Aqueous extract of the medicinal plant Patrinia villosa Juss. Induces angiogenesis via activation of focal adhesion kinase

Jeon, Jongwook; Lee, Jungsul; Kim, Chaehyun; An, Yun‐Kyu; Choi, Chulhee

doi:10.1016/j.mvr.2010.05.009

Cited by 32 publications

(13 citation statements)

References 31 publications

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“…FAK inhibitors, such as the one used in the present study, has been shown in early clinical trials to have anti-cancer effects in patients with lung cancer and breast cancer (36)(37)(38)(39)(40). Extract from herbs has been previously shown to affect the activities of FAK in endothelial cells (41,42). Together, it can be argued that one of the key pathways that Yangzheng Xiaoji targets is FAK pathway during the angiogenic process.…”

Section: Discussionmentioning

confidence: 65%

Inhibitory effects of Yangzheng Xiaoji on angiogenesis and the role of the focal adhesion kinase pathway

Jiang

et al. 2012

International Journal of Oncology

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Angiogenesis is an essential event during the excessive growth and metastatic spread of solid tumours. Anti-angiogenic agents have become a new choice of therapy for patients with cancer. In the present study, we investigated the potential effect of Yangzheng Xiaoji, a traditional Chinese medicinal formula presently used in the treatment of several solid tumours including liver cancer and gastric cancer, on angiogenesis, in vitro. The human vascular endothelial cell line HECV was used. A Matrigel-based sandwich tubule formation assay was employed to assess in vitro angiogenesis, a colorimetric method for assessing in vitro cell growth. Electric cell-substrate impedance sensing (ECIS) was used to evaluate the adhesion and migration of endothelial cells. The effects on activation of focal adhesion kinase (FAK) were evaluated using western blotting and immunofluorescence methods. Yangzhen Xiaoji extract DME25 significantly inhibited tube formation (p=0.046 vs control). This was seen together with a concentration-dependent inhibition on cell-matrix adhesion and cellular migration. It was demonstrated that the focal adhesion kinase (FAK) inhibitor PF557328 had a significant synergistic effect on DME25-induced inhibition of cell adhesion, migration and tube formation. The study showed that DME25 inhibited the phosphorylation of FAK in endothelial cells. In conclusion, Yangzhen Xiaoji has a marked effect on angiogenesis, in vitro and that this effect is at least partly mediated by the focal adhesion kinase (FAK) pathway.

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Section: Discussionmentioning

confidence: 65%

Inhibitory effects of Yangzheng Xiaoji on angiogenesis and the role of the focal adhesion kinase pathway

Jiang

et al. 2012

International Journal of Oncology

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“…Patrinia villosa Juss. ( P. villosa ), which is also known as Bai Hua Bai Jiang Cao in China, is a member of the family Valerianaceae (Jeon, Lee, Kim, An, & Choi, ). It is widely distributed in Asia and North America (Kim & Kang, ).…”

Section: Introductionmentioning

confidence: 99%

Iridoid glycoside and lignans from a wild vegetable (Patrinia villosa Juss.) with antioxidant activity

Bai

Liu

et al. 2018

J Food Biochem

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Patrinia villosa Juss. (P. villosa) is a beneficial wild vegetable, which is widely distributed in Asia and North America. It can be made into a salad, used as greens in porridge and soup for its fresh smells and highly nutritious. Chemical investigation of P. villosa led to the isolation, purification and identification of one new iridoid glycoside (1) along with nineteen known lignans (2-20). Their structures were established by comprehensive spectroscopic analyses. All compounds were evaluated for their antioxidant activities by ABTS, DPPH, and FRAP assays. Based on the results, P. villosa could be used as a new natural antioxidant in food industries and biomedical applications. Practical applicationsFresh fruits and vegetables are important sources of natural antioxidants, which can protect human from oxidative damage. Patrinia villosa Juss. (P. villosa) is a beneficial wild vegetable, and it is rich in many macroelements, microelements, and vitamins, which possess health-promoting properties. As a functional food, P. villosa has also been used to treat a number of diseases including chronic gastritis, mumps, tonsillitis, and gynecological conditions for hundreds years. In the article, one new iridoid glycoside along with nineteen known lignans were obtained from P. villosa and their antioxidant activities were evaluated by three different assays. The results can be expected to develop new natural antioxidant from P. villosa in food industries. K E Y W O R D S antioxidant activities, iridoid glycoside, lignan, Patrinia villosa

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“…Furthermore, it is reported that about 50% of the anticancer drugs are of natural origin (Harvey, 2008;Newman & Cragg, 2012), this fact has stimulated great interest in search for natural bioactive compounds present in medicinal plants (Demain & Vaishnav, 2011;Takemura, Sakakibara, Yamazaki, & Shimoi, 2013;You, An, Liang, & Wang, 2013). Patrinia villosa Juss belongs to the Valerianaceae family and is mainly distributed in East Asia and northeast North America (Jeon, Lee, Kim, An, & Choi, 2010). The tender leaves of Patrinia species have been used as a wild vegetable in China.…”

Section: Introductionmentioning

confidence: 99%

“…The whole plant of P. villosa in traditional oriental medicine has been used as an anti-inflammatory, anti-virus and anti-bacterial agent in China, Korea and Japan. (Jeon et al, 2010;Li, Zhao, Yu, & Dong, 2008;Taguchi, Yokokawa, & Endo, 1973;Xie, Peng, Fan, & Wu, 2008). Jeon et al (2010) reported that aqueous extract of the plant can induce angiogenesis.…”

Section: Introductionmentioning

confidence: 99%

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Antioxidant and antitumour activities of extracts from Patrinia villosa and its active constituents

Lei

Yang

Zhang

et al. 2015

Journal of Functional Foods

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Aqueous extract of the medicinal plant Patrinia villosa Juss. Induces angiogenesis via activation of focal adhesion kinase

Cited by 32 publications

References 31 publications

Inhibitory effects of Yangzheng Xiaoji on angiogenesis and the role of the focal adhesion kinase pathway

Inhibitory effects of Yangzheng Xiaoji on angiogenesis and the role of the focal adhesion kinase pathway

Iridoid glycoside and lignans from a wild vegetable (Patrinia villosa Juss.) with antioxidant activity

Antioxidant and antitumour activities of extracts from Patrinia villosa and its active constituents

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