To address this data gap, we conducted a laboratory study to assess how predator presence and prolonged exposure to the pharmaceutical contaminant fluoxetine interact to shape risk behaviors among the shore crab, Hemigrapsus oregonensis . Fluoxetine has been frequently detected in coastal areas at low concentrations (0.03–300 ng/L; Kreke & Dietrich, 2008; Vasskog et al., 2008) and is considered toxic to fish and marine invertebrates at high concentrations (Brooks et al., 2003). We were interested in the role of fluoxetine as a persistent ecological stressor in estuaries where sublethal concentrations between 3 and 30 ng/L are commonly detected (Kreke & Dietrich, 2008; Vasskog et al., 2008).…”

Section: Introductionmentioning

confidence: 99%

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Prozac in the water: Chronic fluoxetine exposure and predation risk interact to shape behaviors in an estuarine crab

Peters

Granek

Rivera

et al. 2017

Ecology and Evolution

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Predators exert considerable top‐down pressure on ecosystems by directly consuming prey or indirectly influencing their foraging behaviors and habitat use. Prey is, therefore, forced to balance predation risk with resource reward. A growing list of anthropogenic stressors such as rising temperatures and ocean acidification has been shown to influence prey risk behaviors and subsequently alter important ecosystem processes. Yet, limited attention has been paid to the effects of chronic pharmaceutical exposure on risk behavior or as an ecological stressor, despite widespread detection and persistence of these contaminants in aquatic environments. In the laboratory, we simulated estuarine conditions of the shore crab, Hemigrapsus oregonensis, and investigated whether chronic exposure (60 days) to field‐detected concentrations (0, 3, and 30 ng/L) of the antidepressant fluoxetine affected diurnal and nocturnal risk behaviors in the presence of a predator, Cancer productus. We found that exposure to fluoxetine influenced both diurnal and nocturnal prey risk behaviors by increasing foraging and locomotor activity in the presence of predators, particularly during the day when these crabs normally stay hidden. Crabs exposed to fluoxetine were also more aggressive, with a higher frequency of agonistic interactions and increased mortality due to conflicts with conspecifics. These results suggest that exposure to field‐detected concentrations of fluoxetine may alter the trade‐off between resource acquisition and predation risk among crabs in estuaries. This fills an important data gap, highlighting how intra‐ and interspecific behaviors are altered by exposure to field concentrations of pharmaceuticals; such data more explicitly identify potential ecological impacts of emerging contaminants on aquatic ecosystems and can aid water quality management.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prozac in the water: Chronic fluoxetine exposure and predation risk interact to shape behaviors in an estuarine crab

Peters

Granek

Rivera

et al. 2017

Ecology and Evolution

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“…C. vulgaris was shown to be the least sensitive species for all SSRIs tested [183]. On the contrary, Pseudokirchneriella subcapitata was the most sensitive species mainly regarding fluoxetine with a reported EC50 of 24 µg L −1 after 48 h [177,184] or 45 µg L −1 when the exposure time was increased to 96 h [183]. Cell deformities in these green algae were noticed with just 13.6 µg L −1 of fluoxetine.…”

Section: Antidepressantsmentioning

confidence: 92%

“…They act by inhibit-ing the reuptake of serotonin from the pre-synaptic nerve cleft. It is thus obvious that from the presence of SSRIs in the envi-ronment (even at low concentrations (ng or µg L −1 )), adverse effects on aquatic organisms could arise [177]. In fact, fluvox-amine at a concentration of 0.32 µg L −1 or fluoxetine at higher concentrations were capable of inducing spawning and oocyte maturation of zebra mussels (Dreissena polymorpha) [178].…”

Section: Antidepressantsmentioning

confidence: 99%

Ecotoxicological aspects related to the presence of pharmaceuticals in the aquatic environment

Santos

Araújo

Fachini

et al. 2010

Journal of Hazardous Materials

1,302

533

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Pharmaceuticals are biologically active and persistent substances which have been recognized as a con-tinuing threat to environmental stability. Chronic ecotoxicity data as well as information on the current distribution levels in different environmental compartments continue to be sparse and are focused on those therapeutic classes that are more frequently prescribed and consumed. Nevertheless, they indicate the negative impact that these chemical contaminants may have on living organisms, ecosystems and ultimately, public health. This article reviews the different contamination sources as well as fate and both acute and chronic effects on nontarget organisms. An extensive review of existing data in the form of tables, encompassing many therapeutic classes is presented.Keywords: Pharmaceuticals, Sources, Environmental fate, Ecotoxicological effects

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“…The role of the serotonergic system in the control of fish maturation and reproduction is not definitively explained but the number of data showing its involvement in these processes is growing, also in the context of selective serotonin reuptake inhibitor (fluoxetine -an antidepressant drug) presence in the aquatic systems in significant concentrations (Kolpin et al 2002;Brooks et al 2003;Metcalfe et al 2010). This potential disruptor of serotonin-mediated physiological processes concentrates also in the tissues of wild-caught fish (Brooks et al 2005).…”

Section: Introductionmentioning

confidence: 99%

Serotonin, GnRH-A, and dopamine interaction in the control of in vivo luteinizing hormone release in Prussian carp (Carassius gibelio Bloch) at the time of gonad recrudescence

Sokolowska-Mikolajczyk¹,

Gajdzinski²,

Gosiewski³

et al. 2015

CZECH J ANIM SCI

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ABSTRACT:The effects of serotonin (5-HT), GnRH analogue (D-Ala 6 LHRH, GnRH-A) and dopamine antagonist -pimozide (PIM), on luteinizing hormone (LH) release in mature Prussian carp female (Carassius gibelio Bloch) were examined at the time of gonad recrudescence. Fish were intraperitoneally injected with 5-HT (10 mg/kg), GnRH-A (20 μg/kg) or PIM (5 mg/kg) or the combinations: 5-HT+GnRH-A, 5-HT+PIM, 5-HT+GnRH-A+PIM. Before the injection and 3, 6, 12 or 24 h after treatment blood samples were collected for LH levels determination by ELISA method. The analysis of LH concentrations, expressed as the percentage of pre-treatment, showed that serotonin alone had no influence on the spontaneous LH release, however the additive effects of serotonin and GnRH-A was observed. Serotonin potentiated the GnRH-A-stimulated LH release and potentiated also the effect of PIM. Extremely strong response to PIM and also to the combination with GnRH-A masked the participation of serotonin in the process of LH release in fish with recrudescing gonads. The interaction of serotonin GnRH-A and PIM in the control of LH release is discussed.

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Aquatic ecotoxicology of fluoxetine

Cited by 391 publications

References 51 publications

Prozac in the water: Chronic fluoxetine exposure and predation risk interact to shape behaviors in an estuarine crab

Prozac in the water: Chronic fluoxetine exposure and predation risk interact to shape behaviors in an estuarine crab

Ecotoxicological aspects related to the presence of pharmaceuticals in the aquatic environment

Serotonin, GnRH-A, and dopamine interaction in the control of in vivo luteinizing hormone release in Prussian carp (Carassius gibelio Bloch) at the time of gonad recrudescence

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