Aqueous Extract of Peanut Skin and Its Main Constituent Procyanidin A1 Suppress Serum IgE and IgG1 Levels in Mice-Immunized with Ovalbumin

Takano, Fumihide; Takata, Takanobu; Yoshihara, Akio; Nakamura, Yuka; Arima, Yukiko; Ohta, Tomihisa

doi:10.1248/bpb.30.922

Cited by 40 publications

(30 citation statements)

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“…25) And, they suppressed the expression of IgE receptors on human mast cells, and also reduced serum IgE levels in mice immunized with ovalbumin. 26,27) Especially, more recent study explained that condensed tannins induced Foxp3 and IL-10 expression in Jurkat T cells and increased Tr1 frequencies and numbers in vivo. 28) Therefore, RM-3 might reduce oxidative stress and pro-inflammatory signaling pathway in skin allergic inflammation, and activate Treg, leads to down-regulate Th2 cytokines-mediated immune system in this study.…”

Section: Effects On Clinical Skin Severitymentioning

confidence: 99%

Topical Application of <i>Rosa multiflora</i> Root Extract Improves Atopic Dermatitis-Like Skin Lesions Induced by Mite Antigen in NC/Nga Mice

Park

Jeong

Park

et al. 2014

Biological & Pharmaceutical Bulletin

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The roots of Rosa multiflora THUNB. (RM) has been used in oriental traditional medicines as remedies for scabies, rheumatic arthralgia and stomatitis which were practicably related with today's inflammatory and allergic diseases. In the present study, we evaluated whether RM root extract (RME) and its major constituent, 2-(3,4-dihydroxyphenyl)-6-(4-hydroxyphenyl)-8-(2,4-dihydroxyphenyl)-2,3-trans-6,7-cis-7,8-trans-3,4,7,8-tetrahydro-2H,6H-pyrano[2,3-f ] chromene-3,7,9-triol (RM-3) belongs to condensed tannins, improve atopic dermatitis (AD)-like skin lesions in NC/Nga mice induced by mite antigen. Topical application of RME as well as RM-3 improved skin severity and suppressed mRNA levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) on skin tissues, in addition, significantly reduced T helper 2 (Th2) immune responses via interleukin 10 (IL-10) up-regulation. Thus, RME, contains lots of condensed tannins such as RM-3 which possesses potent anti-inflammtory and immune-modulatory effects, may be useful for treatment of skin allergies and can be developed as new alternative herbal therapy against AD.Key words Rosa multiflora; Rosaceae; condensed tannin; proanthocyanidin; phlobatannin; atopic dermatitis Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by pruritic and eczematous skin lesion. This disease primarily occurs in infants and children, and the incidence is gradually increasing in developing as well as developed countries. Although the cause of AD has been still unclear, it has been understood as immune disorder characterized by increased immunoglobulin E (IgE) and T helper 2 (Th2) cytokine levels as well as presence of blood eosinophilia.1) Meanwhile, topical corticosteroids have been widely used as the main therapeutic strategy against AD, however they could only be used for short periods of time and in limited skin regions because of serious adverse effects such as aggravation and recurrence.2) Therefore, the demands of alternative therapies for AD have been increasing.Rosa multiflora THUNB. (RM), called as multiflora rose, baby rose, many-flowered rose and seven-sisters rose, is native to Eastern Asia. While RM has been used as rootstock for ornamental roses in Western, all parts of RM has been known as folk medicine in Eastern. Especially, hips have been widely used as diuretics and also registered on Korean and Japanese Pharmacopoeia. Meanwhile, root of RM have been rarely researched in recent year although it has been traditionally used for rheumatism, scabies and stomatitis.3) In our previous works, condensed tannins including novel stereoisomers (RM-1, 2 and 3) as well as catechin (CAT), and procyanidin B-3 (ProB3) were isolated from the roots of RM, and RM-1 and ProB3 showed to improve AD-like skin lesion in vivo. 4,5) As part of the research for development of herbal new drug, the present study was conducted to evaluate therapeutic effects of RM root extract (RME) as well as additional main compound, RM-3, belongs to phlobatannin which is a kind ...

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Section: Effects On Clinical Skin Severitymentioning

confidence: 99%

Topical Application of <i>Rosa multiflora</i> Root Extract Improves Atopic Dermatitis-Like Skin Lesions Induced by Mite Antigen in NC/Nga Mice

Park

Jeong

Park

et al. 2014

Biological & Pharmaceutical Bulletin

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“…Th-2 cytokines, including IL-4, IL-5 and IL-13, play important roles in allergic reactions, either triggering IgE production or attracting mast cells and eosinophils to inflammatory sites [27]. Polyphenol consumption attenuates allergenic re-exposure by inhibiting the adhesion and migration of peripheral B-cells, suppressing IgE and IgG1 levels and abrogating Th-2 cytokine production in sensitized mice [28][29][30]. In patients with asthma and other allergic diseases, functional deficits in Treg cells may be corrected by consumption of polyphenols as an alternative to other treatments such as corticosteroid use, allergen immunotherapy, vitamin D3 consumption, or prescription of long-acting β-agonists [26].…”

Section: Discussionmentioning

confidence: 99%

“…Cross-linking of two or more of these molecules triggers a sequence of reactions culminating in degranulation of the mast cells and, finally, release of inflammatory mediators into the nasal mucosa. Sneezing, itching and watery discharge follow [18,29]. Released IgE triggers increased production of leukotrienes and prostaglandins, which attract eosinophils, increase microvascular leakage, enhance edema, trigger mucous secretion, and augment kinin action [32].…”

Section: Discussionmentioning

confidence: 99%

Is resveratrol therapeutic when used to treat allergic rhinitis in rats?

Bozdemir¹,

Şahin²,

Altıntoprak³

et al. 2016

CIM

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TurkeyIs resveratrol therapeutic when used to treat allergic rhinitisinitis in rats?Abstract Purpose: Resveratrol has anti-infective, anti-inflammatory and antioxidant activities. The purpose of this study was to determine the effect of resveratrol in a rat experimental model of allergic rhinitis (AR).Methods: Wistar albino rats were divided into three groups: control (n=7), AR with no treatment (AR+NoTr, n=7) and AR with resveratrol treatment (AR+Res, n=7). For AR+Res, AR was induced and resveratrol given on days 21-28. On day 28, the total blood IgE levels were measured. Allergic symptoms (sneezing, nose-rubbing, eye lacrimation and nasal congestion) were scored on a 0-3 point scale, and histopathological changes in the nasal mucosa were evaluated.Results: Allergic symptom score of AR+NoTr was higher than the other two groups and the score of AR+Res was higher than the control group. Histopathologically, neither ciliary loss nor chondrocyte hypertrophy differed among the three groups; however, vascular congestion, inflammatory and plasma cell numbers, eosinophil and mast cell infiltration and goblet cell numbers were higher and mast cell infiltration was more prominent in AR+NoTr than in AR+Res and control. AR+Res and control did not differ significantly in any histological parameter.In AR+NoTr, nasal mucosa exhibited ciliary loss, squamous epithelial metaplasia, inflammatory cell infiltration, vascular congestion of the lamina propria and goblet cell epithelial metaplasia. In AR+Res, goblet cell metaplasia was focal or absent and infiltration of the lamina propria by inflammatory cells, eosinophils, and plasma cells was reduced relative to AR+NoTr.Conclusion: Allergic symptoms and tissue reactions were reduced by resveratrol treatment in rats with experimentally-induced AR.

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“…Electrospray ionization mass spectrometry (ESI-MS) analysis of the purified polyphenol gave m=z 599 ½M þ Na þ . Based on the results of 1 H-NMR, 13 C-NMR spectra, and optical rotation analysis, the polyphenol was identified as procyanidin A1. It inhibited the degranulation caused by antigen stimulation at the IC 50 of 20.3 M. Phorbol-12-myristate-13-acetate (PMA) and 2,5,-di(tert-butyl)-1,4-hydroquinone (DTBHQ)-induced processes of degranulation were also inhibited by procyanidin A1.…”

mentioning

confidence: 99%

“…11) Our group also found a hypocholesterolemic effect of PSE in rats fed a high-cholesterol diet. 12) Recent studies have indicated that oral injection of procyanidin A1 lowers serum IgE and IgG1 levels in mice, suggesting that it has an anti-allergic effect in vivo, 13) but no effect of peanut-skin procyanidins has been reported at the cellular level.…”

mentioning

confidence: 99%