Aqueous fraction from Costus spiralis (Jacq.) Roscoe leaf reduces contractility by impairing the calcium inward current in the mammalian myocardium

Abstract

The AqF of C. spiralis leaf depresses myocardial contractility by reducing the L-type calcium current and by decreasing the intracellular calcium transient. Despite the lack of data on the therapeutic dose of AqF used in folk medicine, our results support, at least in part, the traditional use of this plant to treat cardiac disorders.

In vivo assessment of cyto/genotoxic, antigenotoxic and antifungal potential of Costus spiralis (Jacq.) Roscoe leaves and stems

“…It was also demonstrated that the C. spiralis leaves aqueous fraction reduces mammalian myocardium contractility by impairing the calcium inward current in this muscle. This data support the use of C. spiralis in arterial hypertension or cardiac arrhythmias treatment (Britto et al 2011). The antioxidant activity of dichloromethane and methanol extracts of C. spiralis rhizome and root was also demonstrated.…”

“…It is known that the methanolic extract of C. spiralis leaves presents flavonoids, sterols and alkaloids (Braga et al 2007). The aqueous fraction instead presents phenols, tannins, flavones, xanthones, flavonoids, flavonols, flavononols, flavonones, and saponins (Britto et al 2011). Saponins and flavonol glycosides were isolated from C. spiralis rhizome and leaves, respectively (Antunes et al 2000, Silva andParente 2004).…”

Biological and Ecological Consequences ofDiolcogastersp. (Hymenoptera: Braconidae) ParasitizingAgaraea minuta(Lepidoptera: Arctiidae) and the Effects on TwoCostus(Costaceae) Plant Species in Brazil

“…Damage by A. minuta was sufficiently severe to reduce leaf yield, which is used in medical and pharmacological products (Da Silva & Parente 2004;Silva et al 2008;Quintans et al 2010;Britto et al 2011). Costus spp.…”

“…Costus spiralis has tortuous and branched stems, spirally arranged dark green leaves and red, odorless bracts and flowers (Viel et al 1999;Antunes et al 2000). This plant is used to manufacture pharmacological and herbal drugs and has been used in antidiabetic, antirheumatic, diuretic, sudorific and tonic drugs (Da Silva & Parente 2004;Britto et al 2011).…”

Ujı efektıvıtas ekstrak daun pacıng (Costus speciosus) terhadap penyembuhan luka sayat pada hewan uji kelinci (Oryctolagus cuniculus)

“…3 Menurut penelitian menujukkan bahwa daun pacing mengandung alkaloid, fenol, tanin, flavon, flavonoid, flavonol, dan saponin. 5 Berdasarkan penelitian di India, tumbuhan pacing (Costus spesiosus) dapat digunakan sebagai penyembuhan luka sayat baik bagian daun maupun rimpangnya. 6 Berdasarkan uraian diatas maka perlu dilakukan penelitian terkait aktivitas daun pacing (Costus speciosus) terhadap kesembuhan luka sayat pada kelinci (Oryctolagus cuniculus).…”