Aqueous phase adsorption of certain beta-lactam antibiotics onto polymeric resins and activated carbon

Dutta, Madhulika; Dutta, Narendra Nath; Bhattacharya, K. G.

doi:10.1016/s1383-5866(99)00011-8

Cited by 88 publications

(40 citation statements)

References 19 publications

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“…It can be observed that adsorption intensity increased with increasing temperature. This behavior was also observed by other authors while studying several antibiotics [6,8]. Furthermore, the values of K are greater than unity, which indicates a strong interaction between the antibiotic and activated carbon [17].…”

Section: Adsorption Equilibrium Constants Of Amoxicillin On Activatedsupporting

confidence: 84%

“…The data obtained in this work may be useful for the design of continuous chromatographic processes under linear conditions. 6-APA [8] 3.92 7-ACA [6] 8.70…”

Section: Discussionmentioning

confidence: 99%

“…Adsorption is often used in downstream processing using various interactions, e.g., ionic, hydrophobic, affinity, etc., for the recovery of biomolecules, namely antibiotics [5]. Activated carbon and synthetic adsorbents have been used to remove biomolecules in the liquid phase [6][7][8], but no information is available on amoxicillin. Therefore, the purpose of this work is to study the separation of amoxicillin from reaction media as well as to evaluate the parameters of antibiotic adsorption onto activated carbon.…”

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confidence: 99%

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Activated Carbon Adsorbent for the Aqueous Phase Adsorption of Amoxicillin in a Fixed Bed

et al. 2010

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Equilibrium constant and mass transfer parameters are needed for the study of amoxicillin separation in any process involving adsorption in fixed beds. In this work, the adsorption of amoxicillin and 6-aminopenillanic acid in aqueous solution on activated carbon were studied using static adsorption tests. The adsorption capacity was found to be strongly dependent on the pH of the aqueous phase. The adsorption constants, overall mass transfer coefficients, and axial dispersion coefficients for amoxicillin and 6-aminopenillanic acid were determined, by moment analysis, from a series of step tests in a fixed bed packed with activated carbon. The total bed voidage and axial dispersion coefficient were estimated from blue dextran pulse test data at different flow rates. The results show that adsorption intensity increased with increasing temperature. Furthermore, the increasing trend of HETP with velocity suggests that axial dispersion and mass transfer resistance control the column efficiency. IntroductionAmoxicillin, with molecular dimensions of 15.622 Å × 18.785 Å × 6.645 Å [1], is one of the major b-lactam antibiotics due to its high spectrum of activity, high solubility, high rate of absorption, and its stability under acid conditions. In the industry, the majority of semisynthetic b-lactam antibiotics are prepared by chemical methods. These reactions typically involve costly steps such as subzero degree Celsius conditions (-30°C), and toxic organic solvents like methylene chloride and silylation reagents [2]. Therefore, the enzymatic synthesis of semisynthetic antibiotics is an interesting industrial process, since it reduces the number of reaction steps and decreases the amount and toxicity of waste products per kilogram of antibiotic [3]. However, in the enzymatic production of amoxicillin at 25°C and pH 6.5, when the maximum yield of antibiotic production is achieved, the reaction media is composed of the desired product (the antibiotic), undesired products (resultant from hydrolysis), and unreacted substrates. The recovery of these biomolecules from bioreactors may involve several methods of extraction and purification, playing an important role in the global economic productive analysis of the process [4]. Adsorption is often used in downstream processing using various interactions, e.g., ionic, hydrophobic, affinity, etc., for the recovery of biomolecules, namely antibiotics [5]. Activated carbon and synthetic adsorbents have been used to remove biomolecules in the liquid phase [6][7][8], but no information is available on amoxicillin. Therefore, the purpose of this work is to study the separation of amoxicillin from reaction media as well as to evaluate the parameters of antibiotic adsorption onto activated carbon. Experimental Chemicals and ReagentsAmoxicillin was kindly donated by Royton Ltda, Brazil. 6-aminopenicillanic acid (6-APA) and blue dextran were supplied by Winlab and Sigma-Aldrich, respectively. All other reagents were of analytical grade from different commercial brands. AdsorbentActivated ...

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Section: Adsorption Equilibrium Constants Of Amoxicillin On Activatedsupporting

confidence: 84%

“…The data obtained in this work may be useful for the design of continuous chromatographic processes under linear conditions. 6-APA [8] 3.92 7-ACA [6] 8.70…”

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Activated Carbon Adsorbent for the Aqueous Phase Adsorption of Amoxicillin in a Fixed Bed

et al. 2010

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“…However, some of the advanced technologies including temperature-phased anaerobic digestion and autothermal aerobic digestion processes have emerged (Wen et al 2009;Jin et al 2013). Further, the membrane filtration, ionised irradiation and oxidation processes by chemical disinfectants exhibited high treatment efficacy in the improvement of the quality of biosolids (Dutta et al 1999;Aksu and Tunc 2005;Gomez et al 2006;Dungeni et al 2010;Tripathi et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Removal of pathogenic bacteria from sewage-treated effluent and biosolids for agricultural purposes

et al. 2018

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The reuse of treated sewage for irrigation is considered as an important alternative water source in the new water management strategy of the countries that face a severe deficiency of water resources such as the Middle East countries. The organic material and fertilizing elements contained in biosolids are essential for maintaining soil fertility. However, both treated sewage and biosolids contain a large diversity of pathogens that would be transmitted to the environment and infect human directly or indirectly. Therefore, those pathogens should be reduced from the treated sewage and biosolids before the reuse in the agriculture. This paper reviews the considerations for reuse of treated sewage and biosolids in agriculture and further treatments used for reduction of pathogenic bacteria. The treatment methods used for the reduction of pathogens in these wastes have reviewed. It appeared that the main concern associated with the reduction of pathogenic bacteria lies in their ability to regrow in the treated sewage and biosolids. Therefore, the effective treatment method is that it has the potential to destruct pathogens cells and remove the nutrients to prevent the regrowth or recontamination from the surrounded environment. The removal of nutrients might be applicable in the sewage but not in the biosolids due to high nutrient contents. However, the reduction of health risk in the biosolids might be carried out by regulating the biosolid utilization and selecting the plant species grown in the fertilized soil with biosolids.

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“…Macroreticular polymeric resins have been widely used for adsorption and purification of bioactive compounds [10][11][12][13] from aqueous solution and can be easily regenerated using appropriate elution solvent. The first generation adsorbent, activated carbon (AC) has been widely used for removing organic compounds from aqueous solution [14][15][16]. We have been studying adsorptive separation processes for separation and purification of some useful biomolecules using polymeric resins and activated carbon [17,18].…”

Section: Introductionmentioning

confidence: 99%

Structural and thermodynamic factors on adsorptive interaction of certain flavonoids onto polymeric resins and activated carbon

Deka¹,

Saikia²

2015

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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Aqueous phase adsorption of certain beta-lactam antibiotics onto polymeric resins and activated carbon

Cited by 88 publications

References 19 publications

Activated Carbon Adsorbent for the Aqueous Phase Adsorption of Amoxicillin in a Fixed Bed

Activated Carbon Adsorbent for the Aqueous Phase Adsorption of Amoxicillin in a Fixed Bed

Removal of pathogenic bacteria from sewage-treated effluent and biosolids for agricultural purposes

Structural and thermodynamic factors on adsorptive interaction of certain flavonoids onto polymeric resins and activated carbon

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