Aqueous humour and serum zinc and copper concentrations of patients with glaucoma and cataract.

Akyol, Nurettin; Keha, E. Edip; Kılıç, Saim

doi:10.1136/bjo.74.11.661

Cited by 35 publications

(33 citation statements)

References 6 publications

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“…Concentrations of copper, zinc and iron in the sera were determined by atomic absorption flame spectrophotometry as described elsewhere [45]. Pure copper, zinc and iron solutions (Sigma Chemicals Co, St. Louis, MO, USA) were used as reference standard material.…”

Section: Methodsmentioning

confidence: 99%

Serum antioxidant micromineral (Cu, Zn, Fe) status of drug dependent subjects: Influence of illicit drugs and lifestyle

Hossain

Kamal

Ahsan

et al. 2007

Subst Abuse Treat Prev Policy

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Background: Use of illicit drugs induces multiple nutrient deficiencies. Drug habit, sexual practice and socioeconomic factors influence the nutrient profile of drug dependent subjects. The literature on this issue is still insufficient. This study has tested the hypothesis that illicit drug use and lifestyle impair mineral status. To test this hypothesis, 253 men multiple drug users of age 18-45 years were recruited to investigate their serum copper, zinc and iron levels. Influence of illicit drugs and their lifestyle on the mineral levels was also examined. The study subjects were drug dependent who had shared needles and had sexual activity with multiple partners. Serum concentrations of the minerals were estimated by atomic absorption flame spectrometry.

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Section: Methodsmentioning

confidence: 99%

Serum antioxidant micromineral (Cu, Zn, Fe) status of drug dependent subjects: Influence of illicit drugs and lifestyle

Hossain

Kamal

Ahsan

et al. 2007

Subst Abuse Treat Prev Policy

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“…Zinc concentration in ocular tissues has been determined by flame or flameless atomic absorption spectrophotometry [37,[43][44][45][46][47][48][49][50][51][52], neutron activation [53,54], X-ray fluorescence [16], electron probe microanalysis [55], inductively coupled plasma-mass spectrometry [56,57] and plasma emission spectrophotometry [58]. The amount of zinc varies greatly with age and the ocular tissue examined; however, the retina and uvea usually contain the highest concentrations (Table 1) [16,37,52,53,56,57,59 -62].…”

Section: Localization and Concentration Of Zinc In The Eyementioning

confidence: 99%

Zinc and the Eye

Grahn

Paterson

Gottschall‐Pass

et al. 2001

Journal of the American College of Nutrition

152

118

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Zinc, a trace element that influences cell metabolism through a variety of mechanisms, appears to play an integral role in maintaining normal ocular function. This element is present in high concentrations in ocular tissue, particularly in retina and choroid. Zinc deficiency has been shown in a number of species to result in a variety of gross, ultrastructural and electrophysiologic ocular manifestations. The physiological functions for zinc have been studied predominantly in retina and retinal pigment epithelium where zinc is believed to interact with taurine and vitamin A. modify photoreceptor plasma membranes, regulate the light-rhodopsin reaction, modulate synaptic transmission and serve as an antioxidant. Suboptimal zinc status in North America may influence the development and progression of several chronic eye diseases. Zinc supplementation trials and epidemiological studies have produced conflicting results concerning the role of zinc in age-related macular degeneration. Additional well-controlled supplementation trials are indicated to clarify the role of zinc in this disease. Future investigations must also expand our understanding of the mechanisms by which zinc regulates ocular morphology and function.

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“…In this sparse body of work, there is indirect evidence of metal ion involvement in glaucoma; upregulation of metal-regulating genes and proteins have been shown in human glaucomatous retinas (Farkas et al 2004; Stasi et al 2007), and in monkey (Farkas et al 2004; Stasi et al 2007; Miyahara et al 2003) and mouse models of glaucoma (Stasi et al 2007; Miyahara et al 2003; Steele et al 2006). The roles of the metals themselves in glaucomatous neurodegeneration is unknown; however, Cu and Zn ions have been evaluated in terms of their relationship with intraocular pressure (IOP) modulation (Akyol et al 1990; Iqbal et al 2002), the major modifiable risk factor in glaucoma. This relationship, however, was not investigated in the context of the neural changes that cause vision loss.…”

mentioning

confidence: 99%

Abnormal metal levels in the primary visual pathway of the DBA/2J mouse model of glaucoma

et al. 2014

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The purpose of this study was to determine metal ion levels in central visual system structures of the DBA/2J mouse model of glaucoma. We used inductively coupled plasma mass spectrometry (ICP-MS) to measure levels of iron (Fe), copper (Cu), zinc (Zn), magnesium (Mg), manganese (Mn), and calcium (Ca) in the retina and retinal projection of 5-month (pre-glaucomatous) and 10-month (glaucomatous) old DBA/2J mice and age-matched C57BL/6J controls. We used microbeam X-ray fluorescence (μ-XRF) spectrometry to determine the spatial distribution of Fe, Zn, and Cu in the superior colliculus (SC), which is the major retinal target in rodents and one of the earliest sites of pathology in the DBA/2J mouse. Our ICP-MS experiments showed that glaucomatous DBA/2J had lower retinal Fe concentrations than pre-glaucomatous DBA/2J and age-matched C57BL/6J mice. Pre-glaucomatous DBA/2J retina had greater Mg, Ca, and Zn concentrations than glaucomatous DBA/2J and greater Mg and Ca than age-matched controls. Retinal Mn levels were significantly deficient in glaucomatous DBA/2J mice compared to aged-matched C57BL/6J and pre-glaucomatous DBA/2J mice. Regardless of age, the SC of C57BL/6J mice contained greater Fe, Mg, Mn, and Zn concentrations than the SC of DBA/2J mice. Greater Fe concentrations were measured by μ-XRF in both the superficial and deep SC of C57BL/6J mice than in DBA/2J mice. For the first time, we show direct measurement of metal concentrations in central visual system structures affected in glaucoma and present evidence for strain-related differences in metal content that may be specific to glaucomatous pathology.

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Aqueous humour and serum zinc and copper concentrations of patients with glaucoma and cataract.

Cited by 35 publications

References 6 publications

Serum antioxidant micromineral (Cu, Zn, Fe) status of drug dependent subjects: Influence of illicit drugs and lifestyle

Serum antioxidant micromineral (Cu, Zn, Fe) status of drug dependent subjects: Influence of illicit drugs and lifestyle

Zinc and the Eye

Abnormal metal levels in the primary visual pathway of the DBA/2J mouse model of glaucoma

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